SMYD2 Activators
The class of SMYD2 activators is characterized by a variety of chemicals that can indirectly influence the activity of SMYD2 through their effects on epigenetic regulation and chromatin remodeling. These activators primarily act by altering the epigenetic landscape, which includes changes in DNA methylation and histone acetylation, thereby creating a cellular environment conducive to the modulation of SMYD2 activity. Compounds such as Sodium Butyrate, Trichostatin A, SAHA, and Nicotinamide function as inhibitors of histone deacetylases. Their role in increasing histone acetylation can indirectly enhance the activity of SMYD2 in histone methylation, as these epigenetic modifications often work in concert to regulate gene expression and chromatin structure. Additionally, agents like 5-Aza-2'-deoxycytidine, which alters DNA methylation patterns, can also impact the function of SMYD2, considering the interconnected nature of DNA and histone methylation in epigenetic regulation.
Furthermore, compounds involved in methylation processes such as Methylcobalamin, Folic Acid, and S-Adenosylmethionine can indirectly affect SMYD2 activity by influencing the cellular methylation capacity. The presence of these compounds could potentially enhance the methyltransferase activity of SMYD2. Retinoic Acid and Vitamin D3, through their roles in gene regulation and cellular differentiation, might also create a cellular context that influences SMYD2 activity. Similarly, Beta-Estradiol and Epigallocatechin Gallate, known for their impact on gene expression and epigenetic markers, could indirectly modulate the activity of SMYD2.
SEE ALSO...
Items 1 to 10 of 12 total
Display:
| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Sodium Butyrate | 156-54-7 | sc-202341 sc-202341B sc-202341A sc-202341C | 250 mg 5 g 25 g 500 g | $31.00 $47.00 $84.00 $222.00 | 19 | |
Sodium Butyrate acts as a histone deacetylase inhibitor, influencing chromatin structure and gene expression. This alteration in the epigenetic landscape could create a cellular environment that indirectly increases the activity of SMYD2 in its role in histone methylation. | ||||||
Trichostatin A | 58880-19-6 | sc-3511 sc-3511A sc-3511B sc-3511C sc-3511D | 1 mg 5 mg 10 mg 25 mg 50 mg | $152.00 $479.00 $632.00 $1223.00 $2132.00 | 33 | |
TSA is another histone deacetylase inhibitor. By modifying the acetylation status of histones, it can indirectly influence SMYD2's role in chromatin remodeling and gene regulation. | ||||||
Suberoylanilide Hydroxamic Acid | 149647-78-9 | sc-220139 sc-220139A | 100 mg 500 mg | $133.00 $275.00 | 37 | |
SAHA, similar to Sodium Butyrate and TSA, functions as a histone deacetylase inhibitor. Its impact on chromatin structure can create conditions that potentially enhance the activity of SMYD2 in histone methylation. | ||||||
Nicotinamide | 98-92-0 | sc-208096 sc-208096A sc-208096B sc-208096C | 100 g 250 g 1 kg 5 kg | $44.00 $66.00 $204.00 $831.00 | 6 | |
Nicotinamide, a form of Vitamin B3, acts as an inhibitor of sirtuins, another class of histone deacetylases. By influencing histone acetylation, it can indirectly affect SMYD2’s role in chromatin modification. | ||||||
5-Aza-2′-Deoxycytidine | 2353-33-5 | sc-202424 sc-202424A sc-202424B | 25 mg 100 mg 250 mg | $218.00 $322.00 $426.00 | 7 | |
A DNA methyltransferase inhibitor, it changes the DNA methylation landscape, potentially influencing SMYD2 activity in histone methylation as part of a broader epigenetic regulatory mechanism. | ||||||
Mecobalamin | 13422-55-4 | sc-211781 | 10 mg | $306.00 | ||
As an essential cofactor in methylation reactions, Methylcobalamin might indirectly influence SMYD2 activity by altering the cellular methylation capacity, including that of histones. | ||||||
Folic Acid | 59-30-3 | sc-204758 | 10 g | $73.00 | 2 | |
Folic Acid is crucial in one-carbon metabolism and thus indirectly influences DNA and histone methylation processes. This might impact SMYD2's activity in epigenetic regulation. | ||||||
Ademetionine | 29908-03-0 | sc-278677 sc-278677A | 100 mg 1 g | $184.00 $668.00 | 2 | |
As a universal methyl donor in the cell, SAMe plays a role in various methylation reactions, including histone methylation, potentially influencing SMYD2 activity. | ||||||
Retinoic Acid, all trans | 302-79-4 | sc-200898 sc-200898A sc-200898B sc-200898C | 500 mg 5 g 10 g 100 g | $66.00 $325.00 $587.00 $1018.00 | 28 | |
Involved in gene regulation and cellular differentiation, Retinoic Acid can alter the expression of various genes, potentially influencing the activity of SMYD2 in epigenetic regulation. | ||||||
Cholecalciferol | 67-97-0 | sc-205630 sc-205630A sc-205630B | 1 g 5 g 10 g | $71.00 $163.00 $296.00 | 2 | |
Vitamin D3 influences gene expression and cellular differentiation. It could indirectly modulate SMYD2 activity by altering the cellular context in which SMYD2 operates. | ||||||