TAB182 Activators
Tankyrase 1 binding protein 1 (TNKS1BP1), also known as TAB182, is a protein that interacts with tankyrase 1, a poly(ADP-ribose) polymerase (PARP) enzyme. Tankyrases are involved in a variety of cellular processes, including regulation of telomere length, Wnt/β-catenin signaling, and vesicle trafficking. TNKS1BP1, as a binding partner, is implicated in the regulation and stabilization of tankyrase 1, influencing its activity and the downstream effects on cellular functions.
The interaction between TNKS1BP1 and tankyrase 1 is particularly important in the context of telomere maintenance. Tankyrase 1 has been shown to poly(ADP-ribosyl)ate TRF1, a component of the shelterin complex that protects telomeres, leading to its release from telomeres and thus affecting telomere length regulation. TNKS1BP1, by binding to tankyrase 1, may modulate this process and impact genomic stability.Furthermore, TNKS1BP1 has been found to associate with other proteins involved in DNA damage response and repair, suggesting a broader role in maintaining genomic integrity. The protein may also participate in signaling pathways that govern cell proliferation and survival, which are critical in development and cancer.
SEE ALSO...
Items 1 to 10 of 12 total
Display:
| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Forskolin | 66575-29-9 | sc-3562 sc-3562A sc-3562B sc-3562C sc-3562D | 5 mg 50 mg 1 g 2 g 5 g | $78.00 $153.00 $740.00 $1413.00 $2091.00 | 73 | |
Forskolin can increase cAMP levels, potentially affecting TNKS1BP1 expression through cAMP-dependent transcription factors. | ||||||
(−)-Epigallocatechin Gallate | 989-51-5 | sc-200802 sc-200802A sc-200802B sc-200802C sc-200802D sc-200802E | 10 mg 50 mg 100 mg 500 mg 1 g 10 g | $43.00 $73.00 $126.00 $243.00 $530.00 $1259.00 | 11 | |
EGCG may modulate signaling pathways that influence TNKS1BP1 expression due to its broad effects on cell signaling. | ||||||
PMA | 16561-29-8 | sc-3576 sc-3576A sc-3576B sc-3576C sc-3576D | 1 mg 5 mg 10 mg 25 mg 100 mg | $41.00 $132.00 $214.00 $500.00 $948.00 | 119 | |
PMA, as a PKC activator, could potentially upregulate TNKS1BP1 expression by affecting PKC-dependent signaling pathways. | ||||||
Lithium | 7439-93-2 | sc-252954 | 50 g | $214.00 | ||
Lithium influences GSK-3β signaling and might indirectly affect TNKS1BP1 expression through Wnt/β-catenin signaling pathways. | ||||||
5-Aza-2′-Deoxycytidine | 2353-33-5 | sc-202424 sc-202424A sc-202424B | 25 mg 100 mg 250 mg | $218.00 $322.00 $426.00 | 7 | |
Decitabine may upregulate TNKS1BP1 expression by reducing methylation levels of the gene's promoter region. | ||||||
Cholecalciferol | 67-97-0 | sc-205630 sc-205630A sc-205630B | 1 g 5 g 10 g | $71.00 $163.00 $296.00 | 2 | |
Vitamin D3, through its receptor, could modulate immune responses and potentially affect TNKS1BP1 expression. | ||||||
Curcumin | 458-37-7 | sc-200509 sc-200509A sc-200509B sc-200509C sc-200509D sc-200509F sc-200509E | 1 g 5 g 25 g 100 g 250 g 1 kg 2.5 kg | $37.00 $69.00 $109.00 $218.00 $239.00 $879.00 $1968.00 | 47 | |
Curcumin's immunomodulatory effects might extend to regulating TNKS1BP1 expression in immune cells. | ||||||
Resveratrol | 501-36-0 | sc-200808 sc-200808A sc-200808B | 100 mg 500 mg 5 g | $80.00 $220.00 $460.00 | 64 | |
Resveratrol may influence TNKS1BP1 expression through its interaction with multiple signaling pathways. | ||||||
D,L-Sulforaphane | 4478-93-7 | sc-207495A sc-207495B sc-207495C sc-207495 sc-207495E sc-207495D | 5 mg 10 mg 25 mg 1 g 10 g 250 mg | $153.00 $292.00 $489.00 $1325.00 $8465.00 $933.00 | 22 | |
Sulforaphane activates the Nrf2 pathway, which could lead to changes in TNKS1BP1 expression as part of cellular defense mechanisms. | ||||||
Aspirin | 50-78-2 | sc-202471 sc-202471A | 5 g 50 g | $20.00 $42.00 | 4 | |
Aspirin affects inflammatory pathways and may modulate TNKS1BP1 expression through its COX-inhibiting action. | ||||||