Sox-14 Activators
Sox-14 Activators are a diverse array of chemical compounds that enhance the functional activity of Sox-14 through various cellular mechanisms and signaling pathways. These activators include Forskolin, which raises intracellular cAMP levels and activates PKA, potentially leading to the phosphorylation and heightened transcriptional activity of Sox-14. Similarly, db-cAMP, a cAMP analog, directly stimulates PKA, which could enhance Sox-14's role in developmental gene regulation. PMA, by activating PKC, may also phosphorylate Sox-14, thereby facilitating its nuclear localization and increasing its DNA binding affinity. The PI3K inhibitor LY294002 and p38 MAPK inhibitor SB203580 may indirectly augment Sox-14 function by mitigating inhibitory controls, potentially increasing Sox-14's participation in neural development and differentiation pathways.
Furthermore, both 5-Azacytidine and Trichostatin A modulate chromatin structure, with the former reducing DNA methylation and the latter increasinghistone acetylation, which could promote enhanced expression and activity of Sox-14 in cellular fate decisions. Retinoic acid, by modulating gene expression through its receptors, can facilitate the differentiation pathways where Sox-14 plays a regulatory role, leading to its activation. Epigallocatechin gallate (EGCG) could indirectly boost Sox-14 activity by inhibiting kinases that negatively regulate this protein, while Spermidine might enhance Sox-14's activity through autophagy-mediated degradation of its negative regulators. Lithium chloride's inhibition of GSK-3β may stabilize Sox-14, enhancing its transcriptional activity. Lastly, Sildenafil through PDE5 inhibition, and consequently increased cAMP and cGMP levels, may bolster Sox-14's involvement in neurogenesis, showcasing the intricate network of biochemical pathways that collectively contribute to the enhancement of Sox-14's function.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Forskolin | 66575-29-9 | sc-3562 sc-3562A sc-3562B sc-3562C sc-3562D | 5 mg 50 mg 1 g 2 g 5 g | $76.00 $150.00 $725.00 $1385.00 $2050.00 | 73 | |
Forskolin activates adenylyl cyclase, leading to increased levels of cyclic AMP (cAMP) within the cell. Elevated cAMP activates protein kinase A (PKA), which may phosphorylate Sox-14, leading to its enhanced functional activity in transcriptional regulation. | ||||||
PMA | 16561-29-8 | sc-3576 sc-3576A sc-3576B sc-3576C sc-3576D | 1 mg 5 mg 10 mg 25 mg 100 mg | $40.00 $129.00 $210.00 $490.00 $929.00 | 119 | |
PMA activates protein kinase C (PKC), which can phosphorylate transcription factors and other proteins. PKC-mediated phosphorylation could enhance Sox-14 activity by promoting its nuclear localization or its binding affinity to DNA. | ||||||
SB 203580 | 152121-47-6 | sc-3533 sc-3533A | 1 mg 5 mg | $88.00 $342.00 | 284 | |
SB203580 is an inhibitor of p38 MAPK. Inhibition of p38 MAPK can shift the cellular signaling dynamics, possibly relieving inhibitory control over Sox-14, allowing for its enhanced activity in cellular differentiation processes. | ||||||
LY 294002 | 154447-36-6 | sc-201426 sc-201426A | 5 mg 25 mg | $121.00 $392.00 | 148 | |
LY294002 is a PI3K inhibitor, which can lead to reduced Akt phosphorylation. This reduction may alleviate inhibitory effects on factors that control Sox-14, thus indirectly enhancing Sox-14's activity in neural development. | ||||||
5-Azacytidine | 320-67-2 | sc-221003 | 500 mg | $280.00 | 4 | |
5-Azacytidine inhibits DNA methyltransferases, leading to reduced methylation of DNA. Hypomethylation of the Sox-14 gene promoter could lead to enhanced transcription and activity of Sox-14 in cell fate decisions. | ||||||
Trichostatin A | 58880-19-6 | sc-3511 sc-3511A sc-3511B sc-3511C sc-3511D | 1 mg 5 mg 10 mg 25 mg 50 mg | $149.00 $470.00 $620.00 $1199.00 $2090.00 | 33 | |
TSA is a histone deacetylase inhibitor which leads to increased histone acetylation. Increased acetylation may promote the accessibility of transcription factors like Sox-14 to their target genes, enhancing gene expression. | ||||||
Retinoic Acid, all trans | 302-79-4 | sc-200898 sc-200898A sc-200898B sc-200898C | 500 mg 5 g 10 g 100 g | $65.00 $319.00 $575.00 $998.00 | 28 | |
Retinoic acid modulates gene expression through its receptors. It can enhance Sox-14 activity by promoting differentiation pathways in which Sox-14 is a critical regulatory factor. | ||||||
(−)-Epigallocatechin Gallate | 989-51-5 | sc-200802 sc-200802A sc-200802B sc-200802C sc-200802D sc-200802E | 10 mg 50 mg 100 mg 500 mg 1 g 10 g | $42.00 $72.00 $124.00 $238.00 $520.00 $1234.00 | 11 | |
EGCG has been shown to inhibit various protein kinases. Inhibition of these kinases could reduce negative regulatory influences on Sox-14, potentially enhancing its role in neurogenesis. | ||||||
Spermidine | 124-20-9 | sc-215900 sc-215900B sc-215900A | 1 g 25 g 5 g | $56.00 $595.00 $173.00 | ||
Spermidine induces autophagy which can lead to the degradation of proteins that negatively regulate Sox-14, thereby indirectly enhancing Sox-14's transcriptional activity in development. | ||||||
Lithium | 7439-93-2 | sc-252954 | 50 g | $214.00 | ||
Lithium chloride inhibits GSK-3β, which can lead to enhanced stability and activity of transcription factors. This inhibition might enhance Sox-14 activity by stabilizing it or facilitating its nuclear translocation. | ||||||