TAF I p110_TAF I p95 Inhibitors
TAF I p110 and TAF I p95 inhibitors constitute a specialized chemical class of molecules designed to target specific proteins involved in transcriptional regulation and chromatin remodeling within the cell. TAF I p110 and TAF I p95 are subunits of the TFIID complex, which is an integral part of the transcription machinery responsible for initiating the transcription of protein-coding genes. These subunits play crucial roles in regulating gene expression by assisting in the assembly of the pre-initiation complex at gene promoters. TAF I p110, also known as TAF6, and TAF I p95, also known as TAF9, contribute to the stability and function of the TFIID complex, facilitating the recruitment of RNA polymerase II and other transcription factors to the promoter region of genes.
Inhibitors targeting TAF I p110 and TAF I p95 are designed to interfere with the interactions between these subunits and other components of the transcriptional machinery, disrupting the proper assembly and function of the TFIID complex. By modulating the activity of these key transcriptional regulators, these inhibitors can impact gene expression patterns and cellular responses to various environmental signals. Research on TAF I p110 and TAF I p95 inhibitors is primarily focused on advancing our understanding of the intricate mechanisms underlying gene transcription and chromatin dynamics within the nucleus, with implications for a wide range of biological processes.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Camptothecin | 7689-03-4 | sc-200871 sc-200871A sc-200871B | 50 mg 250 mg 100 mg | $58.00 $186.00 $94.00 | 21 | |
Inhibits DNA topoisomerase I, leading to DNA damage and potential downregulation of transcription processes. | ||||||
Etoposide (VP-16) | 33419-42-0 | sc-3512B sc-3512 sc-3512A | 10 mg 100 mg 500 mg | $51.00 $231.00 $523.00 | 63 | |
Targets DNA topoisomerase II, causing DNA strand breaks which can inhibit transcription and gene expression. | ||||||
Rocaglamide | 84573-16-0 | sc-203241 sc-203241A sc-203241B sc-203241C sc-203241D | 100 µg 1 mg 5 mg 10 mg 25 mg | $275.00 $474.00 $1639.00 $2497.00 $5344.00 | 4 | |
May inhibit translation and indirectly affect the stability of transcription factors, reducing gene expression. | ||||||
Cordycepin | 73-03-0 | sc-203902 | 10 mg | $101.00 | 5 | |
Adenosine analog that can terminate RNA chain elongation, possibly affecting transcription efficacy. | ||||||
Betulinic Acid | 472-15-1 | sc-200132 sc-200132A | 25 mg 100 mg | $117.00 $344.00 | 3 | |
May modulate transcription factors and signaling pathways, resulting in altered gene expression. | ||||||
Cantharidin | 56-25-7 | sc-201321 sc-201321A | 25 mg 100 mg | $89.00 $279.00 | 6 | |
Inhibits protein phosphatases PP1 and PP2A, potentially affecting transcription factor dephosphorylation and activity. | ||||||
Chloroquine | 54-05-7 | sc-507304 | 250 mg | $69.00 | 2 | |
Known to intercalate into DNA and RNA, which can interfere with transcription and RNA processing. | ||||||
Ellipticine | 519-23-3 | sc-200878 sc-200878A | 10 mg 50 mg | $145.00 $569.00 | 4 | |
Acts as an intercalating agent and can inhibit DNA topoisomerase II, affecting transcription. | ||||||
Mitoxantrone | 65271-80-9 | sc-207888 | 100 mg | $285.00 | 8 | |
Intercalates into DNA and inhibits topoisomerase II, leading to disruption of DNA replication and transcription. | ||||||
Aclacinomycin A | 57576-44-0 | sc-200160 | 5 mg | $132.00 | 10 | |
Binds to DNA and interferes with the synthesis of RNA, potentially affecting gene expression. | ||||||