Synapsin Ia Activators
Synapsin Ia Activators encompass a range of chemical compounds that indirectly enhance the functional activity of Synapsin Ia, predominantly through pathways involving cAMP and protein kinase A (PKA). Compounds such as Forskolin, Isoproterenol, Epinephrine, and Prostaglandin E2 (PGE2) activate adenylate cyclase, leading to elevated cAMP levels in neuronal cells. This increase in cAMP activates PKA, which plays a crucial role in phosphorylating Synapsin Ia. Phosphorylation of Synapsin Ia by PKA results in its detachment from synaptic vesicles, thereby facilitating neurotransmitter release. Similarly, compounds like Rolipram, IBMX, and Vinpocetine, by inhibiting phosphodiesterases, prevent cAMP degradation, thus indirectly promoting PKA-mediated phosphorylation of Synapsin Ia. This biochemical cascade enhances Synapsin Ia's role in modulating neurotransmitter release, critical for efficient synaptic transmission.
Further refining the modulation of Synapsin Ia's activity, chemicals like 8-Bromo-cAMP and Dibutyryl-cAMP, cAMP analogs, directly activate PKA, leading to the phosphorylation of Synapsin Ia. This action mimics the natural upstream signaling events, reinforcing the role of Synapsin Ia in neurotransmitter release. On the other hand, K-252a and H-89, by inhibiting various kinases, including some PKA targets, create a favorable environment for the selective phosphorylation of Synapsin Ia by PKA. The strategic inhibition of competing kinases ensures that PKA-mediated phosphorylation of Synapsin Ia is enhanced, further promoting the mobilization of synaptic vesicles. Collectively, these Synapsin Ia Activators, through their targeted influence on cAMP and PKA pathways, facilitate the enhancement of Synapsin Ia-mediated functions, crucial for the dynamic regulation of synaptic neurotransmitter release.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Forskolin | 66575-29-9 | sc-3562 sc-3562A sc-3562B sc-3562C sc-3562D | 5 mg 50 mg 1 g 2 g 5 g | $78.00 $153.00 $740.00 $1413.00 $2091.00 | 73 | |
Forskolin activates adenylate cyclase, increasing cAMP levels in neurons. Elevated cAMP activates PKA, which can phosphorylate Synapsin Ia. This phosphorylation detaches Synapsin Ia from synaptic vesicles, enhancing neurotransmitter release. | ||||||
Rolipram | 61413-54-5 | sc-3563 sc-3563A | 5 mg 50 mg | $77.00 $216.00 | 18 | |
Rolipram inhibits phosphodiesterase 4, preventing cAMP degradation. This raises intracellular cAMP levels, indirectly activating PKA, which phosphorylates Synapsin Ia, facilitating synaptic vesicle mobilization and neurotransmitter release. | ||||||
8-Bromo-cAMP | 76939-46-3 | sc-201564 sc-201564A | 10 mg 50 mg | $126.00 $328.00 | 30 | |
8-Bromo-cAMP, a cAMP analog, mimics cAMP and activates PKA. Activated PKA phosphorylates Synapsin Ia, promoting its dissociation from synaptic vesicles and enhancing neurotransmitter release. | ||||||
K-252a | 99533-80-9 | sc-200517 sc-200517B sc-200517A | 100 µg 500 µg 1 mg | $129.00 $214.00 $498.00 | 19 | |
K-252a is a kinase inhibitor that selectively inhibits certain protein kinases. By inhibiting competing kinases, K-252a indirectly enhances PKA-mediated phosphorylation of Synapsin Ia, facilitating neurotransmitter release. | ||||||
IBMX | 28822-58-4 | sc-201188 sc-201188B sc-201188A | 200 mg 500 mg 1 g | $260.00 $350.00 $500.00 | 34 | |
IBMX is a non-specific inhibitor of phosphodiesterases, increasing intracellular cAMP levels. This indirectly enhances PKA activity, leading to the phosphorylation of Synapsin Ia, which promotes neurotransmitter release. | ||||||
Isoproterenol Hydrochloride | 51-30-9 | sc-202188 sc-202188A | 100 mg 500 mg | $28.00 $38.00 | 5 | |
Isoproterenol, a beta-adrenergic agonist, stimulates adenylate cyclase, raising cAMP levels. Increased cAMP activates PKA, which phosphorylates Synapsin Ia, enhancing synaptic vesicle mobilization for neurotransmitter release. | ||||||
(−)-Epinephrine | 51-43-4 | sc-205674 sc-205674A sc-205674B sc-205674C sc-205674D | 1 g 5 g 10 g 100 g 1 kg | $41.00 $104.00 $201.00 $1774.00 $16500.00 | ||
Epinephrine activates adenylate cyclase via adrenergic receptors, increasing cAMP and activating PKA. PKA phosphorylates Synapsin Ia, facilitating the release of neurotransmitters at synapses. | ||||||
PGE2 | 363-24-6 | sc-201225 sc-201225C sc-201225A sc-201225B | 1 mg 5 mg 10 mg 50 mg | $57.00 $159.00 $275.00 $678.00 | 37 | |
Prostaglandin E2 (PGE2) binds to its receptors, leading to adenylate cyclase activation and increased cAMP. The resulting PKA activation phosphorylates Synapsin Ia, enhancing neurotransmitter release. | ||||||
Dibutyryl-cAMP | 16980-89-5 | sc-201567 sc-201567A sc-201567B sc-201567C | 20 mg 100 mg 500 mg 10 g | $47.00 $136.00 $492.00 $4552.00 | 74 | |
Dibutyryl-cAMP is a cAMP analog that activates PKA. This leads to the phosphorylation of Synapsin Ia, promoting the release of neurotransmitters from synaptic vesicles. | ||||||
Vinpocetine | 42971-09-5 | sc-201204 sc-201204A sc-201204B | 20 mg 100 mg 15 g | $55.00 $214.00 $2400.00 | 4 | |
Vinpocetine inhibits phosphodiesterase 1, leading to increased cAMP levels. Elevated cAMP activates PKA, which phosphorylates Synapsin Ia, enhancing synaptic vesicle mobilization and neurotransmitter release. | ||||||