Date published: 2025-9-12

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TRIM5α Inhibitors

TRIM5α inhibitors represent a class of compounds aimed at modulating the activity of the TRIM5α protein, a member of the tripartite motif (TRIM) family. TRIM5α, a cytoplasmic protein, plays a crucial role in the recognition and restriction of viral infections through its interaction with viral capsid structures. The protein features several distinctive structural domains, including an N-terminal RING domain, a B-box domain, and a coiled-coil region, which together form a scaffold for specific protein-protein interactions. The C-terminal portion of TRIM5α contains a SPRY (or B30.2) domain, which is essential for recognizing viral capsids. TRIM5α inhibitors target these functional domains, particularly the SPRY domain, thereby interfering with the protein's ability to bind to capsids. This interruption prevents the proper oligomerization and subsequent formation of restriction complexes, leading to a loss of its normal viral recognition and degradation functions.

The development of TRIM5α inhibitors often focuses on their ability to modulate the protein's structural dynamics. These inhibitors can act by stabilizing or destabilizing TRIM5α in its inactive or active forms, thereby altering the overall architecture of the protein in relation to its substrates. The precise modulation of TRIM5α through inhibition is a delicate process because of the protein's significant roles in immune signaling and cellular responses. Researchers in this area often study the binding affinities, interaction kinetics, and allosteric effects of these inhibitors to understand how they can induce conformational changes in TRIM5α without disrupting its broader cellular functions. The chemical design of TRIM5α inhibitors requires careful consideration of both the active site characteristics and the protein's quaternary structure to ensure selective binding and minimal off-target effects in molecular assays.

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Product NameCAS #Catalog #QUANTITYPriceCitationsRATING

5-Aza-2′-Deoxycytidine

2353-33-5sc-202424
sc-202424A
sc-202424B
25 mg
100 mg
250 mg
$214.00
$316.00
$418.00
7
(1)

5-Aza-2′-Deoxycytidine could lead to reduced methylation levels of the TRIM5α gene, thereby inhibiting its expression through DNA methyltransferase inhibition.

Suberoylanilide Hydroxamic Acid

149647-78-9sc-220139
sc-220139A
100 mg
500 mg
$130.00
$270.00
37
(2)

Suberoylanilide Hydroxamic Acid may lead to the hyperacetylation of histones associated with the TRIM5α gene, potentially leading to transcriptional downregulation of the gene.