UBL5 Activators
UBL5 Activators are a class of compounds that influence the functional activity of UBL5, a ubiquitin-like modifier that plays a role in post-translational modifications. These activators are characterized by their ability to either stabilize proteins within the same pathways as UBL5 or affect the ubiquitin-proteasome system in a manner that increases the availability of UBL5's substrates. The compounds achieve this by inhibiting proteasomal degradation, autophagy, or specific enzymes involved in ubiquitination and deubiquitination processes, thereby enhancing the functional role of UBL5 in the cell. The primary mechanism through which these activators operate is by modulating the stability and processing of proteins that interact with or are modified by UBL5, rather than by directly binding to or modifying UBL5 itself.
The actions of UBL5 Activators are not limited to the direct inhibition or activation of enzymes but extend to the alteration of broader cellular processes that govern protein turnover and modification. By inhibiting proteasomal activity or autophagy, these compounds indirectly lead to an increase in the pool of ubiquitinated proteins, which could enhance the need for UBL5's role in processing these proteins. Inhibition of specific deubiquitinating enzymes further shifts the equilibrium towards a state of increased ubiquitin-like modification, a process in which UBL5 is intimately involved. These activators thus serve to indirectly increase UBL5's functional activity by creating a cellular context that requires its ubiquitin-like modification activity, underscoring the importance of protein stability and turnover in the regulation of UBL5 function.
| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
MG-132 [Z-Leu- Leu-Leu-CHO] | 133407-82-6 | sc-201270 sc-201270A sc-201270B | 5 mg 25 mg 100 mg | $60.00 $265.00 $1000.00 | 163 | |
A proteasome inhibitor that prevents the degradation of ubiquitinated proteins, thereby potentially increasing the availability of UBL5 for its functional role in ubiquitin-like post-translational modifications. | ||||||
Chloroquine | 54-05-7 | sc-507304 | 250 mg | $69.00 | 2 | |
An autophagy inhibitor that may lead to the accumulation of ubiquitinated proteins, indirectly enhancing the functional activity of UBL5 by increasing its substrate pool. | ||||||
MLN 4924 | 905579-51-3 | sc-484814 | 1 mg | $286.00 | 1 | |
A NEDD8-activating enzyme inhibitor which can indirectly affect ubiquitin-like protein conjugation pathways, possibly leading to enhanced UBL5 activity in protein modification processes. | ||||||
Ubiquitin E1 Inhibitor, PYR-41 | 418805-02-4 | sc-358737 | 25 mg | $360.00 | 4 | |
A ubiquitin-activating enzyme E1 inhibitor, which could lead to altered ubiquitination dynamics, indirectly enhancing the functional role of UBL5 in ubiquitin-like processing. | ||||||
Bortezomib | 179324-69-7 | sc-217785 sc-217785A | 2.5 mg 25 mg | $135.00 $1085.00 | 115 | |
A proteasome inhibitor that could indirectly increase the functional activity of UBL5 by stabilizing proteins that are involved in the same pathways as UBL5. | ||||||
Thalidomide | 50-35-1 | sc-201445 sc-201445A | 100 mg 500 mg | $111.00 $357.00 | 8 | |
A molecule that promotes the degradation of specific transcription factors. Its action could lead to an altered cellular environment enhancing the activity of UBL5 due to changes in the ubiquitin-proteasome system. | ||||||
Leupeptin hemisulfate | 103476-89-7 | sc-295358 sc-295358A sc-295358D sc-295358E sc-295358B sc-295358C | 5 mg 25 mg 50 mg 100 mg 500 mg 10 mg | $73.00 $148.00 $316.00 $499.00 $1427.00 $101.00 | 19 | |
A protease inhibitor which may lead to the accumulation of proteins that interact with UBL5, potentially enhancing its functional role in protein modification. | ||||||
Epoxomicin | 134381-21-8 | sc-201298C sc-201298 sc-201298A sc-201298B | 50 µg 100 µg 250 µg 500 µg | $137.00 $219.00 $449.00 $506.00 | 19 | |
A selective proteasome inhibitor that may enhance the functional activity of UBL5 by increasing the levels of proteins that require post-translational modifications. | ||||||
P22077 | 1247819-59-5 | sc-478536 | 10 mg | $165.00 | ||
An inhibitor of ubiquitin-specific protease 7 (USP7), which could lead to altered deubiquitination dynamics, potentially enhancing the role of UBL5 in ubiquitin-like protein conjugation. | ||||||
IU1 | 314245-33-5 | sc-361215 sc-361215A sc-361215B | 10 mg 50 mg 100 mg | $138.00 $607.00 $866.00 | 2 | |
An inhibitor of the deubiquitinating enzyme USP14, which may result in an increased pool of ubiquitinated proteins, indirectly enhancing the functional activity of UBL5. | ||||||