T Cell Marker Inhibitors
T Cell Marker Inhibitors represent a class of chemical compounds designed to target and inhibit specific markers or molecules associated with T cells, a crucial component of the immune system. T cells play a central role in the body's defense against pathogens and cancer, and they are involved in immune surveillance, regulation, and response. These inhibitors are developed to influence the behavior or activity of T cells by targeting specific surface markers or signaling molecules.
The development of T Cell Marker Inhibitors is a multidisciplinary endeavor that encompasses various fields of science, including immunology, molecular biology, and medicinal chemistry. Researchers identify specific molecules or surface markers on T cells that are of interest for modulation. These markers may include proteins, receptors, or signaling molecules involved in T cell activation, differentiation, or migration. Once a target marker is identified, synthetic chemists design and synthesize chemical compounds capable of selectively binding to or interacting with the marker. This binding or interaction can modulate the behavior of T cells in experimental settings, providing valuable insights into immune responses and cellular functions. Advanced techniques like high-throughput screening, structural biology, and molecular modeling are employed to discover and optimize T Cell Marker Inhibitors. Additionally, researchers aim to understand the precise mechanisms through which these inhibitors affect T cell biology, shedding light on the complex and dynamic nature of the immune system. The development of T Cell Marker Inhibitors contributes to our understanding of immune responses and can offer tools for exploring the intricacies of T cell biology in various research contexts.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Rapamycin | 53123-88-9 | sc-3504 sc-3504A sc-3504B | 1 mg 5 mg 25 mg | $63.00 $158.00 $326.00 | 233 | |
Rapamycin binds to mTOR, a crucial kinase for T cell proliferation. By inhibiting mTOR, rapamycin may decrease the expression of T cell markers that are associated with T cell activation and proliferation. | ||||||
Ascomycin | 104987-12-4 | sc-207303B sc-207303 sc-207303A | 1 mg 5 mg 25 mg | $37.00 $176.00 $322.00 | ||
Ascomycin is an immunosuppressant that interacts with the immunophilins and calcineurin like cyclosporin, potentially modulating T cell activation and reducing the expression of certain T cell markers. | ||||||
Azathioprine | 446-86-6 | sc-210853D sc-210853 sc-210853A sc-210853B sc-210853C | 500 mg 1 g 2 g 5 g 10 g | $203.00 $176.00 $349.00 $505.00 $704.00 | 1 | |
Azathioprine is a compound that is metabolized into 6-mercaptopurine, which may inhibit nucleotide synthesis. This could lead to reduced proliferation of T cells and a decrease in the expression of T cell markers. | ||||||
6-Thioguanine | 154-42-7 | sc-205587 sc-205587A | 250 mg 500 mg | $42.00 $54.00 | 3 | |
6-Thioguanine is incorporated into DNA and RNA, disrupting nucleic acid function and potentially hindering T cell proliferation and the expression of T cell markers. | ||||||
Methotrexate | 59-05-2 | sc-3507 sc-3507A | 100 mg 500 mg | $94.00 $213.00 | 33 | |
Methotrexate is a dihydrofolate reductase inhibitor that can impact DNA synthesis and cell proliferation. It may lead to decreased T cell proliferation and subsequently lower expression of T cell markers. | ||||||
Leflunomide | 75706-12-6 | sc-202209 sc-202209A | 10 mg 50 mg | $20.00 $83.00 | 5 | |
Leflunomide inhibits dihydroorotate dehydrogenase, affecting pyrimidine synthesis, which is necessary for lymphocyte proliferation. This could result in reduced expression of T cell markers. | ||||||
Mycophenolate mofetil | 128794-94-5 | sc-200971 sc-200971A | 20 mg 100 mg | $37.00 $109.00 | 1 | |
Mycophenolate mofetil inhibits inosine monophosphate dehydrogenase, leading to reduced proliferation of T cells and potentially lowering the expression of T cell markers. | ||||||
Hydroxyurea | 127-07-1 | sc-29061 sc-29061A | 5 g 25 g | $78.00 $260.00 | 18 | |
Hydroxyurea is used to inhibit ribonucleotide reductase, which could lead to a decreased T cell proliferation and, as a result, may lower the expression of T cell markers. | ||||||
Fludarabine | 21679-14-1 | sc-204755 sc-204755A | 5 mg 25 mg | $58.00 $204.00 | 15 | |
Fludarabine is a nucleotide analog that interferes with DNA synthesis, which might reduce T cell proliferation and the expression of T cell markers. | ||||||
2-Deoxy-D-glucose | 154-17-6 | sc-202010 sc-202010A | 1 g 5 g | $70.00 $215.00 | 26 | |
2-DG is a glucose analog that inhibits glycolysis. T cells rely on glycolysis for energy during activation, and inhibition of this pathway by 2-DG could reduce T cell activation and therefore decrease the expression of T cell markers. | ||||||