versican Activators
Versican, a proteoglycan with pivotal roles in cellular dynamics, undergoes intricate regulation by a diverse array of chemical activators. These compounds, each wielding a specific biochemical prowess, orchestrate a symphony of molecular events culminating in the activation of Versican. Retinoic acid, a derivative of vitamin A, indirectly influences Versican through the RAR/RXR signaling pathway, showcasing the intricacies of transcriptional control. Meanwhile, N-Acetylcysteine, a thiol compound, exerts its effects by enhancing cellular redox balance, thereby indirectly impacting Versican through the modulation of oxidative stress-responsive pathways. The indirect activation of Versican is further exemplified by Lithium Chloride, a regulator of the Wnt/β-catenin pathway. Lithium's inhibition of GSK-3β results in the stabilization of β-catenin, influencing Versican expression and contributing to cellular dynamics. This chemical dance extends to Y-27632, a selective ROCK inhibitor, affecting Versican through cytoskeletal organization alterations. These indirect activators exemplify the complexity of Versican regulation, as seen in the epigenetic modulation induced by 5-Azacytidine, a DNA methyltransferase inhibitor, altering gene promoters and influencing Versican expression. SB-431542 disrupts TGF-β signaling, revealing the crosstalk between TGF-β signaling and Versican regulation.
Histone deacetylase inhibitor Trichostatin A, PI3K inhibitor Wortmannin, and short-chain fatty acid Butyrate showcase the role of epigenetics and signaling pathways in Versican modulation. Piceatannol, a natural stilbene, and U0126, a MEK1/2 inhibitor, exemplify the impact of pathway-specific interventions, influencing Versican through JAK/STAT and MAPK/ERK signaling, respectively. Lastly, Nordihydroguaiaretic Acid (NDGA), a lipoxygenase inhibitor, introduces the modulation of arachidonic acid metabolism into the molecular repertoire, emphasizing the diverse strategies employed by Versican activators. In this intricate molecular ballet, each chemical fulfills a unique role, highlighting the versatility of Versican regulation in cellular contexts.
SEE ALSO...
Items 1 to 10 of 14 total
Display:
| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
PMA | 16561-29-8 | sc-3576 sc-3576A sc-3576B sc-3576C sc-3576D | 1 mg 5 mg 10 mg 25 mg 100 mg | $41.00 $132.00 $214.00 $500.00 $948.00 | 119 | |
PMA is a protein kinase C (PKC) activator that indirectly influences versican. It activates PKC, leading to downstream signaling events that modulate versican expression. The PKC-mediated pathway can involve transcriptional regulation, affecting versican levels and its role in extracellular matrix dynamics and cell-matrix interactions. | ||||||
Retinoic Acid, all trans | 302-79-4 | sc-200898 sc-200898A sc-200898B sc-200898C | 500 mg 5 g 10 g 100 g | $66.00 $325.00 $587.00 $1018.00 | 28 | |
Retinoic acid, a derivative of vitamin A, modulates the Versican protein indirectly through the RAR/RXR signaling pathway. Retinoic acid binds to retinoic acid receptors (RARs), affecting transcription and promoting the synthesis of factors influencing Versican expression. | ||||||
N-Acetyl-L-cysteine | 616-91-1 | sc-202232 sc-202232A sc-202232C sc-202232B | 5 g 25 g 1 kg 100 g | $34.00 $74.00 $270.00 $114.00 | 34 | |
N-Acetylcysteine, a thiol compound, indirectly activates Versican by enhancing cellular redox balance. Acting as a precursor for glutathione, NAC scavenges reactive oxygen species, mitigating oxidative stress. The resulting redox equilibrium positively impacts signaling cascades that influence Versican. | ||||||
Lithium | 7439-93-2 | sc-252954 | 50 g | $214.00 | ||
Lithium chloride indirectly activates Versican by modulating the Wnt/β-catenin pathway. Lithium inhibits GSK-3β, leading to β-catenin stabilization and nuclear translocation. This influences downstream transcriptional events, impacting Versican expression and contributing to cellular dynamics. | ||||||
Y-27632, free base | 146986-50-7 | sc-3536 sc-3536A | 5 mg 50 mg | $186.00 $707.00 | 88 | |
Y-27632, a selective Rho-associated protein kinase (ROCK) inhibitor, indirectly activates Versican by affecting cytoskeletal organization. Inhibition of ROCK alters actin dynamics, influencing signaling pathways that regulate Versican expression and contribute to cellular homeostasis. | ||||||
5-Azacytidine | 320-67-2 | sc-221003 | 500 mg | $280.00 | 4 | |
5-Azacytidine indirectly activates Versican through epigenetic modulation. As a DNA methyltransferase inhibitor, 5-Azacytidine demethylates gene promoters, including those related to Versican. This epigenetic alteration leads to increased transcription and expression of Versican in responsive cells. | ||||||
PGE2 | 363-24-6 | sc-201225 sc-201225C sc-201225A sc-201225B | 1 mg 5 mg 10 mg 50 mg | $57.00 $159.00 $275.00 $678.00 | 37 | |
PGE2 indirectly influences versican expression. It activates the EP receptor, leading to signaling events that impact versican transcription and synthesis. The PGE2-mediated pathway contributes to the regulation of versican levels, influencing extracellular matrix dynamics and cellular responses associated with versican, such as inflammation and tissue remodeling. | ||||||
SB 431542 | 301836-41-9 | sc-204265 sc-204265A sc-204265B | 1 mg 10 mg 25 mg | $82.00 $216.00 $416.00 | 48 | |
SB-431542, a selective inhibitor of TGF-β type I receptor ALK5, indirectly activates Versican by suppressing TGF-β signaling. Inhibition of ALK5 disrupts downstream events, affecting Versican expression. This highlights the crosstalk between TGF-β signaling and Versican regulation in cellular processes. | ||||||
Trichostatin A | 58880-19-6 | sc-3511 sc-3511A sc-3511B sc-3511C sc-3511D | 1 mg 5 mg 10 mg 25 mg 50 mg | $152.00 $479.00 $632.00 $1223.00 $2132.00 | 33 | |
Trichostatin A, a histone deacetylase inhibitor, indirectly activates Versican through chromatin modification. Inhibiting histone deacetylation alters the accessibility of gene promoters, influencing the transcription of Versican and contributing to its modulation in various cellular contexts. | ||||||
Wortmannin | 19545-26-7 | sc-3505 sc-3505A sc-3505B | 1 mg 5 mg 20 mg | $67.00 $223.00 $425.00 | 97 | |
Wortmannin indirectly activates Versican by targeting the PI3K/Akt pathway. Inhibition of PI3K by Wortmannin disrupts downstream signaling, impacting factors that regulate Versican expression. This molecular intervention reveals the intricate connections between PI3K/Akt signaling and Versican modulation. | ||||||