UR Activators
Urocortin 2 (UCN2), also known by several aliases such as UR, is a protein encoded by the UCN2 gene in humans, which belongs to the corticotropin-releasing factor (CRF) family. This peptide is an endogenous ligand for the CRF type 2 receptor (CRF2) and plays a pivotal role in the neuroendocrine system's response to stress. UCN2 is expressed in specific tissues, including the skin and endometrium, suggesting a localized role that might extend beyond stress to encompass other physiological functions. The gene's intricate regulation is indicative of its participation in various biological processes, hinting that alterations in its expression could have widespread effects. Understanding the factors that can induce UCN2 expression gives insights into the body's response mechanisms to environmental or internal stimuli.
Research into the molecular biology of UCN2 has revealed a multitude of compounds that could potentially serve as activators of its expression. Forskolin is known for its ability to increase intracellular cyclic AMP (cAMP) levels, which in turn can trigger a cascade of intracellular events culminating in the upregulation of UCN2. Similarly, the beta-adrenergic agonist isoproterenol can initiate a signaling pathway through its receptor to enhance the expression of UCN2, likely as a part of the physiological response to stress. Compounds like epinephrine and cortisol, which are integral to the stress response, might also stimulate UCN2 expression through their respective receptor-mediated pathways. On the other hand, substances such as sodium butyrate could induce UCN2 expression by modifying chromatin structure, thereby increasing gene accessibility and transcription. Vitamin D3, through its active metabolite, can engage vitamin D receptors to selectively foster transcription of specific genes, potentially including UCN2. It is through this intricate web of signaling pathways and gene regulatory networks that the expression of UCN2 can be finely tuned, reflecting the body's adaptive responses to a myriad of physiological challenges.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Forskolin | 66575-29-9 | sc-3562 sc-3562A sc-3562B sc-3562C sc-3562D | 5 mg 50 mg 1 g 2 g 5 g | $76.00 $150.00 $725.00 $1385.00 $2050.00 | 73 | |
Forskolin may elevate intracellular cAMP, which can initiate a signaling cascade culminating in the upregulation of UCN2 gene transcription. | ||||||
(−)-Epinephrine | 51-43-4 | sc-205674 sc-205674A sc-205674B sc-205674C sc-205674D | 1 g 5 g 10 g 100 g 1 kg | $40.00 $102.00 $197.00 $1739.00 $16325.00 | ||
Epinephrine, through interaction with beta-adrenergic receptors, may stimulate a signaling pathway that leads to increased transcription of the UCN2 gene. | ||||||
Hydrocortisone | 50-23-7 | sc-300810 | 5 g | $100.00 | 6 | |
Hydrocortisone can initiate a signaling pathway via glucocorticoid receptors that results in the upsurge of UCN2 mRNA synthesis as part of the body's stress response. | ||||||
Lithium | 7439-93-2 | sc-252954 | 50 g | $214.00 | ||
Lithium chloride can inhibit GSK-3, leading to the activation of transcription factors that stimulate the expression of stress-related genes including UCN2. | ||||||
Isoproterenol Hydrochloride | 51-30-9 | sc-202188 sc-202188A | 100 mg 500 mg | $27.00 $37.00 | 5 | |
As a beta-adrenergic agonist, isoproterenol can mimic adrenergic stress signals, triggering a cellular response that includes increased UCN2 expression. | ||||||
Sodium Butyrate | 156-54-7 | sc-202341 sc-202341B sc-202341A sc-202341C | 250 mg 5 g 25 g 500 g | $30.00 $46.00 $82.00 $218.00 | 18 | |
Sodium butyrate can lead to the acetylation of histones, thereby loosening chromatin structure and facilitating the access of transcription machinery to the UCN2 gene, enhancing its expression. | ||||||
Retinoic Acid, all trans | 302-79-4 | sc-200898 sc-200898A sc-200898B sc-200898C | 500 mg 5 g 10 g 100 g | $65.00 $319.00 $575.00 $998.00 | 28 | |
Retinoic acid can bind to its nuclear receptors and selectively stimulate the transcription of target genes, including potentially the UCN2 gene, by recruiting transcriptional co-activators. | ||||||
Dexamethasone | 50-02-2 | sc-29059 sc-29059B sc-29059A | 100 mg 1 g 5 g | $76.00 $82.00 $367.00 | 36 | |
Dexamethasone can bind glucocorticoid receptors and induce a transcriptional response that may include an upsurge in UCN2 gene expression within certain tissues. | ||||||
Insulin | 11061-68-0 | sc-29062 sc-29062A sc-29062B | 100 mg 1 g 10 g | $153.00 $1224.00 $12239.00 | 82 | |
Insulin can activate its receptor and corresponding signaling pathways, potentially culminating in the upregulation of UCN2 expression as part of metabolic homeostasis. | ||||||
Cholecalciferol | 67-97-0 | sc-205630 sc-205630A sc-205630B | 1 g 5 g 10 g | $70.00 $160.00 $290.00 | 2 | |
Cholecalciferol, through its hormonal form calcitriol, can bind to vitamin D receptors and selectively stimulate the transcription of genes, potentially including UCN2, in vitamin D-responsive cells. | ||||||