SKT Inhibitors

SKT inhibitors are chosen for their ability to indirectly influence its function in intervertebral disk development. These inhibitors target various signaling pathways and biological processes that are pivotal in development and cellular differentiation, which could impact SKT's role in the development of intervertebral disks. Compounds like Retinoic Acid, all trans and Cholecalciferol are crucial for embryonic development and bone health, respectively. Their influence on cellular differentiation and development could extend to affect SKT-related processes in intervertebral disk development.

Inhibitors of key signaling pathways like TGF-β (SB 431542), BMP (LDN-193189), Wnt (XAV939), FGF (PD173074), Hedgehog (Cyclopamine), Notch (DAPT), PDGF (Imatinib), mTOR (Rapamycin), and PI3K (LY 294002) provide a broad spectrum of modulators of SKT's function. These pathways are integral to various aspects of cellular development and differentiation, and modulating these pathways could influence the development of intervertebral disks and SKT's role in this process. Dexamethasone, a corticosteroid, is included for its effects on inflammation and cellular differentiation, which can be relevant in the context of intervertebral disk development.