Tb15a inhibitors are a class of chemical compounds that specifically target the Tb15a protein, a transcription factor known to play an important role in regulating gene expression during various cellular processes, including differentiation, proliferation, and cellular response to environmental signals. Tb15a is involved in the modulation of specific gene networks by binding to DNA at regulatory regions, influencing the transcription of target genes. It is primarily associated with controlling genes that are key to developmental processes and cell cycle regulation. Inhibiting Tb15a function disrupts its ability to bind to DNA or interact with other transcriptional co-factors, thereby altering the gene expression patterns necessary for normal cellular function.
The mechanism of action for Tb15a inhibitors typically involves binding to the DNA-binding domain of the protein or interfering with its interaction with transcriptional machinery, preventing it from activating or repressing its target genes. This can lead to a cascade of changes in cellular activities, as the genes under the control of Tb15a are often involved in critical cellular processes. By inhibiting Tb15a, these compounds are valuable tools for exploring the molecular mechanisms by which transcription factors regulate developmental and cellular pathways. Tb15a inhibitors allow researchers to investigate the broader impact of transcriptional regulation on cell behavior and understand how disruptions in these pathways contribute to altered cellular states. These inhibitors also provide insight into the precise role of Tb15a in coordinating complex gene networks during critical stages of development and cell cycle progression.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Staurosporine | 62996-74-1 | sc-3510 sc-3510A sc-3510B | 100 µg 1 mg 5 mg | $82.00 $150.00 $388.00 | 113 | |
Could directly compete with ATP for the active site on Tb15a, leading to a decrease in its kinase activity. | ||||||
Rapamycin | 53123-88-9 | sc-3504 sc-3504A sc-3504B | 1 mg 5 mg 25 mg | $62.00 $155.00 $320.00 | 233 | |
May downregulate Tb15a by inhibiting mTOR, a kinase that can control the translation of specific mRNAs. | ||||||
5-Azacytidine | 320-67-2 | sc-221003 | 500 mg | $280.00 | 4 | |
Could induce DNA demethylation, which may lead to the suppression of Tb15a gene transcription. | ||||||
Trichostatin A | 58880-19-6 | sc-3511 sc-3511A sc-3511B sc-3511C sc-3511D | 1 mg 5 mg 10 mg 25 mg 50 mg | $149.00 $470.00 $620.00 $1199.00 $2090.00 | 33 | |
May disrupt histone deacetylation, causing chromatin remodeling that could result in a decrease in Tb15a transcription. | ||||||
SP600125 | 129-56-6 | sc-200635 sc-200635A | 10 mg 50 mg | $40.00 $150.00 | 257 | |
Could obstruct JNK pathway signaling, potentially leading to a reduced transcription rate of the Tb15a gene. | ||||||
LY 294002 | 154447-36-6 | sc-201426 sc-201426A | 5 mg 25 mg | $121.00 $392.00 | 148 | |
May block PI3K signaling, resulting in the downregulation of downstream genes, including Tb15a. | ||||||
PD 98059 | 167869-21-8 | sc-3532 sc-3532A | 1 mg 5 mg | $39.00 $90.00 | 212 | |
Might inhibit MEK enzymes, potentially leading to reduced transcription of genes controlled by the MAPK/ERK pathway, such as Tb15a. | ||||||
Actinomycin D | 50-76-0 | sc-200906 sc-200906A sc-200906B sc-200906C sc-200906D | 5 mg 25 mg 100 mg 1 g 10 g | $73.00 $238.00 $717.00 $2522.00 $21420.00 | 53 | |
Could bind to DNA and obstruct RNA polymerase movement, leading to a reduction in Tb15a mRNA synthesis. | ||||||
Cycloheximide | 66-81-9 | sc-3508B sc-3508 sc-3508A | 100 mg 1 g 5 g | $40.00 $82.00 $256.00 | 127 | |
May block peptide elongation during mRNA translation, resulting in decreased synthesis of the Tb15a protein. | ||||||
U-0126 | 109511-58-2 | sc-222395 sc-222395A | 1 mg 5 mg | $63.00 $241.00 | 136 | |
Might selectively inhibit MEK1/2, leading to a decrease in the expression levels of genes regulated by the MAPK/ERK pathway, potentially including Tb15a. | ||||||