SSTR3 Inhibitors
SSTR3 inhibitors belong to a class of compounds that specifically target and inhibit the activity of the somatostatin receptor subtype 3 (SSTR3). Somatostatin receptors, part of the G-protein coupled receptor family, are widely distributed across various tissues and play a pivotal role in modulating cellular signaling pathways. The SSTR3 subtype is particularly interesting due to its involvement in the regulation of cyclic adenosine monophosphate (cAMP) production and its ability to influence calcium ion channels. Inhibiting SSTR3 allows researchers to explore the precise regulatory mechanisms this receptor exerts over cellular processes such as signal transduction, receptor-ligand interactions, and intracellular communication. The intricate dynamics of SSTR3-mediated pathways, especially when influenced by an inhibitor, offer insights into the functional specificity among the five known somatostatin receptor subtypes.
The chemical structure of SSTR3 inhibitors often includes elements that allow them to bind selectively to the receptor, often through interactions with the receptor's transmembrane domains. This selectivity ensures that these inhibitors block receptor activation without significantly affecting other receptor subtypes. Researchers studying SSTR3 inhibitors focus on understanding how inhibition impacts receptor desensitization, internalization, and recycling processes, along with downstream effects on second messengers like phosphoinositides or cAMP. Moreover, these inhibitors provide a platform for exploring the receptor's physiological role in homeostatic regulation across various organ systems. Their study can uncover essential aspects of cellular feedback mechanisms, receptor cross-talk, and fine-tuning of signaling pathways, which are important for understanding receptor function at a molecular level.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Cyclopamine | 4449-51-8 | sc-200929 sc-200929A | 1 mg 5 mg | $92.00 $204.00 | 19 | |
Cyclopamine is a steroidal alkaloid and a potent inhibitor of the Hedgehog signaling pathway. It acts by specifically targeting Smoothened (Smo), a crucial component of the pathway. Smo inhibition by Cyclopamine disrupts downstream signaling events, including those involving SSTR3. | ||||||
Octreotide Acetate | 79517-01-4 | sc-397566 sc-397566A sc-397566B | 10 mg 25 mg 50 mg | $367.00 $445.00 $560.00 | ||
Octreotide is an analog of somatostatin and functions as a somatostatin receptor agonist. While it primarily targets somatostatin receptors, including SSTR2, it may indirectly influence SSTR3 signaling due to the shared downstream pathways. By activating somatostatin receptors, Octreotide can initiate signaling events that lead to the inhibition of adenylate cyclase and subsequent reduction in cyclic AMP levels. | ||||||
Temozolomide | 85622-93-1 | sc-203292 sc-203292A | 25 mg 100 mg | $89.00 $250.00 | 32 | |
Temozolomide is an alkylating agent studied in the research of certain types of cancer. It methylates DNA, leading to DNA damage and cell death. While its primary mechanism of action is in the context of cancer therapy, the DNA damage induced by Temozolomide can activate cellular stress responses, potentially influencing somatostatin receptor expression or function. | ||||||
Exendin-4 | 141758-74-9 | sc-474611 sc-474611A | 500 µg 1 mg | $143.00 $194.00 | 1 | |
Exendin-4 is a glucagon-like peptide-1 (GLP-1) receptor agonist commonly studied in the research of type 2 diabetes. Its primary mechanism of action involves the activation of GLP-1 receptors, leading to enhanced insulin secretion. While the direct impact of Exendin-4 on SSTR3 is not well-established, GLP-1 receptor signaling can intersect with pathways involving cyclic AMP and protein kinase A (PKA). | ||||||
Rapamycin | 53123-88-9 | sc-3504 sc-3504A sc-3504B | 1 mg 5 mg 25 mg | $62.00 $155.00 $320.00 | 233 | |
Rapamycin is an immunosuppressive and antiproliferative agent that inhibits the mammalian target of rapamycin (mTOR) pathway. While its primary use is in the context of immunosuppression, mTOR signaling can intersect with pathways implicated in somatostatin receptor regulation. By inhibiting mTOR, Rapamycin may influence cellular processes that indirectly modulate SSTR3 expression or function. | ||||||
Curcumin | 458-37-7 | sc-200509 sc-200509A sc-200509B sc-200509C sc-200509D sc-200509F sc-200509E | 1 g 5 g 25 g 100 g 250 g 1 kg 2.5 kg | $36.00 $68.00 $107.00 $214.00 $234.00 $862.00 $1968.00 | 47 | |
Curcumin is a natural polyphenol with anti-inflammatory and antioxidant properties. It has been reported to modulate various signaling pathways, including those involving cyclic AMP and protein kinase A (PKA). Since SSTR3 signaling is influenced by cyclic AMP and PKA, Curcumin's ability to modulate these pathways suggests a potential indirect impact on SSTR3 function. | ||||||
Gallein | 2103-64-2 | sc-202631 | 50 mg | $83.00 | 20 | |
Gallein is a small molecule that has been reported as a G protein-coupled receptor kinase (GRK) inhibitor. While the direct impact of Gallein on SSTR3 is not fully elucidated, GRKs play a role in the desensitization of G protein-coupled receptors, including somatostatin receptors. Inhibition of GRKs by Gallein may potentially affect the desensitization process of SSTR3, leading to prolonged signaling. | ||||||
Wortmannin | 19545-26-7 | sc-3505 sc-3505A sc-3505B | 1 mg 5 mg 20 mg | $66.00 $219.00 $417.00 | 97 | |
Wortmannin is a phosphoinositide 3-kinase (PI3K) inhibitor that disrupts signaling pathways involved in cell survival and growth. While its primary use is in the context of PI3K inhibition, the broader impact of Wortmannin on cellular processes may indirectly influence SSTR3 expression or function. | ||||||
GW 5074 | 220904-83-6 | sc-200639 sc-200639A | 5 mg 25 mg | $106.00 $417.00 | 10 | |
GW5074 is a specific inhibitor of c-Raf, a kinase involved in the Ras-Raf-MEK-ERK signaling pathway. While its primary mechanism of action is in the context of c-Raf inhibition, the Ras-Raf-MEK-ERK pathway intersects with signaling cascades implicated in somatostatin receptor regulation. By inhibiting c-Raf, GW5074 may indirectly influence SSTR3 expression or function through modulation of shared downstream pathways. | ||||||