SNAP 29 Activators
SNAP-29 Activators represent a unique class of compounds that specifically target and enhance the functional activity of the SNAP-29 protein, a member of the Soluble NSF Attachment Protein Receptor (SNARE) family involved in mediating vesicle fusion in various cellular processes. These activators are characterized by their ability to influence the intricate regulatory mechanisms that govern vesicle trafficking, which is crucial for synaptic transmission, endocytosis, and exocytosis. The activation of SNAP-29 is a nuanced process, involving the stabilization of the SNARE complex and ensuring the proper alignment and interaction necessary for vesicle fusion. By bolstering the efficiency of this protein, SNAP-29 Activators play a pivotal role in optimizing intracellular transport and the precise delivery of vesicular contents.
The mode of action of SNAP-29 Activators is often rooted in their ability to modulate the protein-protein interactions that are essential for SNAP-29's role in vesicle docking and fusion. These compounds can enhance the binding affinity of SNAP-29 to its partner SNARE proteins, such as Syntaxin or VAMP, which in turn facilitates the rate and specificity of vesicular transport. Some activators may also function by promoting the recycling or redistribution of SNAP-29 to active sites within the cell, thereby amplifying its availability and functional readiness. The enhanced activity of SNAP-29, as a result of these activators, is critical to maintaining the fidelity of intracellular signaling and material exchange, which is foundational to cellular homeostasis and the execution of complex cellular functions. Through the precise modulation of SNAP-29, these activators ensure the agility and efficiency of vesicular traffic, a process integral to the life of a cell.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
PMA | 16561-29-8 | sc-3576 sc-3576A sc-3576B sc-3576C sc-3576D | 1 mg 5 mg 10 mg 25 mg 100 mg | $40.00 $129.00 $210.00 $490.00 $929.00 | 119 | |
PMA acts as a diacylglycerol analog to activate protein kinase C (PKC). PKC activation can lead to phosphorylation events that enhance the vesicle trafficking process, where SNAP 29 is a critical component, thus indirectly enhancing the activity of SNAP 29. | ||||||
Forskolin | 66575-29-9 | sc-3562 sc-3562A sc-3562B sc-3562C sc-3562D | 5 mg 50 mg 1 g 2 g 5 g | $76.00 $150.00 $725.00 $1385.00 $2050.00 | 73 | |
Forskolin stimulates adenylate cyclase, increasing cAMP levels which activate PKA. PKA can phosphorylate various proteins involved in vesicular transport, potentially enhancing the vesicle fusion processes that involve SNAP 29. | ||||||
Ionomycin | 56092-82-1 | sc-3592 sc-3592A | 1 mg 5 mg | $76.00 $265.00 | 80 | |
Ionomycin is a calcium ionophore that raises intracellular calcium levels, activating calcium-dependent protein kinases. These kinases can modify the vesicle docking and fusion machinery, indirectly enhancing SNAP 29's role in these processes. | ||||||
Brefeldin A | 20350-15-6 | sc-200861C sc-200861 sc-200861A sc-200861B | 1 mg 5 mg 25 mg 100 mg | $30.00 $52.00 $122.00 $367.00 | 25 | |
Brefeldin A disrupts the ADP-ribosylation factor (ARF) which is involved in vesicle formation. By inhibiting ARF, brefeldin A can lead to compensatory mechanisms that potentially upregulate vesicular transport processes involving SNAP 29. | ||||||
Monensin A | 17090-79-8 | sc-362032 sc-362032A | 5 mg 25 mg | $152.00 $515.00 | ||
Monensin is an ionophore that alters intracellular pH and sodium concentration, impacting endosomal trafficking. This alteration can modulate the endosomal sorting processes in which SNAP 29 is a key facilitator, thereby enhancing its activity. | ||||||
Adenosine 3′,5′-cyclic Monophosphate, N6-Benzoyl-, Sodium Salt | 30275-80-0 | sc-300167 | 10 µmol | $318.00 | 1 | |
This cAMP analog activates PKA, leading to phosphorylation of proteins within the vesicle trafficking pathway. Enhanced phosphorylation can improve vesicular transport efficiency, indirectly increasing SNAP 29's functional activity in these pathways. | ||||||
Okadaic Acid | 78111-17-8 | sc-3513 sc-3513A sc-3513B | 25 µg 100 µg 1 mg | $285.00 $520.00 $1300.00 | 78 | |
Okadaic Acid is a potent inhibitor of protein phosphatases 1 and 2A, preventing dephosphorylation of proteins involved in vesicular transport, potentially maintaining an environment that promotes SNAP 29's function in vesicle docking and fusion. | ||||||
A23187 | 52665-69-7 | sc-3591 sc-3591B sc-3591A sc-3591C | 1 mg 5 mg 10 mg 25 mg | $54.00 $128.00 $199.00 $311.00 | 23 | |
A23187 acts as a calcium ionophore leading to increased intracellular calcium, which activates calmodulin-dependent kinases. These kinases can potentiate the vesicle fusion process, potentially enhancing the activity of SNAP 29 in exocytosis. | ||||||
Tunicamycin | 11089-65-9 | sc-3506A sc-3506 | 5 mg 10 mg | $169.00 $299.00 | 66 | |
Tunicamycin inhibits N-linked glycosylation, which can induce ER stress leading to the unfolded protein response. This response may enhance the secretory pathway, indirectly increasing SNAP 29's role in membrane fusion and trafficking. | ||||||
Nocodazole | 31430-18-9 | sc-3518B sc-3518 sc-3518C sc-3518A | 5 mg 10 mg 25 mg 50 mg | $58.00 $83.00 $140.00 $242.00 | 38 | |
Nocodazole disrupts microtubule polymerization, which can lead to a reorganization of intracellular transport pathways. This reorganization may enhance vesicular transport processes that are reliant on SNAP 29 for membrane fusion. | ||||||