Chemicals classified as indirect SPFH1 inhibitors encompass a variety of compounds that interact with cellular membranes, signaling pathways, and lipid rafts where SPFH1 is known to localize and exert its function. For instance, Genistein and Wortmannin are inhibitors of tyrosine kinases and PI3K, respectively, affecting the phosphatidylinositol signaling pathways that can modify the activity of proteins associated with membrane domains. U73122, by inhibiting phospholipase C, can alter the phospholipid turnover and impact SPFH1's interactions with membrane components.
Cholesterol and compounds that modulate cholesterol homeostasis, such as Methyl-β-cyclodextrin, Filipin, Nystatin, Simvastatin, and Lovastatin, can significantly influence the integrity and functionality of lipid rafts. These lipid-rich domains are critical for the localization and function of SPFH1. By altering the cholesterol content within these domains, these compounds can disrupt the structural platform necessary for SPFH1's role in signal transduction and membrane organization. Additionally, Dynasore and Manumycin A target GTPase and Ras farnesyltransferase, respectively, which are important for vesicular trafficking and signal transduction pathways that SPFH1 may be associated with. Lastly, Ionomycin, by altering intracellular calcium levels, can affect a broad spectrum of signaling cascades that might intersect with SPFH1's functional pathways. In summary, the indirect SPFH1 inhibitors listed are a diverse group of chemicals that can affect SPFH1 function by altering membrane cholesterol content, inhibiting enzymes involved in lipid and protein signaling pathways, and disrupting cellular processes such as endocytosis and vesicular trafficking
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Genistein | 446-72-0 | sc-3515 sc-3515A sc-3515B sc-3515C sc-3515D sc-3515E sc-3515F | 100 mg 500 mg 1 g 5 g 10 g 25 g 100 g | $26.00 $92.00 $120.00 $310.00 $500.00 $908.00 $1821.00 | 46 | |
A tyrosine kinase inhibitor that can affect cell signaling pathways involving SPFH1. | ||||||
Wortmannin | 19545-26-7 | sc-3505 sc-3505A sc-3505B | 1 mg 5 mg 20 mg | $66.00 $219.00 $417.00 | 97 | |
A PI3K inhibitor that could disrupt signaling pathways and membrane associations involving SPFH1. | ||||||
Cholesterol | 57-88-5 | sc-202539C sc-202539E sc-202539A sc-202539B sc-202539D sc-202539 | 5 g 5 kg 100 g 250 g 1 kg 25 g | $26.00 $2754.00 $126.00 $206.00 $572.00 $86.00 | 11 | |
Influences membrane microdomains where SPFH1 localizes; altered cholesterol levels can disrupt SPFH1 membrane associations. | ||||||
2-Hydroxypropyl-β-cyclodextrin | 128446-35-5 | sc-203461 sc-203461B sc-203461C sc-203461A | 1 g 100 g 500 g 5 g | $52.00 $620.00 $1950.00 $130.00 | 8 | |
Extracts cholesterol from membranes, potentially disrupting membrane compartments and SPFH1 function. | ||||||
Filipin III | 480-49-9 | sc-205323 sc-205323A | 500 µg 1 mg | $116.00 $145.00 | 26 | |
A polyene antibiotic that binds to cholesterol, possibly affecting SPFH1 localization and function by disturbing lipid rafts. | ||||||
Dynamin Inhibitor I, Dynasore | 304448-55-3 | sc-202592 | 10 mg | $87.00 | 44 | |
A GTPase inhibitor that can disrupt endocytosis, affecting SPFH1's role in membrane dynamics. | ||||||
Simvastatin | 79902-63-9 | sc-200829 sc-200829A sc-200829B sc-200829C | 50 mg 250 mg 1 g 5 g | $30.00 $87.00 $132.00 $434.00 | 13 | |
A statin that can lower cholesterol levels, potentially affecting SPFH1's membrane association. | ||||||
A23187 | 52665-69-7 | sc-3591 sc-3591B sc-3591A sc-3591C | 1 mg 5 mg 10 mg 25 mg | $54.00 $128.00 $199.00 $311.00 | 23 | |
Inhibits Ras farnesyltransferase, affecting Ras-mediated pathways and potentially SPFH1's associations with signaling complexes. | ||||||
Lovastatin | 75330-75-5 | sc-200850 sc-200850A sc-200850B | 5 mg 25 mg 100 mg | $28.00 $88.00 $332.00 | 12 | |
Another statin that lowers cholesterol, similarly affecting SPFH1's membrane associations. | ||||||
Ionomycin, free acid | 56092-81-0 | sc-263405 sc-263405A | 1 mg 5 mg | $94.00 $259.00 | 2 | |
Increases intracellular calcium levels, which can affect various signaling pathways and potentially influence SPFH1 activity. | ||||||