TNRC6C Activators
TNRC6C Activators are a specialized set of chemical entities that indirectly intensify the functional activity of TNRC6C through distinct cellular signaling mechanisms. Forskolin, by boosting intracellular cAMP, indirectly facilitates the assembly of the RNA-induced silencing complex (RISC), crucial for TNRC6C's role in miRNA-mediated gene silencing, thereby enhancing TNRC6C's activity. Genistein, through its action as a tyrosine kinase inhibitor, reduces competitive phosphorylation events, which could indirectly lead to an increased functional role of TNRC6C in gene silencing. Additionally, compounds like Sphingosine-1-phosphate and Thapsigargin modulate lipid and calcium signaling respectively, which can indirectly support the cytoskeletal organization and localization processes vital for TNRC6C's role in miRNA pathways.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Forskolin | 66575-29-9 | sc-3562 sc-3562A sc-3562B sc-3562C sc-3562D | 5 mg 50 mg 1 g 2 g 5 g | $78.00 $153.00 $740.00 $1413.00 $2091.00 | 73 | |
Forskolin elevates intracellular cAMP levels, which can enhance TNRC6C activity by promoting the assembly of the RNA-induced silencing complex (RISC), as TNRC6C is crucial for miRNA-mediated gene silencing. | ||||||
Genistein | 446-72-0 | sc-3515 sc-3515A sc-3515B sc-3515C sc-3515D sc-3515E sc-3515F | 100 mg 500 mg 1 g 5 g 10 g 25 g 100 g | $45.00 $164.00 $200.00 $402.00 $575.00 $981.00 $2031.00 | 46 | |
Genistein, as a tyrosine kinase inhibitor, indirectly enhances the functional activity of TNRC6C by reducing competitive phosphorylation events, thus favoring the miRNA pathway in which TNRC6C is a core component. | ||||||
D-erythro-Sphingosine-1-phosphate | 26993-30-6 | sc-201383 sc-201383D sc-201383A sc-201383B sc-201383C | 1 mg 2 mg 5 mg 10 mg 25 mg | $165.00 $322.00 $570.00 $907.00 $1727.00 | 7 | |
S1P modulates lipid signaling pathways that can lead to the reorganization of cytoskeletal elements, indirectly facilitating TNRC6C's role in the localization and processing of miRNAs within P-bodies. | ||||||
Thapsigargin | 67526-95-8 | sc-24017 sc-24017A | 1 mg 5 mg | $136.00 $446.00 | 114 | |
Thapsigargin raises intracellular calcium levels, which indirectly can enhance TNRC6C function by activating calcium-dependent signaling pathways critical for the miRNA pathway and RISC complex formation that involves TNRC6C. | ||||||
Staurosporine | 62996-74-1 | sc-3510 sc-3510A sc-3510B | 100 µg 1 mg 5 mg | $82.00 $153.00 $396.00 | 113 | |
Staurosporine is a broad-spectrum kinase inhibitor that can selectively enhance TNRC6C activity by inhibiting kinases that negatively regulate the miRNA-mediated gene silencing pathways where TNRC6C functions. | ||||||