TMEM129 Inhibitors
MEM129 (Transmembrane Protein 129) is an E3 ubiquitin-protein ligase embedded within the cellular architecture as a type II transmembrane protein. It is significantly involved in the Endoplasmic Reticulum Associated Degradation (ERAD) pathway-a cellular quality control mechanism responsible for identifying and targeting misfolded proteins in the endoplasmic reticulum (ER) for proteasomal degradation. TMEM129 participates in this pathway by tagging defective proteins with ubiquitin molecules, a post-translational modification that marks them for removal by the proteasome, ensuring cellular homeostasis and proper protein function.
TMEM129's involvement in the ERAD pathway underscores its critical role in maintaining cellular integrity and functionality. Misfolded or improperly assembled proteins can disrupt cellular processes, lead to the aggregation of non-functional proteins, and induce cellular stress. By facilitating the degradation of such aberrant proteins, TMEM129 aids in preserving the balance and smooth operation of cellular protein machinery.In conclusion, TMEM129 is a crucial component of the cellular ubiquitination and degradation system, ensuring that proteins within the cell maintain their integrity, functionality, and proper conformation. Its role is pivotal in inhibiting the accumulation of misfolded proteins, thereby aiding in the maintenance of cellular health and the inhibition of protein aggregation-related stress and cellular dysfunctions.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
MG-132 [Z-Leu- Leu-Leu-CHO] | 133407-82-6 | sc-201270 sc-201270A sc-201270B | 5 mg 25 mg 100 mg | $56.00 $260.00 $980.00 | 163 | |
May inhibit proteasomal activity, potentially affecting the degradation processes where TMEM129 is involved. | ||||||
Bortezomib | 179324-69-7 | sc-217785 sc-217785A | 2.5 mg 25 mg | $132.00 $1064.00 | 115 | |
Inhibits proteasomal activity, possibly affecting TMEM129-mediated ubiquitination and subsequent protein degradation. | ||||||
Lactacystin | 133343-34-7 | sc-3575 sc-3575A | 200 µg 1 mg | $165.00 $575.00 | 60 | |
May block proteasomal degradation, potentially impacting TMEM129's role in the ERAD pathway. | ||||||
Epoxomicin | 134381-21-8 | sc-201298C sc-201298 sc-201298A sc-201298B | 50 µg 100 µg 250 µg 500 µg | $134.00 $215.00 $440.00 $496.00 | 19 | |
A proteasome inhibitor that may impact TMEM129's function in protein ubiquitination and degradation. | ||||||
Calpeptin | 117591-20-5 | sc-202516 sc-202516A | 10 mg 50 mg | $119.00 $447.00 | 28 | |
Might inhibit the proteasome, possibly affecting TMEM129-mediated protein degradation pathways. | ||||||
MLN 4924 | 905579-51-3 | sc-484814 | 1 mg | $280.00 | 1 | |
By inhibiting NEDD8-activating enzyme, it could impact ubiquitination processes involving TMEM129. | ||||||
MLN7243 | 1450833-55-2 | sc-507338 | 5 mg | $340.00 | ||
May inhibit ubiquitination, potentially affecting TMEM129's function in the ERAD pathway. | ||||||
Ubiquitin E1 Inhibitor, PYR-41 | 418805-02-4 | sc-358737 | 25 mg | $360.00 | 4 | |
An ubiquitin-activating enzyme inhibitor that might influence TMEM129's ubiquitination activities. | ||||||
P22077 | 1247819-59-5 | sc-478536 | 10 mg | $162.00 | ||
May inhibit deubiquitinating enzymes, potentially impacting the ubiquitination processes mediated by TMEM129. | ||||||
NSC697923 | 343351-67-7 | sc-391107 sc-391107A | 1 mg 5 mg | $15.00 $51.00 | 3 | |
Could inhibit the ubiquitination process, possibly affecting TMEM129's role in protein degradation. | ||||||