St3Gal-II Activators
St3Gal-II Activators are a diverse array of chemical compounds that work through various biochemical pathways to enhance the glycosylation activity of St3Gal-II. Forskolin increases intracellular cAMP levels, activating PKA, which can phosphorylate proteins within the glycosylation pathway, potentially increasing the functional activity of St3Gal-II. The cAMP analog 8-Bromoadenosine 3',5'-cyclic monophosphate further reinforces this route by providing a stable cAMP analog that activates PKA, supporting the enhanced activity of St3Gal-II in glycoprotein synthesis. MnCl2 acts as a crucial cofactor, optimizing the catalytic efficiency of St3Gal-II. Additionally, the presence of UDP-Galactose directly supplies the necessary substrate for the sialyltransferase activity of St3Gal-II.
The GTP analog GppNHp, by activating GTP-binding proteins, may enhance signaling pathways that indirectly increase St3Gal-II function. ATP is critical for phosphorylation reactions, and its abundance can indirectly upregulate glycosylation processes involving St3Gal-II. S-Adenosylmethionine (SAM) serves as a methyl donor that can impact glycosylation pathways, affecting the activity of St3Gal-II. Tunicamycin, by inhibiting other glycosylation processes, leads to substrate accumulation and a compensatory upregulation of St3Gal-II activity. Lastly, 4-Methylumbelliferyl α-D-N-acetylneuraminide, as a fluorogenic substrate for sialidases, can reflect the activity of St3Gal-II by highlighting the balance between sialylation and desialylation, indirectly inferring the enhanced activity of the sialyltransferase.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Forskolin | 66575-29-9 | sc-3562 sc-3562A sc-3562B sc-3562C sc-3562D | 5 mg 50 mg 1 g 2 g 5 g | $78.00 $153.00 $740.00 $1413.00 $2091.00 | 73 | |
Forskolin directly stimulates adenylyl cyclase, leading to an increase in intracellular cAMP levels. Elevated cAMP activates PKA, which can phosphorylate various substrates, including those that can enhance the glycosylation processes St3Gal-II is involved in. | ||||||
8-Bromoadenosine 3′,5′-cyclic monophosphate | 23583-48-4 | sc-217493B sc-217493 sc-217493A sc-217493C sc-217493D | 25 mg 50 mg 100 mg 250 mg 500 mg | $108.00 $169.00 $295.00 $561.00 $835.00 | 2 | |
This cAMP analog is resistant to degradation and mimics the action of cAMP by activating PKA. This activation can enhance the activity of St3Gal-II by promoting the glycosylation of proteins and lipids which St3Gal-II facilitates. | ||||||
Manganese(II) chloride beads | 7773-01-5 | sc-252989 sc-252989A | 100 g 500 g | $19.00 $31.00 | ||
Manganese chloride is a cofactor that is essential for the optimal activity of glycosyltransferases, including St3Gal-II. The presence of Mn(II) ions can enhance the enzymatic function of St3Gal-II by improving substrate binding and catalysis. | ||||||
UDP-α-D-Galactose disodium salt | 137868-52-1 | sc-286849 sc-286849A sc-286849B | 10 mg 50 mg 1 g | $104.00 $198.00 $2968.00 | 1 | |
Uridine diphosphate galactose (UDP-Galactose) is a direct substrate for St3Gal-II in the biosynthesis of glycosphingolipids and other glycoconjugates. The availability of this sugar nucleotide can enhance the glycosylation activity of St3Gal-II. | ||||||
Adenosine 5′-Triphosphate, disodium salt | 987-65-5 | sc-202040 sc-202040A | 1 g 5 g | $39.00 $75.00 | 9 | |
ATP provides the phosphate group in the phosphorylation reactions that are crucial for many signaling pathways. Enhanced phosphorylation can lead to upregulation of glycosylation processes that St3Gal-II is part of. | ||||||
Ademetionine | 29908-03-0 | sc-278677 sc-278677A | 100 mg 1 g | $184.00 $668.00 | 2 | |
SAM is a methyl donor in numerous methylation reactions and can influence the glycosylation pathways by methylation of certain substrates, which may affect the activity of St3Gal-II indirectly. | ||||||
Tunicamycin | 11089-65-9 | sc-3506A sc-3506 | 5 mg 10 mg | $172.00 $305.00 | 66 | |
Tunicamycin inhibits N-linked glycosylation, which can result in the accumulation of glycoproteins in the ER. This stress response can indirectly enhance the activity of other glycosylation processes, including those catalyzed by St3Gal-II. | ||||||