SPOP Activators
SPOP activators make up a class of compounds that have been shown to induce the expression and upregulation of the SPOP protein. These activators primarily function through modulating the activity of various transcription factors and signaling pathways that regulate SPOP levels. One of the main transcription factors involved is Nrf2, which drives the expression of many antioxidant and cytoprotective genes. Many SPOP activators either directly facilitate the stabilization and nuclear accumulation of Nrf2 or indirectly activate Nrf2 signaling through related pathways.
For example, certain activators disrupt the interaction between Nrf2 and its inhibitor Keap1. This allows Nrf2 to evade ubiquitination and proteasomal degradation, leading to increased Nrf2 protein levels and activity. Other activators phosphorylate Nrf2 to promote its binding to antioxidant response elements and enhance transcriptional output of genes governed by these regulatory sequences. Several activators also function through additional transcription factors or signaling cascades that are linked to Nrf2, such as AMPK. By inducing AMPK activity, specific SPOP activators can stimulate Nrf2-mediated gene expression and SPOP upregulation. Overall, SPOP activators modulate the cellular levels of this important protein by targeting various upstream mediators of SPOP expression, predominantly the Nrf2 signaling node. Further elucidating the modes of action and molecular effects of different SPOP activators may provide novel insights into regulatory mechanisms controlling SPOP.
Items 1 to 10 of 12 total
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Resveratrol | 501-36-0 | sc-200808 sc-200808A sc-200808B | 100 mg 500 mg 5 g | $60.00 $185.00 $365.00 | 64 | |
Resveratrol is a stilbenoid found in certain plants and has shown to induce the expression of SPOP through its activator properties on related transcription factors and signaling pathways. | ||||||
Curcumin | 458-37-7 | sc-200509 sc-200509A sc-200509B sc-200509C sc-200509D sc-200509F sc-200509E | 1 g 5 g 25 g 100 g 250 g 1 kg 2.5 kg | $36.00 $68.00 $107.00 $214.00 $234.00 $862.00 $1968.00 | 47 | |
Found in turmeric, curcumin has anti-inflammatory abilities and stimulates the Nrf2 pathway which is linked to upregulation of SPOP at the transcriptional level. | ||||||
D,L-Sulforaphane | 4478-93-7 | sc-207495A sc-207495B sc-207495C sc-207495 sc-207495E sc-207495D | 5 mg 10 mg 25 mg 1 g 10 g 250 mg | $150.00 $286.00 $479.00 $1299.00 $8299.00 $915.00 | 22 | |
DL-Sulforaphane induces SPOP by activating the Nrf2 transcription factor response to oxidative stressors and increasing expression of antioxidant genes. | ||||||
Silybin | 22888-70-6 | sc-202812 sc-202812A sc-202812B sc-202812C | 1 g 5 g 10 g 50 g | $54.00 $112.00 $202.00 $700.00 | 6 | |
The major flavolignan component of milk thistle, Silybin modulates Keap1/Nrf2 interactions leading to stabilization of Nrf2 and probable increased transcription of SPOP. | ||||||
Quercetin | 117-39-5 | sc-206089 sc-206089A sc-206089E sc-206089C sc-206089D sc-206089B | 100 mg 500 mg 100 g 250 g 1 kg 25 g | $11.00 $17.00 $108.00 $245.00 $918.00 $49.00 | 33 | |
A plant-derived flavonol, quercetin increases Nrf2 protein stability and transcriptional activity which may result in higher SPOP expression through related signaling cascades. | ||||||
Berberine | 2086-83-1 | sc-507337 | 250 mg | $90.00 | 1 | |
An alkaloid found in plants such as barberry, berberine induces SPOP by preventing nuclear export of Nrf2 and prolonging its transcriptional effects on target genes. | ||||||
Apigenin | 520-36-5 | sc-3529 sc-3529A sc-3529B sc-3529C sc-3529D sc-3529E sc-3529F | 5 mg 100 mg 1 g 5 g 25 g 100 g 1 kg | $32.00 $210.00 $720.00 $1128.00 $2302.00 $3066.00 $5106.00 | 22 | |
This flavone present in many plants activates Nrf2 and increases expression of cytoprotective genes controlled by antioxidant response elements on their promoters such as SPOP. | ||||||
Baicalein | 491-67-8 | sc-200494 sc-200494A sc-200494B sc-200494C | 10 mg 100 mg 500 mg 1 g | $31.00 $41.00 $159.00 $286.00 | 12 | |
Isolated from skullcap, baicalein inhibits Nrf2 ubiquitination and proteolysis thereby blocking its degradation and allowing accumulation to trigger upregulation of genes like SPOP. | ||||||
Kaempferol | 520-18-3 | sc-202679 sc-202679A sc-202679B | 25 mg 100 mg 1 g | $97.00 $212.00 $500.00 | 11 | |
This flavonol induces SPOP expression by activating AMPK which phosphorylates Nrf2 leading to enhanced binding to antioxidant response elements and transcriptional output. | ||||||
Embelin | 550-24-3 | sc-201555 sc-201555A | 10 mg 50 mg | $87.00 $332.00 | 5 | |
Found in emblic leaves, embelin facilitates Nrf2 nuclear localization and extends its half-life in the nucleus to potentiate expression of target genes including SPOP. | ||||||