TSPY Inhibitors
TSPY inhibitors are a diverse set of compounds that, while not directly targeting TSPY1, function to modulate cellular pathways and processes where TSPY1 exerts its influence, especially in cell proliferation and tumorigenesis. PD0332991, a CDK4/6 inhibitor, serves as a poignant example, impacting the cell cycle and hence potentially influencing the proliferative effects associated with TSPY1. Similarly, Nutlin-3, which inhibits the interaction between MDM2 and p53, can amplify the tumor suppressor function of p53, thereby potentially counteracting TSPY1's pro-tumorigenic role.
Furthermore, the realm of epigenetic modulation provides compounds like 5-Azacytidine and Trichostatin A, which act as DNA methyltransferase and HDAC inhibitors respectively. By altering gene expression profiles and chromatin structures, these compounds introduce avenues through which TSPY1 expression or function might be indirectly modified. Gefitinib, a well-known EGFR tyrosine kinase inhibitor, and the PI3K inhibitors, LY294002 and Wortmannin, contribute to this class by targeting proliferative signaling pathways, which TSPY1 is believed to have a role in.
Items 1 to 10 of 11 total
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
PD 0332991 Isethionate | 827022-33-3 | sc-478943 | 1 mg | $300.00 | ||
CDK4/6 inhibitor that impacts cell cycle progression. By inhibiting these kinases, it can influence TSPY1-related cell proliferation. | ||||||
Nutlin-3 | 548472-68-0 | sc-45061 sc-45061A sc-45061B | 1 mg 5 mg 25 mg | $62.00 $225.00 $779.00 | 24 | |
MDM2-p53 interaction inhibitor. Enhancing p53 activity can suppress the proliferative effect associated with TSPY1. | ||||||
5-Azacytidine | 320-67-2 | sc-221003 | 500 mg | $280.00 | 4 | |
DNA methyltransferase inhibitor. It reactivates silenced genes, possibly affecting TSPY1 expression indirectly. | ||||||
Trichostatin A | 58880-19-6 | sc-3511 sc-3511A sc-3511B sc-3511C sc-3511D | 1 mg 5 mg 10 mg 25 mg 50 mg | $152.00 $479.00 $632.00 $1223.00 $2132.00 | 33 | |
HDAC inhibitor. It modifies chromatin structure, potentially influencing TSPY1 transcription. | ||||||
Gefitinib | 184475-35-2 | sc-202166 sc-202166A sc-202166B sc-202166C | 100 mg 250 mg 1 g 5 g | $63.00 $114.00 $218.00 $349.00 | 74 | |
EGFR tyrosine kinase inhibitor. TSPY1 may be influenced when EGFR signaling, associated with proliferation, is inhibited. | ||||||
17-AAG | 75747-14-7 | sc-200641 sc-200641A | 1 mg 5 mg | $67.00 $156.00 | 16 | |
HSP90 inhibitor. Affects numerous cellular pathways including those that TSPY1 may be involved in. | ||||||
Y-27632, free base | 146986-50-7 | sc-3536 sc-3536A | 5 mg 50 mg | $186.00 $707.00 | 88 | |
ROCK inhibitor. By inhibiting Rho-associated protein kinases, it may indirectly modulate processes influenced by TSPY1. | ||||||
LY 294002 | 154447-36-6 | sc-201426 sc-201426A | 5 mg 25 mg | $123.00 $400.00 | 148 | |
PI3K inhibitor. By blocking the PI3K-AKT pathway, it may indirectly influence TSPY1's role in proliferation. | ||||||
D,L-Sulforaphane | 4478-93-7 | sc-207495A sc-207495B sc-207495C sc-207495 sc-207495E sc-207495D | 5 mg 10 mg 25 mg 1 g 10 g 250 mg | $153.00 $292.00 $489.00 $1325.00 $8465.00 $933.00 | 22 | |
Nrf2 pathway activator. This can lead to an antioxidant response which might counteract TSPY1's tumorigenic role. | ||||||
Wortmannin | 19545-26-7 | sc-3505 sc-3505A sc-3505B | 1 mg 5 mg 20 mg | $67.00 $223.00 $425.00 | 97 | |
Another PI3K inhibitor. Its effect on the PI3K-AKT pathway might impact TSPY1's role in cell proliferation. | ||||||