TBL1XR1 Activators

The chemical class TBL1XR1 Activators encompasses a wide range of compounds that indirectly influence the activity of TBL1XR1, a protein involved in gene transcription and nuclear receptor signaling. These compounds primarily act through their ability to modulate gene transcription or to influence the signaling pathways of nuclear receptors.

Retinoic acid, estradiol, dexamethasone, tamoxifen, mifepristone, and rosiglitazone represent a subset of these activators acting through nuclear receptor signaling. These compounds are known to interact with various nuclear receptors, including the retinoic acid receptor, estrogen receptor, glucocorticoid receptor, and PPARγ. Their activity on these receptors can alter gene transcription, indirectly influencing the activity of TBL1XR1, which is known to interact with nuclear receptors. On the other hand, ATRA, JQ1, SAHA, Trichostatin A, 5-Azacytidine, and EGCG represent a group of TBL1XR1 activators that primarily modulate gene transcription. These compounds include inhibitors of the BET family of bromodomain proteins and histone deacetylases, as well as a nucleoside analogue of cytidine that inhibits DNA methylation.