TPPP2 Inhibitors
TPPP2 inhibitors encompass a variety of chemical compounds that exert their inhibitory effects through direct interactions with tubulin, the protein building block of microtubules, which TPPP2 is known to promote the polymerization of. These inhibitors often bind to tubulin, preventing its polymerization into microtubules, thereby directly countering the function of TPPP2. Some inhibitors work by stabilizing microtubules in such a way that precludes the need for TPPP2 activity, whereas others bind to tubulin monomers, blocking their assembly into microtubules. This effectively neutralizes TPPP2's role in the polymerization process. There are also inhibitors that disrupt microtubule dynamics by depolymerizing microtubules, which is antithetical to the polymerizing action of TPPP2.
The inhibition of TPPP2 by these chemicals can be highly specific, targeting the microtubule assembly process that is fundamental to the protein's function. Some compounds achieve this by binding to specific sites on tubulin, thus preventing the elongation of microtubules, which TPPP2 would otherwise facilitate. Others influence the microtubule dynamics, either by preventing the growth phase of microtubule formation or by causing existing microtubules to disassemble, which again runs counter to TPPP2's polymerization-promoting activity.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Taxol | 33069-62-4 | sc-201439D sc-201439 sc-201439A sc-201439E sc-201439B sc-201439C | 1 mg 5 mg 25 mg 100 mg 250 mg 1 g | $41.00 $74.00 $221.00 $247.00 $738.00 $1220.00 | 39 | |
This compound stabilizes microtubules and prevents their disassembly, which can inhibit the function of TPPP2, known for its role in tubulin polymerization. | ||||||
Colchicine | 64-86-8 | sc-203005 sc-203005A sc-203005B sc-203005C sc-203005D sc-203005E | 1 g 5 g 50 g 100 g 500 g 1 kg | $100.00 $321.00 $2289.00 $4484.00 $18207.00 $34749.00 | 3 | |
By binding to tubulin, this alkaloid disrupts microtubule polymerization. TPPP2's ability to promote tubulin polymerization is therefore hindered by colchicine's action. | ||||||
Vinblastine | 865-21-4 | sc-491749 sc-491749A sc-491749B sc-491749C sc-491749D | 10 mg 50 mg 100 mg 500 mg 1 g | $102.00 $235.00 $459.00 $1749.00 $2958.00 | 4 | |
As an anti-mitotic alkaloid, it interferes with microtubule assembly. This action competes with TPPP2's tubulin polymerization-promoting activity. | ||||||
Podophyllotoxin | 518-28-5 | sc-204853 | 100 mg | $84.00 | 1 | |
This lignan inhibits microtubule assembly. Its binding to tubulin can impede the polymerization activity of TPPP2. | ||||||
Nocodazole | 31430-18-9 | sc-3518B sc-3518 sc-3518C sc-3518A | 5 mg 10 mg 25 mg 50 mg | $59.00 $85.00 $143.00 $247.00 | 38 | |
It disrupts microtubule polymer dynamics by depolymerizing microtubules, which can counter the polymerization facilitation by TPPP2. | ||||||
Combrestatin A4 | 117048-59-6 | sc-204697 sc-204697A | 1 mg 5 mg | $46.00 $81.00 | ||
This agent acts as an inhibitor of tubulin polymerization, which could negate the promoting effects of TPPP2 on tubulin assembly. | ||||||
Eribulin | 253128-41-5 | sc-507547 | 5 mg | $865.00 | ||
A microtubule dynamics inhibitor that prevents the growth phase of microtubule formation, potentially inhibiting TPPP2's role in microtubule polymerization. | ||||||
Griseofulvin | 126-07-8 | sc-202171A sc-202171 sc-202171B | 5 mg 25 mg 100 mg | $85.00 $220.00 $598.00 | 4 | |
Disrupts microtubule function by binding to tubulin, which might interfere with TPPP2's activity in microtubule assembly. | ||||||
Noscapine | 128-62-1 | sc-219418 | 10 mg | $102.00 | ||
It binds to tubulin and alters microtubule dynamics, which could counteract the tubulin polymerization promoted by TPPP2. | ||||||
Mebendazole | 31431-39-7 | sc-204798 sc-204798A | 5 g 25 g | $46.00 $89.00 | 2 | |
Disrupts microtubule synthesis, which can indirectly inhibit the polymerization activity of TPPP2. | ||||||