SLA Inhibitors
SLA inhibitors, also known as sialic acid analog inhibitors, belong to a class of chemical compounds that target the enzyme sialic acid synthase. Sialic acid is a crucial component of glycoproteins and glycolipids, playing essential roles in various biological processes such as cell-cell interactions, immune response modulation, and signal transduction. Sialic acid synthase is responsible for catalyzing the biosynthesis of sialic acid from N-acetylmannosamine and phosphoenolpyruvate. By inhibiting this enzyme, SLA inhibitors disrupt the production of sialic acid, leading to downstream effects on cellular functions and processes that rely on sialic acid.
Structurally, SLA inhibitors are designed to mimic the structure of N-acetylmannosamine, the substrate of sialic acid synthase, allowing them to competitively bind to the enzyme's active site. This binding prevents the enzyme from effectively catalyzing the conversion of N-acetylmannosamine to sialic acid, ultimately inhibiting sialic acid biosynthesis. Due to the importance of sialic acid in various biological processes, the inhibition of sialic acid synthase by SLA inhibitors can have widespread effects on cellular function.
| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Dasatinib | 302962-49-8 | sc-358114 sc-358114A | 25 mg 1 g | $47.00 $145.00 | 51 | |
Tyrosine kinase inhibitor that affects Src family kinases. By inhibiting Src kinases, it can impact downstream SLA functions. | ||||||
PP 2 | 172889-27-9 | sc-202769 sc-202769A | 1 mg 5 mg | $92.00 $223.00 | 30 | |
Src kinase inhibitor that halts Src activation, thereby influencing proteins that interact with or are regulated by Src, like SLA. | ||||||
Imatinib | 152459-95-5 | sc-267106 sc-267106A sc-267106B | 10 mg 100 mg 1 g | $25.00 $117.00 $209.00 | 27 | |
Abl kinase inhibitor which indirectly can affect T-cell activation and SLA function. | ||||||
Syk Inhibitor IV, BAY 61-3606 HCl | 732983-37-8 | sc-202351 | 2 mg | $321.00 | 25 | |
Syk inhibitor. Syk is a protein tyrosine kinase involved in immunoreceptor signaling, potentially influencing SLA. | ||||||
R406 | 841290-81-1 | sc-364595 sc-364595A | 2 mg 10 mg | $160.00 $370.00 | 16 | |
Inhibitor of Syk kinase. By inhibiting Syk, it can affect signaling pathways that modulate SLA. | ||||||
Lck Inhibitor Inhibitor | 213743-31-8 | sc-204052 | 1 mg | $355.00 | 5 | |
Lck is a Src family kinase involved in TCR signaling, and its inhibition can influence SLA. | ||||||
Ibrutinib | 936563-96-1 | sc-483194 | 10 mg | $153.00 | 5 | |
Bruton's tyrosine kinase (BTK) inhibitor which can affect B-cell receptor signaling and thereby impact proteins like SLA. | ||||||
2-[[(1R,2S)-2-Aminocyclohexyl]amino]-4-[[3-(2H-1,2,3-triazol-2-yl)phenyl]amino]-5-pyrimidinecarboxamide Hydrochloride | 1370261-97-4 | sc-479864 | 5 mg | $380.00 | ||
Potent and selective Syk inhibitor, influencing pathways that SLA might be involved in. | ||||||
WHI-P 154 | 211555-04-3 | sc-204395 sc-204395A | 10 mg 50 mg | $150.00 $630.00 | 3 | |
JAK3 inhibitor; JAK3 is involved in several signaling pathways in T-cells, potentially influencing SLA. | ||||||
Saracatinib | 379231-04-6 | sc-364607 sc-364607A | 10 mg 200 mg | $113.00 $1035.00 | 7 | |
Inhibitor of Src and Abl kinases, influencing pathways that can indirectly modulate SLA. | ||||||