TAF II p150 Inhibitors
The chemical class termed TAF II p150 Inhibitors encompasses a diverse range of compounds that, while not directly targeting the TAF II p150 protein, can influence its activity through modulation of the chromatin landscape and transcription regulation mechanisms. These compounds include inhibitors of enzymes that modify DNA and histones, such as DNA methyltransferases, histone deacetylases (HDACs), histone acetyltransferases (HATs), and histone methyltransferases (HMTs), as well as molecules that interfere with the function of proteins reading epigenetic marks, like bromodomain-containing proteins.
These chemicals operate by altering the structural framework of chromatin, which in turn can modulate the assembly and function of transcription complexes that include TAF II p150. For instance, HDAC inhibitors like Trichostatin A, SAHA, Entinostat, and Mocetinostat increase acetylation levels of histones, leading to a more open chromatin conformation that can affect the recruitment and stability of transcription factor complexes to which TAF II p150 belongs. Similarly, DNA methyltransferase inhibitors like 5-Azacytidine and RG108 can result in DNA hypomethylation, which might lead to changes in gene expression profiles and influence the binding of transcription factors. Furthermore, compounds like C646 that inhibit HATs, such as p300, can decrease histone acetylation levels, possibly impacting the assembly of transcription factor complexes. Bromodomain inhibitors like JQ1 and I-BET151 inhibit the interaction between acetylated histones and BET proteins, which is crucial for the regulation of gene expression. By disrupting these interactions, the transcriptional machinery can be significantly affected, thereby altering the functional context in which TAF II p150 operates. The extensive network of transcriptional regulation is tightly controlled by epigenetic modifications, and these compounds provide a means of modulating such modifications.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Triptolide | 38748-32-2 | sc-200122 sc-200122A | 1 mg 5 mg | $90.00 $204.00 | 13 | |
Triptolide is a diterpene triepoxide that interferes with transcription by covalently modifying the XPB subunit of TFIIH, which is part of the transcription pre-initiation complex that includes TAF II p150. | ||||||
DRB | 53-85-0 | sc-200581 sc-200581A sc-200581B sc-200581C | 10 mg 50 mg 100 mg 250 mg | $43.00 $189.00 $316.00 $663.00 | 6 | |
DRB inhibits CDK9, a component of the positive transcription elongation factor b (P-TEFb), thus indirectly affecting transcription initiation and elongation processes that TAF II p150 is involved in. | ||||||
Flavopiridol Hydrochloride | 131740-09-5 | sc-207687 | 10 mg | $317.00 | ||
Flavopiridol inhibits cyclin-dependent kinases (CDKs), including CDK9, which is part of P-TEFb. This inhibition can reduce transcription elongation, thereby indirectly influencing TAF II p150's role in transcription initiation. | ||||||
Betulinic Acid | 472-15-1 | sc-200132 sc-200132A | 25 mg 100 mg | $117.00 $344.00 | 3 | |
Betulinic acid can disrupt the transcription of certain genes by modulating the activity of transcription factors and could, therefore, have an indirect effect on TAF II p150's function in the transcription process. | ||||||
MG-132 [Z-Leu- Leu-Leu-CHO] | 133407-82-6 | sc-201270 sc-201270A sc-201270B | 5 mg 25 mg 100 mg | $60.00 $265.00 $1000.00 | 163 | |
MG-132 is a proteasome inhibitor that can indirectly affect TAF II p150 by stabilizing regulatory proteins involved in transcription, thereby modulating the transcription process that TAF II p150 is a part of. | ||||||
Leptomycin B | 87081-35-4 | sc-358688 sc-358688A sc-358688B | 50 µg 500 µg 2.5 mg | $107.00 $416.00 $1248.00 | 35 | |
Leptomycin B inhibits nuclear export by binding to exportin 1. This can result in altered nuclear concentrations of transcriptional regulators, thereby indirectly affecting the function of TAF II p150 in the nucleus. | ||||||
Trichostatin A | 58880-19-6 | sc-3511 sc-3511A sc-3511B sc-3511C sc-3511D | 1 mg 5 mg 10 mg 25 mg 50 mg | $152.00 $479.00 $632.00 $1223.00 $2132.00 | 33 | |
TSA is a histone deacetylase inhibitor that can alter chromatin structure and thereby modulate transcription factor access to DNA, potentially influencing TAF II p150's role in the transcription initiation complex. | ||||||
(±)-JQ1 | 1268524-69-1 | sc-472932 sc-472932A | 5 mg 25 mg | $231.00 $863.00 | 1 | |
JQ1 is a small molecule that inhibits BET bromodomains, potentially altering the activity of transcription factors and indirectly influencing the function of TAF II p150 in the transcription initiation complex. | ||||||
C646 | 328968-36-1 | sc-364452 sc-364452A | 10 mg 50 mg | $265.00 $944.00 | 5 | |
C646 is a selective inhibitor of histone acetyltransferase p300, which can impact gene expression and potentially affect TAF II p150's role in transcription regulation by altering chromatin acetylation. | ||||||
Rocaglamide | 84573-16-0 | sc-203241 sc-203241A sc-203241B sc-203241C sc-203241D | 100 µg 1 mg 5 mg 10 mg 25 mg | $275.00 $474.00 $1639.00 $2497.00 $5344.00 | 4 | |
Rocaglamide is a natural product that can inhibit translation initiation. While not directly affecting transcription, it can influence protein levels of transcription factors and co-activators that interact with TAF II p150. | ||||||