Tβ-10 Inhibitors
Chemical inhibitors of Tβ-10 interfere with the protein's function by targeting the dynamic equilibrium of microtubules, which are essential for various cellular processes. Colchicine, for instance, binds to tubulin, thereby disrupting the polymerization of microtubules and indirectly inhibiting the stabilization role of Tβ-10. Similarly, Vinblastine and Vincristine inhibit microtubule assembly, compromising Tβ-10's ability to interact with and maintain the structural integrity of microtubules. Podophyllotoxin and Nocodazole both bind to tubulin, with the former inhibiting polymerization and the latter leading to depolymerization, actions that result in the disruption of microtubule assembly and subsequent inhibition of Tβ-10's associated functions. These chemicals collectively demonstrate a variety of mechanisms by which the normal functioning of Tβ-10 can be inhibited, all of which involve the disruption of microtubule dynamics upon which Tβ-10 acts.
Further illustrating the diversity of mechanisms, Paclitaxel (Taxol) and Eribulin exhibit their effects by stabilizing microtubules, but this stabilization is so robust that it effectively 'freezes' the microtubules, preventing Tβ-10 from performing its normal role in microtubule growth and turnover. Griseofulvin, Albendazole, Mebendazole, and Thiabendazole all target the polymerization process of microtubules by binding to tubulin, particularly β-tubulin, thereby inhibiting the formation and maintenance of microtubules necessary for Tβ-10 function. Vinorelbine, like Vinblastine and Vincristine, impedes microtubule assembly, further contributing to the inhibition of Tβ-10.
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Items 1 to 10 of 11 total
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Colchicine | 64-86-8 | sc-203005 sc-203005A sc-203005B sc-203005C sc-203005D sc-203005E | 1 g 5 g 50 g 100 g 500 g 1 kg | $98.00 $315.00 $2244.00 $4396.00 $17850.00 $34068.00 | 3 | |
Colchicine binds to tubulin, disrupting microtubule dynamics, which is essential for cell division and intracellular transport. As Tβ-10 is involved in the stabilization of the cytoskeleton and microtubules, colchicine's action can lead to the functional inhibition of Tβ-10 by destabilizing structures that Tβ-10 is known to associate with and regulate. | ||||||
Taxol | 33069-62-4 | sc-201439D sc-201439 sc-201439A sc-201439E sc-201439B sc-201439C | 1 mg 5 mg 25 mg 100 mg 250 mg 1 g | $40.00 $73.00 $217.00 $242.00 $724.00 $1196.00 | 39 | |
Paclitaxel stabilizes microtubules and prevents their disassembly, which can paradoxically inhibit the functions of Tβ-10 that are associated with microtubule dynamics. The stabilization effect of paclitaxel can effectively 'freeze' the microtubules, preventing Tβ-10 from performing its role in microtubule growth and turnover. | ||||||
Vinblastine | 865-21-4 | sc-491749 sc-491749A sc-491749B sc-491749C sc-491749D | 10 mg 50 mg 100 mg 500 mg 1 g | $100.00 $230.00 $450.00 $1715.00 $2900.00 | 4 | |
Vinblastine binds to tubulin, inhibiting microtubule assembly. By preventing microtubule formation, vinblastine indirectly inhibits Tβ-10 function, as Tβ-10's role is contingent upon the proper formation and maintenance of microtubules. | ||||||
Podophyllotoxin | 518-28-5 | sc-204853 | 100 mg | $82.00 | 1 | |
Podophyllotoxin binds to tubulin and inhibits its polymerization. This action disrupts microtubule assembly, on which Tβ-10's function relies, leading to an indirect inhibition of Tβ-10's role in cytoskeletal maintenance. | ||||||
Nocodazole | 31430-18-9 | sc-3518B sc-3518 sc-3518C sc-3518A | 5 mg 10 mg 25 mg 50 mg | $58.00 $83.00 $140.00 $242.00 | 38 | |
Nocodazole disrupts microtubule polymerization and leads to microtubule depolymerization, which can inhibit the function of Tβ-10 by preventing the formation of the microtubule structures that Tβ-10 is meant to stabilize and regulate. | ||||||
Eribulin | 253128-41-5 | sc-507547 | 5 mg | $865.00 | ||
Eribulin binds microtubule ends and inhibits their growth, which directly impacts Tβ-10's function by preventing the microtubule dynamics that Tβ-10 is known to support and modulate. | ||||||
Griseofulvin | 126-07-8 | sc-202171A sc-202171 sc-202171B | 5 mg 25 mg 100 mg | $83.00 $216.00 $586.00 | 4 | |
Griseofulvin disrupts microtubule function by binding to tubulin, which can inhibit Tβ-10's ability to stabilize microtubules as it interferes with the polymerization process that is essential for Tβ-10 function. | ||||||
Albendazole | 54965-21-8 | sc-210771 | 100 mg | $209.00 | 1 | |
Albendazole causes the loss of microtubule integrity by binding to β-tubulin, which is expected to inhibit Tβ-10's activity by disrupting the microtubule networks that Tβ-10 is involved in stabilizing. | ||||||
Mebendazole | 31431-39-7 | sc-204798 sc-204798A | 5 g 25 g | $45.00 $87.00 | 2 | |
Mebendazole binds to β-tubulin and inhibits its polymerization, which would inhibit Tβ-10's function by preventing the formation of microtubules, structures that are essential for Tβ-10's role in the cell. | ||||||
Thiabendazole | 148-79-8 | sc-204913 sc-204913A sc-204913B sc-204913C sc-204913D | 10 g 100 g 250 g 500 g 1 kg | $31.00 $82.00 $179.00 $306.00 $561.00 | 5 | |
Thiabendazole inhibits the polymerization of microtubules by binding to β-tubulin, which would lead to functional inhibition of Tβ-10 by disrupting the cytoskeletal structures it stabilizes and regulates. | ||||||