Tas2r140 Activators
Chemical activators of Tas2r140 include a variety of compounds, all recognized for their bitter taste, which is a key indicator of their potential to directly interact with and activate this bitter taste receptor. Denatonium benzoate, one of the most bitter compounds known, serves as an activator by binding to Tas2r140, resulting in receptor conformational change and subsequent initiation of intracellular taste signal transduction. Similarly, quinine, found in tonic water, activates Tas2r140 through direct interaction with the receptor's ligand-binding domain, promoting activation of the G-protein coupled signaling pathway integral to bitter taste perception. Phenylthiocarbamide (PTC) and Propylthiouracil (PROP) both act on Tas2r140 through direct binding, which is known to initiate the signaling pathway necessary for the perception of bitterness. These chemicals are distinct in their ability to be tasted as bitter by individuals who possess specific forms of the Tas2r140 receptor.
Continuing with the activation mechanism, absinthin and amarogentin, both extremely bitter substances, activate Tas2r140 by directly binding to the receptor, which in turn activates the signal transduction mechanisms. Salicin, a bitter-tasting compound from willow bark, and sucrose octaacetate, also known for its bitterness, activate Tas2r140 by direct receptor interaction, leading to the activation of signaling pathways responsible for the perception of bitterness. Parthenolide and colchicine, despite their different origins, activate the receptor in a similar manner through direct binding, triggering intracellular signaling required for bitter taste perception. Aloin, from aloe, and caffeine, a well-known bitter compound, activate Tas2r140 by direct interaction, which leads to the activation of the taste signaling pathways that communicate the sensation of bitterness to the brain. Each of these chemicals has a unique structure that enables it to bind to Tas2r140, thereby activating the receptor and its associated signaling pathways.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Denatonium benzoate | 3734-33-6 | sc-234525 sc-234525A sc-234525B sc-234525C sc-234525D | 1 g 5 g 25 g 100 g 250 g | $32.00 $47.00 $141.00 $473.00 $921.00 | ||
Denatonium benzoate is known as one of the most bitter compounds and Tas2r140 is a bitter taste receptor. Binding of denatonium benzoate to Tas2r140 leads to the activation of the receptor, which in turn initiates a cascade of intracellular events resulting in taste signal transduction. | ||||||
Quinine | 130-95-0 | sc-212616 sc-212616A sc-212616B sc-212616C sc-212616D | 1 g 5 g 10 g 25 g 50 g | $79.00 $104.00 $166.00 $354.00 $572.00 | 1 | |
Quinine is a natural compound known for its bitter taste. It activates Tas2r140 by binding to the receptor's ligand-binding domain, causing a change in the receptor's conformation and activating the G-protein coupled signaling pathway associated with taste perception. | ||||||
N-Phenylthiourea | 103-85-5 | sc-236086 | 100 g | $319.00 | ||
Phenylthiocarbamide is a compound that tastes extremely bitter to those with a particular variation of the Tas2r140 receptor. It activates Tas2r140 by directly binding to it, which triggers the signaling pathway necessary for bitter taste perception. | ||||||
6-Propyl-2-thiouracil | 51-52-5 | sc-214383 sc-214383A sc-214383B sc-214383C | 10 g 25 g 100 g 1 kg | $37.00 $56.00 $224.00 $1997.00 | ||
Propylthiouracil is structurally similar to PTC and also activates Tas2r140 by directly interacting with the receptor, resulting in the activation of downstream signaling mechanisms involved in taste sensation. | ||||||
D-(−)-Salicin | 138-52-3 | sc-218004 | 5 g | $59.00 | ||
Salicin, a bitter-tasting compound found in willow bark, activates Tas2r140 by direct interaction with the receptor, leading to the activation of the signaling pathways responsible for the perception of bitterness. | ||||||
Parthenolide | 20554-84-1 | sc-3523 sc-3523A | 50 mg 250 mg | $81.00 $306.00 | 32 | |
Parthenolide, a sesquiterpene lactone from feverfew, activates Tas2r140 by binding to the ligand-binding sites on the receptor, leading to activation of the taste signal transduction pathway. | ||||||
Colchicine | 64-86-8 | sc-203005 sc-203005A sc-203005B sc-203005C sc-203005D sc-203005E | 1 g 5 g 50 g 100 g 500 g 1 kg | $100.00 $321.00 $2289.00 $4484.00 $18207.00 $34749.00 | 3 | |
Colchicine, known for its medicinal properties and bitter taste, activates Tas2r140 by directly binding to the receptor, which triggers the intracellular signaling required for bitter taste perception. | ||||||
Aloin | 1415-73-2 | sc-214525 sc-214525A | 25 mg 100 mg | $159.00 $271.00 | 1 | |
Aloin, a bitter compound derived from aloe, activates Tas2r140 by direct interaction with the receptor, leading to the activation of bitter taste signaling pathways. | ||||||
Caffeine | 58-08-2 | sc-202514 sc-202514A sc-202514B sc-202514C sc-202514D | 50 g 100 g 250 g 1 kg 5 kg | $33.00 $67.00 $97.00 $192.00 $775.00 | 13 | |
Caffeine, a bitter-tasting methylxanthine, activates Tas2r140 by binding to the receptor, which in turn activates the associated G-protein and initiates the bitter taste signaling cascade. | ||||||