UGCG Activators
UGCG, or UDP-glucose ceramide glucosyltransferase, serves a pivotal role in the domain of sphingolipid metabolism. This enzyme facilitates the glycosylation step during the synthesis of glycosphingolipids, converting ceramide into glucosylceramide by transferring a glucose residue. Given the central importance of sphingolipids in various cellular processes ranging from cell signaling to apoptosis, the proper regulation and activity of UGCG are paramount. This brings forth a niche of compounds known as UGCG activators. These are molecules specifically designed or discovered to upregulate or enhance the enzymatic activity of UGCG.
UGCG activators, through their action, can have a profound effect on the sphingolipid balance within cells. By promoting the conversion of ceramide to glucosylceramide, these activators can potentially influence the levels of various downstream sphingolipids. The metabolic adjustments that arise due to the action of these activators might have implications for cellular signaling, lipid raft formation, and other processes linked to sphingolipids. Moreover, considering the intricate balance of lipids within cells, UGCG activators might indirectly affect other lipid classes and their associated metabolic pathways. These compounds, when understood deeply, can offer a detailed insight into the broad landscape of lipid metabolism and the sophisticated interplay of enzymes and substrates in maintaining cellular homeostasis.
Items 1 to 10 of 12 total
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
2,4-Thiazolidinedione | 2295-31-0 | sc-216281 | 50 g | $177.00 | 3 | |
Thiazolidinediones may affect sphingolipid metabolism, potentially leading to changes in UGCG expression to maintain lipid balance in cells. | ||||||
Retinoic Acid, all trans | 302-79-4 | sc-200898 sc-200898A sc-200898B sc-200898C | 500 mg 5 g 10 g 100 g | $65.00 $319.00 $575.00 $998.00 | 28 | |
Retinoic acid can modulate various lipid metabolic pathways, possibly influencing UGCG expression as a response to altered lipid profiles. | ||||||
Fumonisin B1 | 116355-83-0 | sc-201395 sc-201395A | 1 mg 5 mg | $117.00 $469.00 | 18 | |
This compound disrupts sphingolipid synthesis, which could upregulate UGCG as a compensatory mechanism. | ||||||
4-Hydroxyphenylretinamide | 65646-68-6 | sc-200900 sc-200900A | 5 mg 25 mg | $104.00 $315.00 | ||
4-Hydroxyphenylretinamide affects lipid metabolism, potentially impacting the expression of enzymes like UGCG. | ||||||
Staurosporine | 62996-74-1 | sc-3510 sc-3510A sc-3510B | 100 µg 1 mg 5 mg | $82.00 $150.00 $388.00 | 113 | |
Staurosporine can alter sphingolipid levels, possibly leading to increased UGCG expression to reestablish equilibrium. | ||||||
Dexamethasone | 50-02-2 | sc-29059 sc-29059B sc-29059A | 100 mg 1 g 5 g | $76.00 $82.00 $367.00 | 36 | |
As a glucocorticoid, dexamethasone might influence various metabolic pathways, including those involving UGCG. | ||||||
Myriocin (ISP-1) | 35891-70-4 | sc-201397 | 10 mg | $106.00 | 8 | |
By inhibiting serine palmitoyltransferase, myriocin impacts sphingolipid synthesis, potentially leading to changes in UGCG expression. | ||||||
Palmitic Acid | 57-10-3 | sc-203175 sc-203175A | 25 g 100 g | $112.00 $280.00 | 2 | |
As a fatty acid, palmitic acid may affect lipid metabolic pathways and subsequently influence UGCG expression. | ||||||
Oleic Acid | 112-80-1 | sc-200797C sc-200797 sc-200797A sc-200797B | 1 g 10 g 100 g 250 g | $36.00 $102.00 $569.00 $1173.00 | 10 | |
Oleic acid's impact on lipid metabolism might result in changes to the expression of UGCG. | ||||||
5-Azacytidine | 320-67-2 | sc-221003 | 500 mg | $280.00 | 4 | |
This compound might affect the methylation status of genes, potentially leading to the induction of UGCG expression. | ||||||