Topo I Inhibitors
Santa Cruz Biotechnology now offers a broad range of Topo I Inhibitors. DNA topoisomerase I and II (Topo I and Topo II) are nuclear enzymes that regulate the topological structure of DNA in eukaryotic cells by transiently breaking and rejoining DNA strands. Topo I Inhibitors offered by Santa Cruz inhibit Topo I and, in some cases, other DNA replication and recombination related proteins. View detailed Topo I Inhibitor specifications, including Topo I Inhibitor CAS number, molecular weight, molecular formula and chemical structure, by clicking on the product name.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Topotecan-d6 | 1044904-10-0 | sc-220273 | 1 mg | $380.00 | ||
Topotecan-d6 functions as a topoisomerase I inhibitor, characterized by its isotopic labeling that allows for advanced tracking in biochemical studies. Its structural features enable specific binding to the enzyme, disrupting the DNA relaxation process. The compound exhibits unique reaction kinetics, with a notable affinity for the enzyme's cleavable complex, leading to an accumulation of single-strand breaks. This behavior highlights its role in modulating DNA topology and enzyme dynamics. | ||||||
2′,3′-Dideoxyadenosine-5′-triphosphate Lithium Salt | 93939-70-9 | sc-288569 sc-288569A | 1 mg 5 mg | $237.00 $945.00 | ||
2',3'-Dideoxyadenosine-5'-triphosphate Lithium Salt acts as a potent topoisomerase I modulator, exhibiting unique interactions with the enzyme's active site. Its triphosphate moiety enhances binding affinity, facilitating the stabilization of transient enzyme-DNA complexes. This compound influences reaction kinetics by altering the equilibrium between DNA relaxation and supercoiling, ultimately impacting the enzyme's catalytic efficiency and the overall topology of nucleic acids. | ||||||