Vgl-4 Activators

Vgl-4, also known as Vestigial-like protein 4, is a protein encoded by the VGLL4 gene in humans. It is part of the Vestigial-like protein family, which is known to be involved in transcriptional coactivation. Members of this family, including Vgl-4, are known to interact with transcription factors to modulate gene expression, playing essential roles in various cellular processes such as development, differentiation, and growth.

Vgl-4 has been particularly associated with the regulation of the Hippo signaling pathway, a crucial pathway involved in organ size control, cell proliferation, and apoptosis. Through its interaction with YAP, a major effector in the Hippo pathway, Vgl-4 can influence the transcriptional activity of various genes involved in these cellular processes. Additionally, Vgl-4 has been implicated in the suppression of cancer cell growth and invasion in various types of cancers, suggesting a potential tumor-suppressive role.