TARSH Activators

ABI Family Member 3 Binding Protein, commonly known as ABI3BP, is a human protein encoded by the ABI3BP gene. This protein is an extracellular matrix component that plays a critical role in cellular processes such as differentiation, proliferation, and migration. ABI3BP is particularly recognized for its involvement in the regulation of actin cytoskeleton dynamics and its interactions with the Abl interactor (ABI) family of proteins, which are known to engage in signaling pathways that control cell motility and cytoskeletal reorganization.

The ABI3BP protein is characterized by the presence of an N-terminal N-ABI domain, which is responsible for binding to the ABI family members, and a series of Fasciclin 1 (FAS1) domains in its extracellular matrix region. These domains suggest that ABI3BP has a function in cell adhesion and communication with the extracellular environment. The interaction between ABI3BP and the ABI family proteins is believed to influence actin polymerization and branching, processes that are fundamental for the formation of lamellipodia and filopodia during cell movement.Moreover, ABI3BP has been implicated in the regulation of cellular senescence, as it is often found to be downregulated in various types of cancer cells, suggesting a potential tumor suppressor role. The restoration of its expression in these cells has been associated with the inhibition of proliferation and the induction of senescence, highlighting its importance in maintaining tissue homeostasis and preventing uncontrolled cell growth.