TFIIH p34 Activators
TFIIH p34 is a subunit of the Transcription Factor II Human (TFIIH) complex, which is essential for two critical cellular processes: transcription and nucleotide excision repair (NER). The p34 subunit is one of several proteins that make up this complex, and although it is not as extensively characterized as some of the other components, it plays a role in the complex's functions and stability.The TFIIH complex has dual functionality. In transcription, it is involved in the initiation phase of RNA polymerase II-dependent transcription. TFIIH helps to unwind DNA at the transcription start site, allowing the polymerase to access the single-stranded DNA template. This is facilitated by the helicase activity inherent within the TFIIH complex.
In DNA repair, specifically NER, TFIIH is crucial for the recognition and correction of bulky helix-distorting lesions, such as those caused by ultraviolet (UV) radiation. The helicase activity of TFIIH is again central here, as it unwinds the DNA around the site of damage, permitting other repair proteins to excise the defective strand and synthesize a correct one.The p34 subunit is thought to contribute to the structural integrity and proper assembly of the TFIIH complex. While the exact mechanisms by which p34 functions are not fully understood, it is clear that the integrity of TFIIH as a whole is necessary for its involvement in both transcription and DNA repair.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Suberoylanilide Hydroxamic Acid | 149647-78-9 | sc-220139 sc-220139A | 100 mg 500 mg | $130.00 $270.00 | 37 | |
Vorinostat, another histone deacetylase inhibitor, modifies chromatin structure, potentially affecting TFIIH complex function. | ||||||
Caffeine | 58-08-2 | sc-202514 sc-202514A sc-202514B sc-202514C sc-202514D | 5 g 100 g 250 g 1 kg 5 kg | $32.00 $66.00 $95.00 $188.00 $760.00 | 13 | |
Caffeine, by inhibiting ATM and ATR kinases, influences DNA repair pathways where TFIIH is involved, potentially modifying GTF2H3 activity. | ||||||
Olaparib | 763113-22-0 | sc-302017 sc-302017A sc-302017B | 250 mg 500 mg 1 g | $206.00 $299.00 $485.00 | 10 | |
Olaparib, a PARP inhibitor, influences DNA repair mechanisms, which could indirectly affect GTF2H3's role in the TFIIH complex. | ||||||
Camptothecin | 7689-03-4 | sc-200871 sc-200871A sc-200871B | 50 mg 250 mg 100 mg | $57.00 $182.00 $92.00 | 21 | |
Camptothecin, a topoisomerase I inhibitor, impacts DNA replication and repair, potentially influencing GTF2H3 activity in TFIIH. | ||||||
Cycloheximide | 66-81-9 | sc-3508B sc-3508 sc-3508A | 100 mg 1 g 5 g | $40.00 $82.00 $256.00 | 127 | |
Cycloheximide, a protein synthesis inhibitor, may indirectly influence GTF2H3 by altering cellular protein levels and transcription dynamics. | ||||||
(−)-Epigallocatechin Gallate | 989-51-5 | sc-200802 sc-200802A sc-200802B sc-200802C sc-200802D sc-200802E | 10 mg 50 mg 100 mg 500 mg 1 g 10 g | $42.00 $72.00 $124.00 $238.00 $520.00 $1234.00 | 11 | |
This compound, a major component of green tea, has been shown to affect DNA repair mechanisms, potentially impacting GTF2H3. | ||||||
Curcumin | 458-37-7 | sc-200509 sc-200509A sc-200509B sc-200509C sc-200509D sc-200509F sc-200509E | 1 g 5 g 25 g 100 g 250 g 1 kg 2.5 kg | $36.00 $68.00 $107.00 $214.00 $234.00 $862.00 $1968.00 | 47 | |
Curcumin influences various signaling pathways, possibly affecting TFIIH complex and GTF2H3 activity. | ||||||
Resveratrol | 501-36-0 | sc-200808 sc-200808A sc-200808B | 100 mg 500 mg 5 g | $60.00 $185.00 $365.00 | 64 | |
Resveratrol, a polyphenol, may indirectly affect GTF2H3 through its action on sirtuins and influence on DNA repair processes. | ||||||
D,L-Sulforaphane | 4478-93-7 | sc-207495A sc-207495B sc-207495C sc-207495 sc-207495E sc-207495D | 5 mg 10 mg 25 mg 1 g 10 g 250 mg | $150.00 $286.00 $479.00 $1299.00 $8299.00 $915.00 | 22 | |
Sulforaphane, a compound in cruciferous vegetables, may influence GTF2H3 activity indirectly through its effects on cellular stress pathways. | ||||||
Fluorouracil | 51-21-8 | sc-29060 sc-29060A | 1 g 5 g | $36.00 $149.00 | 11 | |
As an antimetabolite, 5-Fluorouracil affects DNA synthesis and repair, potentially influencing GTF2H3 in the TFIIH complex. | ||||||