SWI5 Inhibitors
Chemical inhibitors of SWI5 include a variety of compounds that disrupt different cellular processes crucial for the protein's function. Trichostatin A is a histone deacetylase inhibitor that impedes the acetylation process vital for chromatin remodeling, which is a prerequisite for the transcription of genes including those that code for regulatory proteins that interact with SWI5. By this action, Trichostatin A can lead to the functional inhibition of SWI5 by preventing the expression of these regulatory proteins. Chetomin, by disrupting the chromatin remodeling process, can inhibit the interaction between hypoxia-inducible factors and the coactivator p300/CBP, leading to reduced expression of proteins required for SWI5's proper function. The SERCA inhibitor, Cyclopiazonic Acid, alters calcium homeostasis, which can inhibit the signal transduction pathways necessary for SWI5 activation. Mitoxantrone and Camptothecin, by interfering with DNA replication and topoisomerase enzymes respectively, inhibit the transcription of genes coding for proteins that interact with SWI5, thus directly inhibiting its function.
Furthermore, Etoposide, another topoisomerase II inhibitor, can induce DNA damage and inhibit gene transcription required for SWI5 function. Rocaglamide can reduce the synthesis of essential proteins for SWI5 function by binding to the eIF4A component of the translation initiation complex, thus inhibiting translation. Rapamycin and 17-AAG (Tanespimycin) inhibit mTOR and Hsp90 chaperone activity respectively. The inhibition of mTOR by Rapamycin can regulate proteins interacting with SWI5, while the inhibition of Hsp90 by 17-AAG can prevent the proper folding of such proteins, both leading to the functional inhibition of SWI5. Geldanamycin, akin to 17-AAG, binds to Hsp90 and inhibits the maturation of regulatory proteins that interact with SWI5. Lastly, inhibitors of p38 MAP kinase, PD169316 and SB203580, inhibit the phosphorylation of proteins that are essential for the function of SWI5, thereby leading to its inhibition.
Items 1 to 10 of 12 total
Display:
| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Trichostatin A | 58880-19-6 | sc-3511 sc-3511A sc-3511B sc-3511C sc-3511D | 1 mg 5 mg 10 mg 25 mg 50 mg | $152.00 $479.00 $632.00 $1223.00 $2132.00 | 33 | |
Trichostatin A is a histone deacetylase inhibitor that can inhibit the acetylation of histones, which is necessary for chromatin remodeling and subsequent transcription of genes, including those that code for regulatory proteins that interact with SWI5, leading to its functional inhibition. | ||||||
Chetomin | 1403-36-7 | sc-202535 sc-202535A | 1 mg 5 mg | $186.00 $674.00 | 10 | |
Chetomin disrupts the chromatin remodeling process by inhibiting the interaction between hypoxia-inducible factors and the p300/CBP coactivator, which may result in decreased expression of proteins that are required for SWI5 to function properly, thereby inhibiting SWI5. | ||||||
Cyclopiazonic Acid | 18172-33-3 | sc-201510 sc-201510A | 10 mg 50 mg | $176.00 $624.00 | 3 | |
Cyclopiazonic Acid is an inhibitor of SERCA (sarco/endoplasmic reticulum Ca2+-ATPase), leading to altered calcium homeostasis. This change in calcium levels can inhibit the signal transduction pathways that are necessary for SWI5 activation. | ||||||
Mitoxantrone | 65271-80-9 | sc-207888 | 100 mg | $285.00 | 8 | |
Mitoxantrone interferes with DNA replication and repair. This interference can inhibit the transcription of genes coding for proteins that directly interact with SWI5, resulting in inhibition of its function. | ||||||
Camptothecin | 7689-03-4 | sc-200871 sc-200871A sc-200871B | 50 mg 250 mg 100 mg | $58.00 $186.00 $94.00 | 21 | |
Camptothecin inhibits DNA topoisomerase I, preventing DNA from unwinding. This can inhibit the transcription of genes coding for essential cofactors or proteins that interact with SWI5, thereby inhibiting its function. | ||||||
Etoposide (VP-16) | 33419-42-0 | sc-3512B sc-3512 sc-3512A | 10 mg 100 mg 500 mg | $51.00 $231.00 $523.00 | 63 | |
Etoposide inhibits DNA topoisomerase II, leading to DNA damage and potentially inhibiting the transcription of genes necessary for the proper function of SWI5. | ||||||
Rocaglamide | 84573-16-0 | sc-203241 sc-203241A sc-203241B sc-203241C sc-203241D | 100 µg 1 mg 5 mg 10 mg 25 mg | $275.00 $474.00 $1639.00 $2497.00 $5344.00 | 4 | |
Rocaglamide inhibits translation by binding to the eIF4A component of the translation initiation complex, potentially reducing the synthesis of proteins that are essential for the function of SWI5, leading to its inhibition. | ||||||
Rapamycin | 53123-88-9 | sc-3504 sc-3504A sc-3504B | 1 mg 5 mg 25 mg | $63.00 $158.00 $326.00 | 233 | |
Rapamycin forms a complex with FKBP12, inhibiting mTOR, which is involved in the PI3K/Akt pathway, a pathway that can regulate proteins interacting with SWI5, leading to its functional inhibition. | ||||||
17-AAG | 75747-14-7 | sc-200641 sc-200641A | 1 mg 5 mg | $67.00 $156.00 | 16 | |
17-AAG inhibits Hsp90 chaperone activity, which is crucial for the proper folding and function of many signaling proteins that are part of pathways in which SWI5 operates, thereby inhibiting SWI5 function. | ||||||
Geldanamycin | 30562-34-6 | sc-200617B sc-200617C sc-200617 sc-200617A | 100 µg 500 µg 1 mg 5 mg | $39.00 $59.00 $104.00 $206.00 | 8 | |
Geldanamycin also binds to Hsp90, inhibiting its chaperone activity, and thereby potentially inhibiting the maturation of proteins that interact with or regulate SWI5, leading to its functional inhibition. | ||||||