SULT3A1 Inhibitors
SULT3A1 inhibitors are a class of chemical compounds that specifically target and inhibit the activity of the sulfotransferase enzyme SULT3A1. SULT3A1 belongs to the family of sulfotransferases, enzymes responsible for catalyzing the transfer of a sulfate group from the universal sulfate donor 3'-phosphoadenosine-5'-phosphosulfate (PAPS) to various substrates. These substrates can include hormones, neurotransmitters, drugs, and xenobiotics. The sulfation process is a crucial biochemical modification that enhances the water solubility of these molecules, facilitating their metabolism, excretion, or regulation within the body. Inhibition of SULT3A1 blocks the enzyme's ability to perform this modification, affecting the bioavailability, activity, or elimination of its target molecules. As SULT3A1 is involved in the metabolism of specific molecules, its inhibition may significantly impact various physiological pathways related to detoxification and molecular regulation.
The mechanism of SULT3A1 inhibitors generally involves direct interaction with the enzyme's active site, where the inhibitor competes with PAPS or the substrate, preventing the sulfation reaction. Some inhibitors may bind to allosteric sites, inducing conformational changes that reduce the enzyme's catalytic efficiency. By inhibiting SULT3A1, these compounds interfere with the enzyme's role in maintaining molecular homeostasis, disrupting the normal metabolic pathways of sulfated molecules. This can lead to an accumulation of unsulfated substrates, altering their functional roles in processes like signal transduction, hormone regulation, and detoxification. Research into SULT3A1 inhibitors provides insights into the regulatory mechanisms of sulfation and the enzyme's specific contribution to various biochemical pathways, highlighting the complexity of sulfotransferase-mediated metabolism.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Piperine | 94-62-2 | sc-205809 sc-205809A | 5 g 25 g | $36.00 $143.00 | 3 | |
Piperine may inhibit SULT3A1 expression by potentially acting as an antagonist of the pregnane X receptor (PXR), a nuclear receptor that regulates the expression of various enzymes involved in drug metabolism, including sulfotransferases. Inhibition of PXR could lead to downregulation of SULT3A1 expression, as it is a target gene of PXR. | ||||||
Quercetin | 117-39-5 | sc-206089 sc-206089A sc-206089E sc-206089C sc-206089D sc-206089B | 100 mg 500 mg 100 g 250 g 1 kg 25 g | $11.00 $17.00 $108.00 $245.00 $918.00 $49.00 | 33 | |
Quercetin may inhibit SULT3A1 expression by potentially acting as an antagonist of the pregnane X receptor (PXR), a nuclear receptor that regulates the expression of various enzymes involved in drug metabolism, including sulfotransferases. Inhibition of PXR could lead to downregulation of SULT3A1 expression, as it is a target gene of PXR. | ||||||
Rifampicin | 13292-46-1 | sc-200910 sc-200910A sc-200910B sc-200910C | 1 g 5 g 100 g 250 g | $95.00 $322.00 $663.00 $1438.00 | 6 | |
Rifampicin may inhibit SULT3A1 expression by acting as an agonist of the pregnane X receptor (PXR). PXR activation could lead to the upregulation of various drug-metabolizing enzymes, including sulfotransferases. However, chronic or excessive activation of PXR by rifampicin might lead to the downregulation of SULT3A1 through a negative feedback mechanism or other regulatory pathways. | ||||||
Resveratrol | 501-36-0 | sc-200808 sc-200808A sc-200808B | 100 mg 500 mg 5 g | $60.00 $185.00 $365.00 | 64 | |
Resveratrol may inhibit SULT3A1 expression by potentially acting as an antagonist of the pregnane X receptor (PXR), a nuclear receptor that regulates the expression of various enzymes involved in drug metabolism, including sulfotransferases. Inhibition of PXR could lead to downregulation of SULT3A1 expression, as it is a target gene of PXR. | ||||||
Glabridin | 59870-68-7 | sc-397145 sc-397145A | 5 mg 25 mg | $130.00 $520.00 | ||
Glabridin may inhibit SULT3A1 expression by potentially acting as an antagonist of the pregnane X receptor (PXR), a nuclear receptor that regulates the expression of various enzymes involved in drug metabolism, including sulfotransferases. Inhibition of PXR could lead to downregulation of SULT3A1 expression, as it is a target gene of PXR. | ||||||
4-Methylumbelliferone | 90-33-5 | sc-206910 sc-206910A sc-206910B sc-206910C sc-206910D | 25 g 100 g 250 g 1 kg 2.5 kg | $34.00 $55.00 $138.00 $423.00 $954.00 | 2 | |
4-Methylumbelliferone may inhibit SULT3A1 expression by potentially altering the expression and activity of various nuclear receptors and transcription factors involved in regulating the expression of sulfotransferases, including pregnane X receptor (PXR) and aryl hydrocarbon receptor (AhR), leading to downregulation of SULT3A1 expression. | ||||||
Indole-3-carbinol | 700-06-1 | sc-202662 sc-202662A sc-202662B sc-202662C sc-202662D | 1 g 5 g 100 g 250 g 1 kg | $38.00 $60.00 $143.00 $306.00 $1012.00 | 5 | |
Indole-3-carbinol may inhibit SULT3A1 expression by acting as an antagonist of the aryl hydrocarbon receptor (AhR), a transcription factor involved in the regulation of phase I and phase II drug-metabolizing enzymes. Inhibition of AhR activity could lead to the downregulation of SULT3A1 expression, as sulfotransferases are among the targets of AhR-mediated gene regulation. | ||||||