TZFP Inhibitors
TZFP inhibitors represent a specialized class of chemical compounds that target the function of proteins containing the TZFP motif, or tandem zinc finger proteins. Tandem zinc finger proteins are characterized by the presence of multiple zinc finger domains, which are small, stable protein structural motifs that coordinate zinc ions and facilitate DNA binding, protein-protein interactions, or RNA binding. These proteins are often involved in transcriptional regulation, as zinc finger motifs allow for precise recognition and interaction with specific DNA sequences. Inhibition of TZFPs can disrupt their ability to bind DNA or interact with other molecules, potentially altering gene expression pathways that rely on these proteins for transcriptional control. This makes TZFP inhibitors key molecules of interest in understanding gene regulatory networks and transcriptional repression mechanisms.
Structurally, TZFP inhibitors often feature molecular components that interact with the zinc finger domains, either by binding directly to the zinc ion coordination site or by altering the conformation of the protein, thereby preventing its functional activity. These inhibitors may employ various strategies to impede the function of TZFPs, including blocking the protein-DNA interaction or disrupting protein complex formations. The study of TZFP inhibitors also contributes to the broader understanding of zinc finger protein behavior and the intricate role of these proteins in regulating various cellular processes, such as chromatin remodeling, DNA repair, and epigenetic modifications. Research into TZFP inhibitors expands our knowledge of molecular interactions that govern essential biological functions and sheds light on how zinc finger motifs contribute to the fine-tuning of genetic regulation.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
5-Azacytidine | 320-67-2 | sc-221003 | 500 mg | $280.00 | 4 | |
By inhibiting DNA methyltransferases, 5-Azacytidine could lead to the demethylation and subsequent downregulation of the TZFP gene promoter, thereby decreasing TZFP protein synthesis. | ||||||
Trichostatin A | 58880-19-6 | sc-3511 sc-3511A sc-3511B sc-3511C sc-3511D | 1 mg 5 mg 10 mg 25 mg 50 mg | $149.00 $470.00 $620.00 $1199.00 $2090.00 | 33 | |
Trichostatin A could specifically reduce TZFP expression by maintaining histones in a hyperacetylated state, leading to an open chromatin configuration that disfavors the transcription of the TZFP gene. | ||||||
Valproic Acid | 99-66-1 | sc-213144 | 10 g | $85.00 | 9 | |
Valproic acid may downregulate TZFP by inhibiting histone deacetylase activity, resulting in an accumulation of acetylated histones and a decrease in the transcriptional repression of the TZFP gene. | ||||||
Sodium Butyrate | 156-54-7 | sc-202341 sc-202341B sc-202341A sc-202341C | 250 mg 5 g 25 g 500 g | $30.00 $46.00 $82.00 $218.00 | 19 | |
As an HDAC inhibitor, sodium butyrate could theoretically decrease TZFP expression by causing hyperacetylation of histones associated with the TZFP gene, disrupting its normal transcription. | ||||||
Mithramycin A | 18378-89-7 | sc-200909 | 1 mg | $54.00 | 6 | |
Mithramycin A might bind to GC-rich sequences in the promoter region of the TZFP gene, preventing transcription factors from initiating TZFP transcription, hence reducing its protein levels. | ||||||
Disulfiram | 97-77-8 | sc-205654 sc-205654A | 50 g 100 g | $52.00 $87.00 | 7 | |
By modifying the intracellular environment, disulfiram could indirectly downregulate TZFP expression by altering signaling pathways that control the transcription of the TZFP gene. | ||||||
Retinoic Acid, all trans | 302-79-4 | sc-200898 sc-200898A sc-200898B sc-200898C | 500 mg 5 g 10 g 100 g | $65.00 $319.00 $575.00 $998.00 | 28 | |
Retinoic acid might downregulate TZFP expression by binding to its nuclear receptors, which may alter the transcription of target genes, including potentially repressing the TZFP gene. | ||||||
Methotrexate | 59-05-2 | sc-3507 sc-3507A | 100 mg 500 mg | $92.00 $209.00 | 33 | |
Methotrexate could theoretically inhibit TZFP expression by disrupting folate metabolism, leading to an imbalance in nucleotide pools and subsequent suppression of TZFP gene transcription. | ||||||
Hydroxyurea | 127-07-1 | sc-29061 sc-29061A | 5 g 25 g | $76.00 $255.00 | 18 | |
Hydroxyurea could lead to a reduction in TZFP levels by inhibiting ribonucleotide reductase, impairing DNA synthesis, and thus downregulating DNA-dependent gene expression including TZFP. | ||||||
Chloroquine | 54-05-7 | sc-507304 | 250 mg | $68.00 | 2 | |
Chloroquine may decrease TZFP expression by interfering with the replication and transcription machinery of the cell, leading to a global downregulation of gene expression including that of TZFP. | ||||||