TRPD52L3 Inhibitors
TRPD52L3 inhibitors are a class of chemical compounds specifically designed to target and inhibit the activity of TRPD52L3, a member of the tumor protein D52-like (TPD52L) family of proteins. TRPD52L3 is involved in various cellular processes, including vesicle trafficking, secretion, and the regulation of intracellular signaling pathways. This protein plays a role in regulating the transport of vesicles within cells and is also implicated in cell growth and proliferation. Inhibitors of TRPD52L3 are designed to block its function by interfering with its ability to bind to other proteins or lipids that are necessary for vesicle movement and intracellular communication. By inhibiting TRPD52L3, these compounds can alter vesicular dynamics and disrupt cellular processes that rely on proper intracellular transport.
The chemical design of TRPD52L3 inhibitors typically focuses on specific regions of the protein that are critical for its interaction with other molecules, such as protein-binding domains or lipid-interaction motifs. These inhibitors may work by competitively binding to these domains, preventing TRPD52L3 from associating with its natural binding partners, or by stabilizing the protein in an inactive conformation. High specificity is key to developing effective TRPD52L3 inhibitors, as other proteins in the TPD52L family share structural similarities. Researchers study these inhibitors to better understand the precise role of TRPD52L3 in vesicle trafficking and how it regulates intracellular transport systems. Investigating TRPD52L3 inhibitors also provides insight into broader mechanisms of protein-protein interactions, vesicular transport, and the regulation of intracellular signaling pathways across different cell types and tissues.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Etoposide (VP-16) | 33419-42-0 | sc-3512B sc-3512 sc-3512A | 10 mg 100 mg 500 mg | $32.00 $170.00 $385.00 | 63 | |
Etoposide may inhibit TPD52L3 expression by interfering with topoisomerase II activity, leading to DNA damage and subsequently triggering cell cycle arrest and apoptosis. This disturbance in cellular processes may downregulate the expression of TPD52L3. | ||||||
Trichostatin A | 58880-19-6 | sc-3511 sc-3511A sc-3511B sc-3511C sc-3511D | 1 mg 5 mg 10 mg 25 mg 50 mg | $149.00 $470.00 $620.00 $1199.00 $2090.00 | 33 | |
Trichostatin A may inhibit TPD52L3 expression by acting as a potent histone deacetylase (HDAC) inhibitor, leading to global histone hyperacetylation, alterations in chromatin structure, and ultimately affecting the transcriptional regulation of TPD52L3. | ||||||
Camptothecin | 7689-03-4 | sc-200871 sc-200871A sc-200871B | 50 mg 250 mg 100 mg | $57.00 $182.00 $92.00 | 21 | |
Camptothecin may inhibit TPD52L3 expression by inhibiting topoisomerase I, leading to DNA damage and cell cycle arrest. This disruption in cellular processes may lead to the downregulation of TPD52L3 expression. | ||||||
Suberoylanilide Hydroxamic Acid | 149647-78-9 | sc-220139 sc-220139A | 100 mg 500 mg | $130.00 $270.00 | 37 | |
Vorinostat may inhibit TPD52L3 expression by acting as an HDAC inhibitor, leading to the hyperacetylation of histones, resulting in altered chromatin structure and transcriptional regulation that may ultimately downregulate the expression of TPD52L3. | ||||||
Actinomycin D | 50-76-0 | sc-200906 sc-200906A sc-200906B sc-200906C sc-200906D | 5 mg 25 mg 100 mg 1 g 10 g | $73.00 $238.00 $717.00 $2522.00 $21420.00 | 53 | |
Actinomycin D may inhibit TPD52L3 expression by intercalating into DNA, thereby preventing transcription and RNA synthesis. This inhibition of transcriptional processes may lead to the downregulation of TPD52L3 expression. | ||||||
Cisplatin | 15663-27-1 | sc-200896 sc-200896A | 100 mg 500 mg | $76.00 $216.00 | 101 | |
Cisplatin may inhibit TPD52L3 expression by inducing DNA damage and triggering apoptosis through the formation of DNA adducts. The resulting cellular response may involve downregulation of TPD52L3 expression. | ||||||
Taxol | 33069-62-4 | sc-201439D sc-201439 sc-201439A sc-201439E sc-201439B sc-201439C | 1 mg 5 mg 25 mg 100 mg 250 mg 1 g | $40.00 $73.00 $217.00 $242.00 $724.00 $1196.00 | 39 | |
Paclitaxel may inhibit TPD52L3 expression by stabilizing microtubules and interfering with their dynamics, leading to cell cycle arrest and apoptosis. This disruption in cellular processes may result in the downregulation of TPD52L3 expression. | ||||||
Fluorouracil | 51-21-8 | sc-29060 sc-29060A | 1 g 5 g | $36.00 $149.00 | 11 | |
5-Fluorouracil may inhibit TPD52L3 expression by interfering with nucleic acid synthesis, leading to the disruption of DNA replication and ultimately triggering cell cycle arrest and apoptosis. These effects may lead to the downregulation of TPD52L3 expression. | ||||||
2′-Deoxy-2′,2′-difluorocytidine | 95058-81-4 | sc-275523 sc-275523A | 1 g 5 g | $56.00 $128.00 | ||
Gemcitabine may inhibit TPD52L3 expression by interfering with DNA synthesis and inducing the termination of DNA elongation, leading to cell cycle arrest and apoptosis. These disruptions may contribute to the downregulation of TPD52L3 expression. | ||||||
Methotrexate | 59-05-2 | sc-3507 sc-3507A | 100 mg 500 mg | $92.00 $209.00 | 33 | |
Methotrexate may inhibit TPD52L3 expression by interfering with dihydrofolate reductase, leading to the disruption of nucleotide synthesis and ultimately triggering cell cycle arrest and apoptosis. These effects may contribute to the downregulation of TPD52L3 expression. | ||||||