UNR Activators
NADK activators constitute a distinctive class of chemical compounds that possess the unique ability to enhance the activity or expression of NAD kinase (NADK), an enzyme intricately involved in the cellular regulation of nicotinamide adenine dinucleotide (NAD+). NAD+ stands as a pivotal coenzyme that exerts indispensable roles in diverse biological processes, including energy metabolism, DNA repair, and cellular signaling. The emergence of NADK activators has garnered substantial attention due to their potential to modulate NAD+ levels, thereby influencing downstream cellular functions. These activators can encompass a diverse array of chemical structures, yet they commonly share the property of augmenting NADK's activity through direct or indirect mechanisms. Some activators function by increasing the availability of NAD+ precursors, such as nicotinamide riboside (NR) or nicotinamide mononucleotide (NMN). These precursors serve as substrates for NAD+ synthesis, thereby facilitating the elevation of cellular NAD+ levels, which can lead to subsequent NADK activation. Additionally, NADK activators may target intracellular signaling pathways, such as those involving AMP-activated protein kinase (AMPK) or sirtuins, ultimately culminating in the modulation of NAD+ metabolism. These compounds often act as triggers, initiating a cascade of events that collectively contribute to the augmentation of NADK's enzymatic activity.
As our understanding of the intricate web of cellular processes continues to evolve, NADK activators hold significant promise as tools for investigating the fundamental roles of NAD+ in various physiological contexts. By enabling the manipulation of NADK activity, these compounds provide a means to explore the intricate interplay between NAD+ homeostasis and cellular functions, shedding light on the underlying mechanisms that govern vital biological processes. While not yet fully characterized in terms of their broader implications, NADK activators stand as promising entities that could potentially uncover novel insights into cellular regulatory networks and contribute to our comprehension of the intricate molecular choreography that sustains cellular life.
| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Actinomycin D | 50-76-0 | sc-200906 sc-200906A sc-200906B sc-200906C sc-200906D | 5 mg 25 mg 100 mg 1 g 10 g | $74.00 $243.00 $731.00 $2572.00 $21848.00 | 53 | |
Actinomycin D is an antibiotic that inhibits transcription by binding to DNA. By preventing RNA synthesis, it indirectly affects UNR. UNR's regulatory functions often rely on its interactions with specific RNA molecules. Actinomycin D can disrupt the transcription of these RNA targets, altering their availability for UNR binding and modulating its regulatory actions. | ||||||
Cordycepin | 73-03-0 | sc-203902 | 10 mg | $101.00 | 5 | |
Cordycepin is a nucleoside analog that can be incorporated into RNA during transcription. By interfering with RNA synthesis, cordycepin indirectly influences UNR. It can potentially affect the stability and processing of RNA molecules that UNR interacts with, thereby impacting its regulatory roles in post-transcriptional gene regulation. | ||||||
Rapamycin | 53123-88-9 | sc-3504 sc-3504A sc-3504B | 1 mg 5 mg 25 mg | $63.00 $158.00 $326.00 | 233 | |
Rapamycin is an immunosuppressant that inhibits the mTOR (mammalian target of rapamycin) pathway, a key regulator of translation. Indirectly, rapamycin can modulate UNR's activity by altering translation rates. UNR participates in translation regulation, and rapamycin's inhibition of mTOR can influence UNR's actions on mRNA translation. | ||||||
Cycloheximide | 66-81-9 | sc-3508B sc-3508 sc-3508A | 100 mg 1 g 5 g | $41.00 $84.00 $275.00 | 127 | |
Cycloheximide is a protein synthesis inhibitor that can impact translation rates. It indirectly affects UNR's function by altering the availability of nascent polypeptides and the pace of translation. UNR's role in translation regulation can be influenced by changes in protein synthesis dynamics. | ||||||
Leptomycin B | 87081-35-4 | sc-358688 sc-358688A sc-358688B | 50 µg 500 µg 2.5 mg | $107.00 $416.00 $1248.00 | 35 | |
Leptomycin B is a nuclear export inhibitor that can disrupt the export of RNA and proteins from the nucleus to the cytoplasm. By interfering with RNA localization processes, leptomycin B indirectly affects UNR. UNR participates in mRNA localization, and altering the cellular trafficking of RNA molecules can impact its regulatory functions. | ||||||