TMEM158 Activators
TMEM158 Activators are chemical compounds that indirectly influence the activity of the TMEM158 (Transmembrane Protein 158) protein, which is a transmembrane protein with intricate cellular roles. These activators operate by targeting cellular processes and pathways closely associated with TMEM158 function. One significant avenue for TMEM158 activation involves the modulation of cellular trafficking and vesicular transport. Compounds like Brefeldin A disrupt the Golgi apparatus, indirectly influencing TMEM158 by altering the cellular organization of organelles and vesicular trafficking, which may intersect with TMEM158-related pathways. Similarly, Chloroquine, a lysosomotropic agent, affects TMEM158 by altering lysosomal function and trafficking processes that intersect with TMEM158-related functions. Additionally, Nocodazole, a microtubule inhibitor, indirectly affects TMEM158 by disrupting microtubule dynamics, leading to changes in cellular processes reliant on microtubule-dependent trafficking. These compounds collectively exemplify the class of TMEM158 activators, as they influence the protein's function through their impacts on cellular trafficking and organelle dynamics.
Another approach to TMEM158 activation involves the modulation of intracellular signaling pathways. Staurosporine, for example, is a broad-spectrum protein kinase inhibitor. Its application can indirectly influence TMEM158 by modulating cellular signaling pathways that intersect with TMEM158 regulation. These chemicals can indirectly impact TMEM158 by altering cellular signaling events that may regulate TMEM158 activity.
SEE ALSO...
| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Thapsigargin | 67526-95-8 | sc-24017 sc-24017A | 1 mg 5 mg | $136.00 $446.00 | 114 | |
Thapsigargin is a potent SERCA (sarco/endoplasmic reticulum calcium ATPase) inhibitor. Its use can indirectly affect TMEM158 by disrupting calcium homeostasis and ER-related processes that rely on TMEM158. | ||||||
Brefeldin A | 20350-15-6 | sc-200861C sc-200861 sc-200861A sc-200861B | 1 mg 5 mg 25 mg 100 mg | $31.00 $53.00 $124.00 $374.00 | 25 | |
Brefeldin A is a compound that disrupts the Golgi apparatus. Its application can indirectly influence TMEM158 by altering cellular trafficking and vesicular transport processes. | ||||||
Tunicamycin | 11089-65-9 | sc-3506A sc-3506 | 5 mg 10 mg | $172.00 $305.00 | 66 | |
Tunicamycin is an inhibitor of N-linked glycosylation. Its use can indirectly impact TMEM158 by altering protein modification and folding processes that are essential for its function. | ||||||
MG-132 [Z-Leu- Leu-Leu-CHO] | 133407-82-6 | sc-201270 sc-201270A sc-201270B | 5 mg 25 mg 100 mg | $60.00 $265.00 $1000.00 | 163 | |
MG-132 is a proteasome inhibitor. Its application can indirectly affect TMEM158 by influencing protein degradation pathways, potentially impacting TMEM158 turnover and function. | ||||||
Bafilomycin A1 | 88899-55-2 | sc-201550 sc-201550A sc-201550B sc-201550C | 100 µg 1 mg 5 mg 10 mg | $98.00 $255.00 $765.00 $1457.00 | 280 | |
Bafilomycin A1 is an inhibitor of the vacuolar-type H+-ATPase. Its use can indirectly influence TMEM158 by impacting lysosomal acidity and functions, which may be relevant to TMEM158 roles. | ||||||
Nocodazole | 31430-18-9 | sc-3518B sc-3518 sc-3518C sc-3518A | 5 mg 10 mg 25 mg 50 mg | $59.00 $85.00 $143.00 $247.00 | 38 | |
Nocodazole is a microtubule inhibitor. Its application can indirectly affect TMEM158 by disrupting microtubule dynamics and cellular processes that rely on microtubule-dependent trafficking. | ||||||
N-Ethylmaleimide | 128-53-0 | sc-202719A sc-202719 sc-202719B sc-202719C sc-202719D | 1 g 5 g 25 g 100 g 250 g | $22.00 $69.00 $214.00 $796.00 $1918.00 | 19 | |
NEM is a thiol-alkylating agent. Its use can indirectly impact TMEM158 by modifying cysteine residues and potentially altering protein structure and interactions associated with TMEM158. | ||||||
Monensin A | 17090-79-8 | sc-362032 sc-362032A | 5 mg 25 mg | $155.00 $525.00 | ||
Monensin is a sodium ionophore. Its application can indirectly influence TMEM158 by altering ion transport processes and potentially affecting TMEM158 functions related to ion homeostasis. | ||||||
Latrunculin A, Latrunculia magnifica | 76343-93-6 | sc-202691 sc-202691B | 100 µg 500 µg | $265.00 $815.00 | 36 | |
Latrunculin A is an actin filament disruptor. Its use can indirectly affect TMEM158 by disrupting actin-dependent cellular processes that may intersect with TMEM158-related pathways. | ||||||
Staurosporine | 62996-74-1 | sc-3510 sc-3510A sc-3510B | 100 µg 1 mg 5 mg | $82.00 $153.00 $396.00 | 113 | |
Staurosporine is a broad-spectrum protein kinase inhibitor. Its application can indirectly influence TMEM158 by modulating cellular signaling pathways that intersect with TMEM158 regulation. | ||||||