SLC10A7 Inhibitors
Chemical inhibitors of SLC10A7 can interfere with its function through various mechanisms that impact the cellular environment and the activity of the transporter. Cyclosporin A, by inhibiting calcineurin, disrupts the phosphorylation state of numerous proteins, which can lead to altered expression of transporters including SLC10A7. Bafilomycin A1 targets V-ATPase, and its inhibition compromises endosomal acidification, essential for the trafficking and function of SLC10A7. Ouabain and Digoxin, by inhibiting Na+/K+-ATPase pump, cause an increase in intracellular Na+ concentration, affecting the Na+ gradient that SLC10A7 may rely on for its activity. The alteration of the Na+ gradient by these inhibitors can impede the transporter's ability to maintain its normal function.
Probenecid acts on organic anion transporters and can alter the function of SLC10A7 by modifying the cellular concentrations of substrates or competing ions. Verapamil and Nifedipine, as calcium channel blockers, impact the influx of calcium ions which may influence SLC10A7's activity by changing the electrochemical gradient of the cell. Amiloride's inhibition of the Na+/H+ exchanger can affect intracellular pH and Na+ levels, which are crucial for the activity of Na+-dependent transporters such as SLC10A7. Clotrimazole and Glyburide inhibit Ca2+-activated K+ channels and ATP-sensitive K+ channels, respectively. These channels contribute to setting the membrane potential, which, when altered, can impact the driving force behind the functioning of SLC10A7. Similarly, Tetrodotoxin, by blocking voltage-gated sodium channels, and Tetraethylammonium, by blocking potassium channels, can also influence the membrane potential and, consequently, the function of SLC10A7. The combined effect of these inhibitors can, therefore, impede the normal operation of SLC10A7 by altering the electrochemical landscape required for its activity.
SEE ALSO...
| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Cyclosporin A | 59865-13-3 | sc-3503 sc-3503-CW sc-3503A sc-3503B sc-3503C sc-3503D | 100 mg 100 mg 500 mg 10 g 25 g 100 g | $62.00 $90.00 $299.00 $475.00 $1015.00 $2099.00 | 69 | |
Cyclosporin A inhibits calcineurin, which is responsible for dephosphorylating numerous proteins, including transcription factors like NFAT that regulate the expression of key transporters and channels. Inhibition of calcineurin thus could lead to reduced expression of SLC10A7 as a downstream effect, since calcineurin affects transporters' regulation. | ||||||
Bafilomycin A1 | 88899-55-2 | sc-201550 sc-201550A sc-201550B sc-201550C | 100 µg 1 mg 5 mg 10 mg | $96.00 $250.00 $750.00 $1428.00 | 280 | |
Bafilomycin A1 is a specific inhibitor of the vacuolar-type H+-ATPase (V-ATPase). By inhibiting V-ATPase, it disrupts endosomal acidification, which is necessary for the proper trafficking and function of membrane proteins, including SLC10A7. | ||||||
Ouabain-d3 (Major) | sc-478417 | 1 mg | $506.00 | |||
Ouabain is a specific inhibitor of the Na+/K+-ATPase pump. By inhibiting this pump, the intracellular Na+ concentration increases, which can affect the Na+ gradient, thereby potentially influencing the function of Na+-dependent transporters like SLC10A7. | ||||||
Probenecid | 57-66-9 | sc-202773 sc-202773A sc-202773B sc-202773C | 1 g 5 g 25 g 100 g | $27.00 $38.00 $98.00 $272.00 | 28 | |
Probenecid inhibits organic anion transporters (OATs) and can indirectly inhibit the function of SLC10A7 by altering the cellular concentration of substrates or competing ions that may be necessary for SLC10A7 function. | ||||||
12β-Hydroxydigitoxin | 20830-75-5 | sc-213604 sc-213604A | 1 g 5 g | $140.00 $680.00 | ||
12β-Hydroxydigitoxin inhibits the Na+/K+-ATPase pump, similar to ouabain. It could indirectly inhibit SLC10A7 function by disrupting the Na+ gradient across the cell membrane, which may be necessary for SLC10A7's activity. | ||||||
Verapamil | 52-53-9 | sc-507373 | 1 g | $367.00 | ||
Verapamil is a calcium channel blocker that inhibits the influx of calcium ions. Altered intracellular calcium levels can affect various transporters and channels, including SLC10A7, by altering the electrochemical gradient. | ||||||
Nifedipine | 21829-25-4 | sc-3589 sc-3589A | 1 g 5 g | $58.00 $170.00 | 15 | |
Nifedipine is another calcium channel blocker that can alter intracellular calcium levels. Changes in calcium homeostasis could influence the activity of SLC10A7 by affecting the overall ionic environment of the cell. | ||||||
Amiloride | 2609-46-3 | sc-337527 | 1 g | $290.00 | 7 | |
Amiloride is a Na+/H+ exchanger inhibitor. By inhibiting this exchanger, the intracellular pH and Na+ concentration can be altered, which can influence the activity of Na+-dependent transporters like SLC10A7. | ||||||
Clotrimazole | 23593-75-1 | sc-3583 sc-3583A | 100 mg 1 g | $41.00 $56.00 | 6 | |
Clotrimazole is known to inhibit Ca2+-activated K+ channels. These channels help set the membrane potential, which can influence the driving force for transporters like SLC10A7 and potentially inhibit its function. | ||||||
Glyburide (Glibenclamide) | 10238-21-8 | sc-200982 sc-200982A sc-200982D sc-200982B sc-200982C | 1 g 5 g 25 g 100 g 500 g | $45.00 $60.00 $115.00 $170.00 $520.00 | 36 | |
Glyburide is an inhibitor of ATP-sensitive K+ channels. Inhibition of these channels affects the membrane potential and, consequently, could inhibit the function of transporters like SLC10A7 by altering the electrochemical gradient. | ||||||