TEM5 Activators
TEM5 activators are a category of chemical agents that interact with the TEM5 protein, also known as G-protein-coupled receptor 124 (GPR124), part of the adhesion G protein-coupled receptor (GPCR) family. These activators are recognized for their role in modulating the function of this protein by influencing its signaling pathways. The TEM5/GPR124 is an integral membrane protein that is involved in various cellular mechanisms and is expressed in several tissue types. The specific biochemical pathways that TEM5 activators target are complex and involve a variety of intracellular signaling cascades. These cascades are initiated upon the binding of the activators to the receptor, which then undergoes a conformational change that triggers the intracellular response.
In biochemical terms, TEM5 activators can be small molecules, peptides, or other types of ligands that have a high affinity for the GPR124 receptor. The binding of these activators to the receptor is a highly selective process, often involving specific domains of the GPR124 protein that are critical for its activation. The interaction between TEM5 activators and the GPR124 receptor can lead to the modulation of the receptor's activity, altering the downstream signaling processes that it regulates. This modulation is key to the function of TEM5 activators, as it influences the cellular responses that are controlled by the TEM5 protein, including those involved in the regulation of cellular adhesion, proliferation, and migration. Understanding the precise mechanisms by which these activators function is a subject of intensive research, focusing on the molecular dynamics between the activator molecules and the receptor, as well as the subsequent signaling pathways that are engaged.
| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Forskolin | 66575-29-9 | sc-3562 sc-3562A sc-3562B sc-3562C sc-3562D | 5 mg 50 mg 1 g 2 g 5 g | $78.00 $153.00 $740.00 $1413.00 $2091.00 | 73 | |
Forskolin directly stimulates adenylyl cyclase, resulting in increased levels of cAMP, a second messenger that can enhance protein kinase A (PKA) activity. PKA phosphorylation events can lead to the activation of proteins involved in cell adhesion and migration, processes in which TEM5 is implicated. | ||||||
PMA | 16561-29-8 | sc-3576 sc-3576A sc-3576B sc-3576C sc-3576D | 1 mg 5 mg 10 mg 25 mg 100 mg | $41.00 $132.00 $214.00 $500.00 $948.00 | 119 | |
PMA activates protein kinase C (PKC), which can phosphorylate a multitude of proteins. PKC-mediated phosphorylation can influence integrin signaling, a pathway that TEM5 may be associated with due to its role in cellular adhesion. | ||||||
D-erythro-Sphingosine-1-phosphate | 26993-30-6 | sc-201383 sc-201383D sc-201383A sc-201383B sc-201383C | 1 mg 2 mg 5 mg 10 mg 25 mg | $165.00 $322.00 $570.00 $907.00 $1727.00 | 7 | |
S1P engages with its G protein-coupled receptors to initiate a signaling cascade that promotes cytoskeletal rearrangements and cell migration, processes that TEM5 is likely involved in, given its role in cellular dynamics. | ||||||
Lysophosphatidic Acid | 325465-93-8 | sc-201053 sc-201053A | 5 mg 25 mg | $98.00 $341.00 | 50 | |
LPA interacts with its G protein-coupled receptors, yielding cellular responses such as migration and survival, which are processes that could be mediated by TEM5 in its cellular context. | ||||||
Fibronectin | sc-29011 sc-29011A | 1 mg 5 mg | $143.00 $504.00 | 94 | ||
Fibronectin is a glycoprotein that can activate integrin signaling pathways upon cell adhesion. This can lead to actin cytoskeletal reorganization and enhanced cell migration, possibly involving the functional activity of TEM5. | ||||||
β-Nicotinamide adenine dinucleotide phosphate | 53-59-8 | sc-215560 sc-215560A | 100 mg 250 mg | $182.00 $319.00 | ||
NADPH is a cofactor in oxidative reactions and is involved in the production of reactive oxygen species (ROS) through NADPH oxidase. ROS can modulate cellular signaling pathways including those regulating cell migration, where TEM5 could be functionally active. | ||||||
A23187 | 52665-69-7 | sc-3591 sc-3591B sc-3591A sc-3591C | 1 mg 5 mg 10 mg 25 mg | $55.00 $131.00 $203.00 $317.00 | 23 | |
Calcium ionophores increase intracellular calcium concentration, which can activate calcium-dependent proteins and pathways. This might enhance TEM5 function as calcium signaling is often implicated in the regulation of cell adhesion and migration. | ||||||