Tim13B Activators
Tim13B is a mitochondrial protein that plays a crucial role in the complex network of cellular processes that maintain mitochondrial function and bioenergetics. As a component of the translocase of the inner mitochondrial membrane (TIM) complex, Tim13B is specifically involved in the import and insertion of protein substrates essential for mitochondrial operation. Understanding the regulation of Tim13B is of significant interest in the field of cellular biology, as it offers insights into the mechanisms governing mitochondrial health and resilience. The expression of Tim13B is tightly controlled within the cell, and certain biochemical compounds have been identified as potential activators that can upregulate the synthesis of this protein. These activators may interact with cellular signaling pathways and transcription factors that are directly or indirectly involved in the mitochondrial stress response and biogenesis.
Studies have suggested that compounds such as resveratrol, a polyphenolic compound found in grapes, could upregulate Tim13B by activating sirtuin pathways, which are known to stimulate mitochondrial biogenesis and function. Similarly, metformin, commonly recognized for its role in glucose metabolism, may promote Tim13B expression through the activation of AMP-activated protein kinase (AMPK), a key energy sensor in cells that regulates energy homeostasis. Nicotinamide mononucleotide (NMN) and Coenzyme Q10 are other molecules of interest, with NMN enhancing NAD+ levels, thus potentially encouraging the synthesis of Tim13B, and Coenzyme Q10 being integral to the electron transport chain, possibly promoting Tim13B expression as part of its role in maintaining mitochondrial integrity. Additionally, natural compounds such as alpha-lipoic acid and spermidine have been associated with the induction of mitochondrial autophagy and mitophagy, which can lead to the renewal of mitochondrial components, including Tim13B. These findings represent a growing body of research focused on the cellular mechanisms that can initiate the upregulation of Tim13B, offering a window into the maintenance and optimization of mitochondrial function.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Resveratrol | 501-36-0 | sc-200808 sc-200808A sc-200808B | 100 mg 500 mg 5 g | $60.00 $185.00 $365.00 | 64 | |
Resveratrol may activate sirtuin pathways, specifically SIRT1, which is known to play a role in mitochondrial biogenesis. This activation could lead to the upregulation of mitochondrial proteins, potentially including Tim13B, as part of the cellular response to enhance mitochondrial function and energy efficiency. | ||||||
Metformin | 657-24-9 | sc-507370 | 10 mg | $77.00 | 2 | |
Metformin is known to stimulate AMP-activated protein kinase (AMPK), which in turn could initiate a cascade leading to the increased transcription of genes encoding mitochondrial proteins. This process might include the upregulation of Tim13B, as it is essential for mitochondrial protein import and membrane translocation. | ||||||
β-Nicotinamide mononucleotide | 1094-61-7 | sc-212376 sc-212376A sc-212376B sc-212376C sc-212376D | 25 mg 100 mg 1 g 2 g 5 g | $92.00 $269.00 $337.00 $510.00 $969.00 | 4 | |
β-Nicotinamide mononucleotide serves as a precursor for NAD+, which is crucial for mitochondrial health and energy metabolism. By elevating NAD+ levels, NMN could stimulate the production of mitochondrial proteins, potentially including the enhancement of Tim13B levels, due to its role in maintaining mitochondrial integrity. | ||||||
D,L-Sulforaphane | 4478-93-7 | sc-207495A sc-207495B sc-207495C sc-207495 sc-207495E sc-207495D | 5 mg 10 mg 25 mg 1 g 10 g 250 mg | $150.00 $286.00 $479.00 $1299.00 $8299.00 $915.00 | 22 | |
DL-Sulforaphane can activate antioxidant response elements through the Keap1-Nrf2 pathway. By stimulating this pathway, it may lead to the upregulation of genes encoding protective mitochondrial proteins, which could encompass the increased synthesis of Tim13B, providing a buffer against oxidative mitochondrial damage. | ||||||
Coenzyme Q10 | 303-98-0 | sc-205262 sc-205262A | 1 g 5 g | $70.00 $180.00 | 1 | |
Coenzyme Q10 is a vital component of the electron transport chain that could have a role in the stabilization and functional optimization of mitochondria. Its presence may be essential for the upregulation of proteins like Tim13B, which are integral to mitochondrial protein import machinery. | ||||||
α-Lipoic Acid | 1077-28-7 | sc-202032 sc-202032A sc-202032B sc-202032C sc-202032D | 5 g 10 g 250 g 500 g 1 kg | $68.00 $120.00 $208.00 $373.00 $702.00 | 3 | |
α-Lipoic Acid, as a coenzyme in the mitochondrial energy conversion process, has the potential to stimulate the expression of mitochondrial proteins, including Tim13B. This stimulation could be due to its involvement in the management of reactive oxygen species and its role in the repair of oxidative damage within mitochondria. | ||||||
Spermidine | 124-20-9 | sc-215900 sc-215900B sc-215900A | 1 g 25 g 5 g | $56.00 $595.00 $173.00 | ||
Spermidine has been linked to the promotion of autophagy and mitophagy, which are processes related to the turnover and renewal of mitochondrial components. This promotion could lead to the upregulation of mitochondrial chaperones, such as Tim13B, as part of the cellular effort to maintain mitochondrial quality control. | ||||||
N-Acetyl-L-cysteine | 616-91-1 | sc-202232 sc-202232A sc-202232C sc-202232B | 5 g 25 g 1 kg 100 g | $33.00 $73.00 $265.00 $112.00 | 34 | |
N-Acetyl-L-cysteine, by providing cysteine for glutathione synthesis, could enhance the antioxidant defenses within mitochondria. This enhancement might stimulate the expression of mitochondrial chaperones like Tim13B, as the cells attempt to bolster their defenses against oxidative mitochondrial damage. | ||||||
Bezafibrate | 41859-67-0 | sc-204650B sc-204650 sc-204650A sc-204650C | 500 mg 1 g 5 g 10 g | $30.00 $45.00 $120.00 $200.00 | 5 | |
Bezafibrate, as a fibrate drug, can upregulate the transcription of genes involved in mitochondrial biogenesis and energy expenditure. Consequently, this upregulation could include the increased expression of Tim13B, due to its necessity in facilitating the entry and assembly of proteins in the mitochondrial inner membrane. | ||||||
Melatonin | 73-31-4 | sc-207848 sc-207848A sc-207848B sc-207848C sc-207848D sc-207848E | 1 g 5 g 25 g 100 g 250 g 1 kg | $64.00 $72.00 $214.00 $683.00 $1173.00 $3504.00 | 16 | |
Melatonin possesses both antioxidant and mitochondria-protective properties. These properties allow it to potentially stimulate the expression of proteins that contribute to mitochondrial resilience, including Tim13B, as part of the cellular defense mechanism against circadian-related oxidative stress. | ||||||