SLC41A2 Activators
Chemical activators of SLC41A2 can employ a variety of mechanisms to enhance the protein's function, which revolves around the transport of ions across cellular membranes. Magnesium chloride, for instance, supplies magnesium ions that are essential for the activity of many enzymes, including ion transporters like SLC41A2. The presence of magnesium can activate SLC41A2 by serving as a cofactor that is required for its optimal function. Similarly, zinc sulfate and copper sulfate provide divalent cations, zinc and copper respectively, which can bind to SLC41A2 and potentially induce conformational changes that enhance its ion transport capabilities. Barium chloride operates on a different principle; by acting as a surrogate for calcium, it can activate SLC41A2 by mimicking calcium's effects on ion transport processes.
On another front, several compounds focus on modulating the phosphorylation state of SLC41A2 to activate it. Sodium orthovanadate inhibits phosphatases, leading to a net increase in the phosphorylated (active) form of proteins, including SLC41A2. Forskolin and 3-isobutyl-1-methylxanthine increase the levels of cyclic AMP (cAMP), which in turn activates protein kinase A (PKA). PKA can phosphorylate SLC41A2, thereby enhancing its activity. Furthermore, ouabain increases intracellular sodium levels by inhibiting the Na+/K+ ATPase, which can indirectly activate SLC41A2 by altering the sodium gradient that SLC41A2 may utilize for its transport activity. Valinomycin, another activator, disrupts potassium gradients by acting as a potassium ionophore, which can have a compensatory effect on SLC41A2 activity to maintain ionic balance within the cell. Lastly, compounds like A23187 (Calcimycin) and verapamil increase intracellular calcium levels, which then activates calcium-dependent kinases that can target SLC41A2, leading to its enhanced activity. Each of these activators, by influencing the ionic environment or the phosphorylation state of SLC41A2, can thus modulate its activity in various cellular contexts.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Magnesium chloride | 7786-30-3 | sc-255260C sc-255260B sc-255260 sc-255260A | 10 g 25 g 100 g 500 g | $27.00 $34.00 $47.00 $123.00 | 2 | |
Magnesium is known to be a cofactor for many enzymes, including those that transport ions across cellular membranes. Magnesium chloride can activate SLC41A2 by providing the necessary magnesium ions for its proper function. | ||||||
Sodium Orthovanadate | 13721-39-6 | sc-3540 sc-3540B sc-3540A | 5 g 10 g 50 g | $45.00 $56.00 $183.00 | 142 | |
Sodium orthovanadate acts as a phosphatase inhibitor, which can lead to the phosphorylation of proteins involved in ion transport. This can activate SLC41A2 by promoting its phosphorylation state, enhancing its activity. | ||||||
Forskolin | 66575-29-9 | sc-3562 sc-3562A sc-3562B sc-3562C sc-3562D | 5 mg 50 mg 1 g 2 g 5 g | $76.00 $150.00 $725.00 $1385.00 $2050.00 | 73 | |
Forskolin activates adenylate cyclase, increasing cAMP levels, which can lead to the activation of PKA. PKA can then phosphorylate and activate SLC41A2, increasing its ion transport activity. | ||||||
IBMX | 28822-58-4 | sc-201188 sc-201188B sc-201188A | 200 mg 500 mg 1 g | $159.00 $315.00 $598.00 | 34 | |
This compound inhibits phosphodiesterases, leading to increased cAMP and activation of PKA. Activated PKA may phosphorylate SLC41A2, thereby increasing its activity. | ||||||
Zinc | 7440-66-6 | sc-213177 | 100 g | $47.00 | ||
Zinc ions can act as important regulatory cofactors for various ion transporters. Zinc sulfate can activate SLC41A2 by altering its conformation or charge distribution, enhancing its ability to transport ions. | ||||||
Copper(II) sulfate | 7758-98-7 | sc-211133 sc-211133A sc-211133B | 100 g 500 g 1 kg | $45.00 $120.00 $185.00 | 3 | |
Copper ions can bind to transporter proteins and modulate their activity. Copper sulfate may activate SLC41A2 directly by binding to it and inducing a conformational change that increases its function. | ||||||
Monensin A | 17090-79-8 | sc-362032 sc-362032A | 5 mg 25 mg | $152.00 $515.00 | ||
Monensin is an ionophore that alters intracellular ion concentrations, which can indirectly activate SLC41A2 by creating ion gradients that favor its transport activity. | ||||||
Ouabain-d3 (Major) | sc-478417 | 1 mg | $506.00 | |||
Ouabain inhibits the Na+/K+ ATPase, leading to increased intracellular sodium levels. This can indirectly activate SLC41A2 by altering the sodium gradient, which is a driving force for its activity. | ||||||
Valinomycin | 2001-95-8 | sc-200991 | 25 mg | $163.00 | 3 | |
Valinomycin is a potassium ionophore, which can alter the potassium gradient across the membrane. This may lead to the activation of SLC41A2 as it compensates for changes in intracellular potassium levels. | ||||||
A23187 | 52665-69-7 | sc-3591 sc-3591B sc-3591A sc-3591C | 1 mg 5 mg 10 mg 25 mg | $54.00 $128.00 $199.00 $311.00 | 23 | |
A23187 is an ionophore that increases intracellular calcium levels. Elevated calcium can activate calcium-dependent protein kinases that may phosphorylate and activate SLC41A2. | ||||||