Spo11 Activators
Spo11 Activators can be considered a group of compounds that cause DNA damage or induce replication stress, potentially stimulating Spo11 activity. These compounds, which include Bleomycin, Mitomycin C, Etoposide, and Doxorubicin, interact with DNA in various ways to induce damage. Such damage could stimulate the activity of Spo11 as part of the cellular response to DNA damage.
Other compounds in this group cause replication stress, which could also potentially stimulate Spo11 activity. Hydroxyurea and Methotrexate, for instance, affect the availability of nucleotides for DNA replication, leading to replication stress. Moreover, 5-Fluorouracil, 6-Thioguanine, 5-Azacytidine, and AZT are nucleotide analogs which, when incorporated into DNA during replication, cause DNA damage. These diverse compounds highlight the complex cellular processes that could potentially influence the activity of a protein like Spo11.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Bleomycin | 11056-06-7 | sc-507293 | 5 mg | $275.00 | 5 | |
Bleomycin induces DNA damage and could thereby stimulate DNA repair processes, potentially affecting Spo11 activity. | ||||||
Mitomycin C | 50-07-7 | sc-3514A sc-3514 sc-3514B | 2 mg 5 mg 10 mg | $66.00 $101.00 $143.00 | 85 | |
Mitomycin C induces DNA crosslinks and could stimulate DNA repair processes, potentially affecting Spo11 activity. | ||||||
Doxorubicin | 23214-92-8 | sc-280681 sc-280681A | 1 mg 5 mg | $176.00 $426.00 | 43 | |
Doxorubicin intercalates into DNA and causes DNA damage, potentially inducing Spo11 activity. | ||||||
Cisplatin | 15663-27-1 | sc-200896 sc-200896A | 100 mg 500 mg | $138.00 $380.00 | 101 | |
Cisplatin binds DNA and induces DNA damage, potentially stimulating Spo11 activity. | ||||||
Hydroxyurea | 127-07-1 | sc-29061 sc-29061A | 5 g 25 g | $78.00 $260.00 | 18 | |
Hydroxyurea inhibits ribonucleotide reductase, leading to a decrease in deoxyribonucleotides and causing replication stress, potentially affecting Spo11 activity. | ||||||
Fluorouracil | 51-21-8 | sc-29060 sc-29060A | 1 g 5 g | $37.00 $152.00 | 11 | |
5-Fluorouracil is incorporated into DNA during replication, causing DNA damage and potentially inducing Spo11 activity. | ||||||
6-Thioguanine | 154-42-7 | sc-205587 sc-205587A | 250 mg 500 mg | $42.00 $54.00 | 3 | |
6-Thioguanine is incorporated into DNA during replication, causing DNA damage and potentially inducing Spo11 activity. | ||||||
5-Azacytidine | 320-67-2 | sc-221003 | 500 mg | $280.00 | 4 | |
5-Azacytidine is incorporated into DNA during replication, causing DNA damage and potentially inducing Spo11 activity. | ||||||
Methotrexate | 59-05-2 | sc-3507 sc-3507A | 100 mg 500 mg | $94.00 $213.00 | 33 | |
Methotrexate inhibits dihydrofolate reductase, causing a decrease in nucleotides and inducing replication stress, potentially affecting Spo11 activity. | ||||||
3′-Azido-3′-deoxythymidine | 30516-87-1 | sc-203319 | 10 mg | $61.00 | 2 | |
3′-Azido-3′-deoxythymidine is incorporated into DNA during replication, causing DNA damage and potentially inducing Spo11 activity. | ||||||