TEX33 inhibitors are a class of chemical compounds that specifically target the TEX33 protein, a member of the testis-expressed protein family. TEX33, though predominantly expressed in testicular tissue, has been identified as playing a role in various cellular processes, including protein interactions and potentially in the regulation of gene expression during meiosis and other cell-specific functions. TEX33 is characterized by its distinct domain architecture, which allows it to engage with other proteins, contributing to complex cellular networks. Inhibitors of TEX33 work by disrupting these protein-protein interactions, interfering with its ability to function within these cellular networks. This disruption could alter the molecular dynamics within cells, affecting the pathways that depend on TEX33's proper functioning.
By inhibiting TEX33, these compounds can impact several key biological processes associated with its function in testis-specific or broader cellular contexts. TEX33 may play a role in the coordination of protein assembly or localization within certain cell types, and its inhibition can disrupt these processes. This disruption can manifest in altered protein homeostasis or signal transduction, leading to potential downstream effects on cellular function. Furthermore, TEX33's involvement in cellular pathways that are not fully elucidated makes inhibitors of this protein valuable tools for studying its exact molecular role. By selectively targeting TEX33, researchers can gain insights into its biochemical interactions and better understand the broader impact of testis-expressed proteins on cellular biology. The specificity of these inhibitors allows for detailed investigation into the cellular mechanisms regulated by TEX33, providing a deeper understanding of its contributions to cellular organization and function.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Cycloheximide | 66-81-9 | sc-3508B sc-3508 sc-3508A | 100 mg 1 g 5 g | $40.00 $82.00 $256.00 | 127 | |
Cycloheximide inhibits eukaryotic protein synthesis, potentially decreasing the expression of ciliary microtubule-associated proteins. | ||||||
Rapamycin | 53123-88-9 | sc-3504 sc-3504A sc-3504B | 1 mg 5 mg 25 mg | $62.00 $155.00 $320.00 | 233 | |
Rapamycin inhibits mTOR, a kinase involved in protein synthesis; this could reduce the expression of proteins essential for cilia function. | ||||||
Doxorubicin | 23214-92-8 | sc-280681 sc-280681A | 1 mg 5 mg | $173.00 $418.00 | 43 | |
Doxorubicin intercalates DNA, potentially disrupting transcription and thus inhibiting protein expression related to cilia. | ||||||
Actinomycin D | 50-76-0 | sc-200906 sc-200906A sc-200906B sc-200906C sc-200906D | 5 mg 25 mg 100 mg 1 g 10 g | $73.00 $238.00 $717.00 $2522.00 $21420.00 | 53 | |
Actinomycin D binds to DNA and halts mRNA synthesis, which can inhibit the expression of ciliary proteins. | ||||||
Chloroquine | 54-05-7 | sc-507304 | 250 mg | $68.00 | 2 | |
Chloroquine can alter endosomal and lysosomal pH, which might affect protein trafficking and expression in ciliary assembly. | ||||||
5-Azacytidine | 320-67-2 | sc-221003 | 500 mg | $280.00 | 4 | |
5-Azacytidine incorporates into RNA and DNA, potentially modulating gene expression patterns, including those for ciliary proteins. | ||||||
Taxol | 33069-62-4 | sc-201439D sc-201439 sc-201439A sc-201439E sc-201439B sc-201439C | 1 mg 5 mg 25 mg 100 mg 250 mg 1 g | $40.00 $73.00 $217.00 $242.00 $724.00 $1196.00 | 39 | |
Paclitaxel stabilizes microtubules and could disrupt the dynamic needed for proper cilia function and protein expression. | ||||||
Vinblastine | 865-21-4 | sc-491749 sc-491749A sc-491749B sc-491749C sc-491749D | 10 mg 50 mg 100 mg 500 mg 1 g | $100.00 $230.00 $450.00 $1715.00 $2900.00 | 4 | |
Vinblastine binds to tubulin and disrupts microtubule assembly, which could inhibit ciliary protein expression. | ||||||
Colchicine | 64-86-8 | sc-203005 sc-203005A sc-203005B sc-203005C sc-203005D sc-203005E | 1 g 5 g 50 g 100 g 500 g 1 kg | $98.00 $315.00 $2244.00 $4396.00 $17850.00 $34068.00 | 3 | |
Colchicine binds to tubulin, preventing microtubule polymerization, which may inhibit ciliary protein assembly and expression. | ||||||
Nocodazole | 31430-18-9 | sc-3518B sc-3518 sc-3518C sc-3518A | 5 mg 10 mg 25 mg 50 mg | $58.00 $83.00 $140.00 $242.00 | 38 | |
Nocodazole disrupts microtubule polymerization and could lead to reduced expression of proteins required for cilia structure. | ||||||