STAC Inhibitors
STAC inhibitors are a class of chemical compounds that specifically target the STAC (Src homology three [SH3] and cysteine-rich domain-containing) proteins, which are involved in the regulation of ion channel activity, particularly in voltage-gated calcium channels. STAC proteins play a critical role in the modulation of excitation-contraction coupling, especially in muscle cells, by influencing the interaction between voltage-gated calcium channels and the ryanodine receptor, which controls calcium release from the sarcoplasmic reticulum. STAC proteins help stabilize this interaction, ensuring efficient calcium flow that is essential for muscle contraction and other cellular processes that depend on calcium signaling. By inhibiting STAC proteins, these compounds disrupt the normal regulation of calcium channels and affect calcium homeostasis within the cell.
The mechanism of action for STAC inhibitors generally involves binding to the SH3 or cysteine-rich domains of the STAC proteins, preventing them from interacting with voltage-gated calcium channels or other associated proteins. This inhibition interferes with the normal functioning of calcium signaling pathways, leading to alterations in calcium influx and release. As calcium is a key second messenger involved in a wide range of cellular functions, from muscle contraction to neurotransmitter release, inhibiting STAC proteins can have profound effects on cellular communication and signaling. Researchers use STAC inhibitors to study the detailed roles of these proteins in regulating calcium dynamics and to explore how disruptions in STAC-mediated signaling affect muscle function, excitation-contraction coupling, and broader calcium-dependent processes within the cell.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
PP 2 | 172889-27-9 | sc-202769 sc-202769A | 1 mg 5 mg | $94.00 $227.00 | 30 | |
Src family kinase inhibitor. STAC, with an SH3 domain, might interact with proteins in the Src pathway, and PP2 can inhibit this pathway. | ||||||
Dasatinib | 302962-49-8 | sc-358114 sc-358114A | 25 mg 1 g | $70.00 $145.00 | 51 | |
Inhibitor of Src family kinases. It can hinder the potential signaling processes STAC might participate in via its SH3 domain. | ||||||
LY 294002 | 154447-36-6 | sc-201426 sc-201426A | 5 mg 25 mg | $123.00 $400.00 | 148 | |
PI3K inhibitor. Given the SH3 domain's potential involvement in PI3K pathway signaling, LY294002 can suppress this pathway and indirectly affect STAC functionality. | ||||||
Wortmannin | 19545-26-7 | sc-3505 sc-3505A sc-3505B | 1 mg 5 mg 20 mg | $67.00 $223.00 $425.00 | 97 | |
Another PI3K inhibitor. Similarly, by inhibiting the PI3K pathway, it can potentially modulate the signaling processes where STAC plays a role. | ||||||
PD 98059 | 167869-21-8 | sc-3532 sc-3532A | 1 mg 5 mg | $40.00 $92.00 | 212 | |
MEK inhibitor that suppresses the ERK/MAPK pathway. If STAC is involved in this pathway due to its SH3 domain, PD98059 can indirectly modulate its function. | ||||||
SP600125 | 129-56-6 | sc-200635 sc-200635A | 10 mg 50 mg | $40.00 $150.00 | 257 | |
JNK inhibitor. If STAC is found to be involved in JNK-mediated signaling processes, SP600125 can inhibit these pathways, potentially influencing STAC's function. | ||||||
SB 203580 | 152121-47-6 | sc-3533 sc-3533A | 1 mg 5 mg | $90.00 $349.00 | 284 | |
p38 MAPK inhibitor. By suppressing the p38 MAPK pathway, it may modulate any potential involvement of STAC in this signaling route. | ||||||
Rapamycin | 53123-88-9 | sc-3504 sc-3504A sc-3504B | 1 mg 5 mg 25 mg | $63.00 $158.00 $326.00 | 233 | |
mTOR inhibitor. If STAC plays a role in mTOR signaling processes, Rapamycin can suppress this pathway, potentially affecting STAC's activity. | ||||||
Akt Inhibitor VIII, Isozyme-Selective, Akti-1/2 | 612847-09-3 | sc-202048 sc-202048A | 1 mg 5 mg | $208.00 $270.00 | 29 | |
AKT inhibitor. Given the SH3 domain's potential involvement in AKT pathway signaling, Akti-1/2 can potentially modulate the role STAC plays in these processes. | ||||||
Y-27632, free base | 146986-50-7 | sc-3536 sc-3536A | 5 mg 50 mg | $186.00 $707.00 | 88 | |
ROCK inhibitor. If STAC participates in Rho-associated signaling pathways, Y-27632 can suppress these pathways, indirectly affecting STAC's function. | ||||||