SLTM Activators
SLTM Activators encompass a range of chemical compounds that indirectly boost the functional activity of SLTM through distinct signaling pathways. Forskolin and Rolipram, for instance, enhance SLTM's functional activity by increasing intracellular cAMP, which subsequently activates protein kinase A (PKA). PKA is known for its ability to phosphorylate proteins, potentially including SLTM, thereby enhancing its role in RNA processing and metabolism. Similarly, Sildenafil, through the inhibition of phosphodiesterase 5, heightens cGMP levels, leading to the activation of protein kinase G (PKG). PKG could then phosphorylate SLTM, augmenting its activity in mRNA export and processing. On another front, Phorbol 12-myristate 13-acetate (PMA) and Ionomycin act by activating PKC and increasing intracellular calcium levels, respectively, both of which may result in the phosphorylation and consequent activation of SLTM, implicating it in various mRNA metabolic processes.
The functional capabilities of SLTM are further influenced by compounds that modulate specific protein kinases and signaling molecules. EGCG, by inhibiting protein kinases, and Curcumin, by regulating the NF-κB pathway, may both enhance the role of SLTM in RNA metabolic processes. Resveratrol activates SIRT1, potentially leading to the deacetylation of SLTM, which could enhance its activity in RNA biogenesis. Additionally, Lithium chloride and SB 216763 both inhibit GSK-3, potentially preventing the phosphorylation-based inhibition of SLTM and thereby enhancing its post-transcriptional gene regulation capabilities. Dibutyryl cyclic AMP (db-cAMP), a cell-permeable analog of cAMP, and A-769662, an activator of AMP-activated protein kinase (AMPK), both serve to activate PKA and AMPK respectively. This activation could lead to the phosphorylation and enhancement of SLTM's function in RNA surveillance and editing, showcasing the diverse mechanisms through which these activators can bolster SLTM's role in RNA-related cellular activities.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Forskolin | 66575-29-9 | sc-3562 sc-3562A sc-3562B sc-3562C sc-3562D | 5 mg 50 mg 1 g 2 g 5 g | $78.00 $153.00 $740.00 $1413.00 $2091.00 | 73 | |
Forskolin directly stimulates adenylate cyclase, which increases cAMP levels in cells. Elevated cAMP activates PKA, which can phosphorylate SLTM, leading to its enhanced functional activity in RNA processing. | ||||||
PMA | 16561-29-8 | sc-3576 sc-3576A sc-3576B sc-3576C sc-3576D | 1 mg 5 mg 10 mg 25 mg 100 mg | $41.00 $132.00 $214.00 $500.00 $948.00 | 119 | |
PMA activates protein kinase C (PKC), which has been implicated in phosphorylation events that can modify the activity of RNA-binding proteins. The activation of PKC can thus indirectly increase the functional activity of SLTM in mRNA metabolism. | ||||||
Ionomycin | 56092-82-1 | sc-3592 sc-3592A | 1 mg 5 mg | $78.00 $270.00 | 80 | |
Ionomycin increases intracellular calcium concentration, which can activate calcium/calmodulin-dependent protein kinase (CaMK). This kinase could phosphorylate SLTM, resulting in its enhanced activity in mRNA splicing. | ||||||
Rolipram | 61413-54-5 | sc-3563 sc-3563A | 5 mg 50 mg | $77.00 $216.00 | 18 | |
Rolipram inhibits phosphodiesterase 4, leading to an increase in cAMP levels, similarly to Forskolin. This increase in cAMP can activate PKA, which may enhance SLTM's activity by phosphorylation. | ||||||
(−)-Epigallocatechin Gallate | 989-51-5 | sc-200802 sc-200802A sc-200802B sc-200802C sc-200802D sc-200802E | 10 mg 50 mg 100 mg 500 mg 1 g 10 g | $43.00 $73.00 $126.00 $243.00 $530.00 $1259.00 | 11 | |
EGCG is known to inhibit several protein kinases, which could reduce negative regulatory phosphorylation events on SLTM, thus potentiating its role in RNA metabolic processes. | ||||||
Curcumin | 458-37-7 | sc-200509 sc-200509A sc-200509B sc-200509C sc-200509D sc-200509F sc-200509E | 1 g 5 g 25 g 100 g 250 g 1 kg 2.5 kg | $37.00 $69.00 $109.00 $218.00 $239.00 $879.00 $1968.00 | 47 | |
Curcumin is a modulator of the NF-κB pathway, which has been shown to interact with signaling pathways involving RNA-binding proteins. By modulating NF-κB activity, curcumin may promote SLTM's function in gene expression regulation. | ||||||
Resveratrol | 501-36-0 | sc-200808 sc-200808A sc-200808B | 100 mg 500 mg 5 g | $80.00 $220.00 $460.00 | 64 | |
Resveratrol activates SIRT1, which is a deacetylase that can deacetylate and thereby activate various proteins. SIRT1 activation might enhance SLTM activity through deacetylation, facilitating its role in RNA biogenesis. | ||||||
Lithium | 7439-93-2 | sc-252954 | 50 g | $214.00 | ||
Lithium chloride inhibits glycogen synthase kinase-3 (GSK-3). Inhibition of GSK-3 may prevent phosphorylation-based inhibition of SLTM, enhancing its activity in RNA transport. | ||||||
SB-216763 | 280744-09-4 | sc-200646 sc-200646A | 1 mg 5 mg | $71.00 $202.00 | 18 | |
SB 216763 is another inhibitor of GSK-3. By inhibiting GSK-3, it might similarly prevent the phosphorylation-based inhibition of SLTM, thus enhancing its role in post-transcriptional gene regulation. | ||||||
Dibutyryl-cAMP | 16980-89-5 | sc-201567 sc-201567A sc-201567B sc-201567C | 20 mg 100 mg 500 mg 10 g | $47.00 $136.00 $492.00 $4552.00 | 74 | |
db-cAMP is a cell-permeable cAMP analog that activates PKA. PKA activation could lead to the phosphorylation and subsequent activation of SLTM in its role in mRNA surveillance. | ||||||