SUZ12 Inhibitors
SUZ12 inhibitors belong to a specific class of small molecules that have gained significant attention in the field of molecular biology and epigenetics. These compounds are designed to target the SUZ12 protein, a crucial component of the polycomb repressive complex 2 (PRC2), which plays a pivotal role in gene regulation and chromatin remodeling. SUZ12, along with other PRC2 subunits, contributes to the maintenance of gene silencing by catalyzing the trimethylation of lysine 27 on histone H3 (H3K27me3), a histone modification associated with transcriptional repression. Inhibiting SUZ12 can disrupt this epigenetic regulation, leading to alterations in gene expression patterns.
SUZ12 inhibitors are designed to specifically bind to the SUZ12 protein, thereby interfering with its function within the PRC2 complex. By doing so, these inhibitors disrupt the enzymatic activity of PRC2 and reduce the levels of H3K27me3 marks at target genes. This modulation of epigenetic marks can have wide-ranging effects on gene expression, leading to the activation of genes that are normally silenced, or the repression of genes that are typically active. Researchers have been exploring the use of SUZ12 inhibitors as valuable tools in elucidating the intricacies of gene regulation and epigenetic mechanisms. Understanding the precise molecular mechanisms by which SUZ12 inhibitors work can provide valuable insights into the fundamental processes of gene expression and chromatin remodeling, shedding light on the broader field of epigenetics.
SEE ALSO...
| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
5-Azacytidine | 320-67-2 | sc-221003 | 500 mg | $280.00 | 4 | |
This compound is a nucleoside analog of cytidine that can be incorporated into DNA and RNA. It inhibits DNA methyltransferases, potentially reducing the methylation of the SUZ12 promoter, leading to its increased expression. | ||||||
RG 108 | 48208-26-0 | sc-204235 sc-204235A | 10 mg 50 mg | $131.00 $515.00 | 2 | |
RG108 is a non-nucleoside DNA methyltransferase inhibitor. It might prevent the methylation of the SUZ12 promoter, thus potentially decreasing SUZ12 gene silencing. | ||||||
Disulfiram | 97-77-8 | sc-205654 sc-205654A | 50 g 100 g | $53.00 $89.00 | 7 | |
Disulfiram can chelate copper, forming a complex that can inhibit the proteasome. This could lead to increased degradation of transcription factors that are essential for SUZ12 expression. | ||||||
Genistein | 446-72-0 | sc-3515 sc-3515A sc-3515B sc-3515C sc-3515D sc-3515E sc-3515F | 100 mg 500 mg 1 g 5 g 10 g 25 g 100 g | $45.00 $164.00 $200.00 $402.00 $575.00 $981.00 $2031.00 | 46 | |
Genistein is an isoflavone that has been shown to act as a tyrosine kinase inhibitor. It can modulate the activity of various transcription factors and signaling pathways, which might affect SUZ12 expression. | ||||||
Retinoic Acid, all trans | 302-79-4 | sc-200898 sc-200898A sc-200898B sc-200898C | 500 mg 5 g 10 g 100 g | $66.00 $325.00 $587.00 $1018.00 | 28 | |
Retinoic acid, the active metabolite of Vitamin A, can regulate gene expression through its role as a ligand for retinoic acid receptors. This may impact the transcription of SUZ12. | ||||||
5-Aza-2′-Deoxycytidine | 2353-33-5 | sc-202424 sc-202424A sc-202424B | 25 mg 100 mg 250 mg | $218.00 $322.00 $426.00 | 7 | |
5-Aza-2′-Deoxycytidine is a nucleoside analog that inhibits DNA methyltransferases. Similar to 5-azacytidine, it can demethylate DNA and affect gene expression patterns including SUZ12. | ||||||
Histone Lysine Methyltransferase Inhibitor Inhibitor | 935693-62-2 (free base) | sc-202651 | 5 mg | $151.00 | 4 | |
This is a histone methyltransferase inhibitor that targets G9a and GLP, which may indirectly affect the methylation status of SUZ12 promoter regions. | ||||||
Parthenolide | 20554-84-1 | sc-3523 sc-3523A | 50 mg 250 mg | $81.00 $306.00 | 32 | |
Parthenolide is a sesquiterpene lactone that has been shown to inhibit the NF-κB pathway, which may downregulate SUZ12 expression as a secondary effect. | ||||||
Trichostatin A | 58880-19-6 | sc-3511 sc-3511A sc-3511B sc-3511C sc-3511D | 1 mg 5 mg 10 mg 25 mg 50 mg | $152.00 $479.00 $632.00 $1223.00 $2132.00 | 33 | |
Trichostatin A is another histone deacetylase inhibitor and could influence SUZ12 expression by changing the acetylation status of histones near its gene locus. | ||||||
Mithramycin A | 18378-89-7 | sc-200909 | 1 mg | $55.00 | 6 | |
Mithramycin A binds to G-C rich DNA sequences, which can interfere with transcription factor binding to the SUZ12 promoter, potentially decreasing its expression. | ||||||