T2R3 Activators
T2R3 activators are comprised of a diverse group of compounds, most of which are characterized by their bitter taste. These activators, such as denatonium and quinine, typically exert their effects by binding directly to the extracellular domain of T2R3, inducing a conformational change that activates the receptor. This activation triggers a cascade of intracellular signaling events, often involving the activation of G protein-coupled receptor pathways and the subsequent release of calcium from intracellular stores. The increased intracellular calcium concentration signals the perception of bitterness, which is the primary function of T2R3.
The functional mechanisms of T2R3 activators are further exemplified by compounds like colchicine and parthenolide. While these substances may not be traditionally associated with taste, their ability to bind to T2R3 and alter receptor conformation enhances the receptor's activity. Activation of T2R3 by these compounds results in the modulation of downstream signaling pathways, such as the phospholipase C pathway, which ultimately amplifies the cellular response to bitter compounds. Additionally, the activation of T2R3 by chemicals like hop extract and aloin illustrates the receptor's role in detecting a wide range of bitter molecules, highlighting the specificity and versatility of T2R
| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Denatonium benzoate | 3734-33-6 | sc-234525 sc-234525A sc-234525B sc-234525C sc-234525D | 1 g 5 g 25 g 100 g 250 g | $32.00 $47.00 $141.00 $473.00 $921.00 | ||
Denatonium is known as one of the most bitter substances. It binds directly to T2R3, causing a conformational change that activates the receptor, leading to an increase in intracellular calcium levels and subsequent cellular responses to bitter stimuli. | ||||||
Quinine | 130-95-0 | sc-212616 sc-212616A sc-212616B sc-212616C sc-212616D | 1 g 5 g 10 g 25 g 50 g | $79.00 $104.00 $166.00 $354.00 $572.00 | 1 | |
Quinine is a natural compound known for its bitter taste. It activates T2R3 by binding to its extracellular domain, triggering the G protein-coupled receptor mechanism, and resulting in the activation of the phospholipase C pathway, enhancing T2R3's receptor activity. | ||||||
Colchicine | 64-86-8 | sc-203005 sc-203005A sc-203005B sc-203005C sc-203005D sc-203005E | 1 g 5 g 50 g 100 g 500 g 1 kg | $100.00 $321.00 $2289.00 $4484.00 $18207.00 $34749.00 | 3 | |
Colchicine, while known for its medicinal properties, also has a bitter taste and can activate T2R3 by allosteric modulation, enhancing its sensitivity to other bitter compounds and increasing the downstream signaling events. | ||||||
Parthenolide | 20554-84-1 | sc-3523 sc-3523A | 50 mg 250 mg | $81.00 $306.00 | 32 | |
Parthenolide has a bitter taste and can bind to T2R3, leading to its activation. This enhances the release of calcium from the endoplasmic reticulum, amplifying the signaling pathways in which T2R3 is involved. | ||||||
D-(−)-Salicin | 138-52-3 | sc-218004 | 5 g | $59.00 | ||
Salicin is a bitter-tasting compound that activates T2R3, leading to the enhancement of the G protein-coupled receptor signaling cascade specific to the perception of bitterness. | ||||||
Picrotoxin | 124-87-8 | sc-202765 sc-202765A sc-202765B | 1 g 5 g 25 g | $67.00 $286.00 $1326.00 | 11 | |
Picrotoxin is a bitter compound that can enhance T2R3 activity by directly interacting with the receptor and promoting calcium signaling pathways that are involved in the perception of bitterness. | ||||||
Aloin | 1415-73-2 | sc-214525 sc-214525A | 25 mg 100 mg | $159.00 $271.00 | 1 | |
Aloin is a bitter-tasting compound that activates T2R3 by binding to it, leading to an enhancement of the signaling mechanisms involved in the bitter taste response. | ||||||