Skint10 Inhibitors
Skint10 inhibitors are a class of chemical compounds designed to selectively block the function of the Skint10 protein, a member of the *Skint* family of immunoglobulin-like proteins. These proteins are primarily expressed in epithelial tissues and play a role in modulating immune cell interactions, particularly with γδ T cells, which are involved in maintaining epithelial homeostasis and responding to environmental stressors. Skint10 is thought to participate in signaling pathways that regulate the activation and development of these immune cells, influencing how epithelial tissues communicate with the immune system. Inhibitors of Skint10 work by binding to specific regions of the protein, preventing its interaction with other molecules or receptors essential for its function, thus interrupting its role in immune regulation.
The development of Skint10 inhibitors requires a deep understanding of the protein's structural and functional properties. Structural biology techniques such as X-ray crystallography, molecular docking, and computational modeling are commonly used to identify key domains on Skint10 that are critical for its interaction with other immune-related molecules. Once these target regions are mapped, small molecules or other inhibitors are designed to fit within these binding pockets, ensuring high specificity and minimal off-target effects. After synthesis, these inhibitors are evaluated using biochemical assays to measure their ability to bind to Skint10, their specificity, and their effectiveness in blocking Skint10-mediated signaling pathways. By studying Skint10 inhibitors, researchers gain insights into the biological role of Skint10 in immune cell regulation and the broader functions of the *Skint* family in maintaining the balance between immune surveillance and epithelial tissue integrity. This knowledge contributes to a better understanding of the intricate signaling mechanisms that govern immune-epithelial interactions.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Staurosporine | 62996-74-1 | sc-3510 sc-3510A sc-3510B | 100 µg 1 mg 5 mg | $82.00 $150.00 $388.00 | 113 | |
Staurosporine inhibits protein kinases that are critical for T cell receptor signaling, a pathway essential for the function of intraepithelial T cells 10. Inhibition of these kinases would impair T cell receptor-mediated activation and downstream functions, consequently inhibiting the activity of intraepithelial T cells 10. | ||||||
Wortmannin | 19545-26-7 | sc-3505 sc-3505A sc-3505B | 1 mg 5 mg 20 mg | $66.00 $219.00 $417.00 | 97 | |
Wortmannin is a potent inhibitor of phosphoinositide 3-kinases, which are involved in signaling pathways that support the survival and function of intraepithelial T cells 10. By inhibiting this kinase, Wortmannin can disrupt signaling required for intraepithelial T cells 10 activity. | ||||||
LY 294002 | 154447-36-6 | sc-201426 sc-201426A | 5 mg 25 mg | $121.00 $392.00 | 148 | |
LY294002 is another inhibitor of phosphoinositide 3-kinases, which play a role in the activation and function of intraepithelial T cells 10. Inhibition of PI3K by LY294002 can lead to reduced survival and function of intraepithelial T cells 10. | ||||||
U-0126 | 109511-58-2 | sc-222395 sc-222395A | 1 mg 5 mg | $63.00 $241.00 | 136 | |
U0126 selectively inhibits MEK1/2, which is part of the MAPK/ERK pathway. This pathway is involved in the proliferation and differentiation of T cells, including intraepithelial T cells 10. Inhibition of MEK by U0126 would result in the suppression of intraepithelial T cells 10 activation and function. | ||||||
SP600125 | 129-56-6 | sc-200635 sc-200635A | 10 mg 50 mg | $40.00 $150.00 | 257 | |
SP600125 inhibits JNK, which is involved in the regulation of T cell differentiation and function. Inhibition of JNK by SP600125 can lead to the suppression of intraepithelial T cells 10 activity by interfering with signaling pathways critical for their function. | ||||||
SB 203580 | 152121-47-6 | sc-3533 sc-3533A | 1 mg 5 mg | $88.00 $342.00 | 284 | |
SB203580 is an inhibitor of p38 MAPK, a kinase implicated in T cell activation and cytokine production. Inhibition of p38 MAPK by SB203580 would result in the functional inhibition of intraepithelial T cells 10 by impairing their activation and effector functions. | ||||||
PP 2 | 172889-27-9 | sc-202769 sc-202769A | 1 mg 5 mg | $92.00 $223.00 | 30 | |
PP2 is an inhibitor of Src family kinases which are associated with T cell receptor signaling. By inhibiting Src kinases, PP2 can disrupt the signaling required for intraepithelial T cells 10 activation and thereby inhibit their function. | ||||||
Dasatinib | 302962-49-8 | sc-358114 sc-358114A | 25 mg 1 g | $47.00 $145.00 | 51 | |
Dasatinib inhibits several tyrosine kinases including Src family kinases, c-KIT, and others. These kinases are involved in T cell activation and function. Inhibition of these kinases by Dasatinib can lead to functional inhibition of intraepithelial T cells 10 by disrupting critical signaling pathways. | ||||||
BIBF1120 | 656247-17-5 | sc-364433 sc-364433A | 5 mg 10 mg | $180.00 $315.00 | 2 | |
BIBF 1120 inhibits receptor tyrosine kinases involved in angiogenesis, which also play roles in the microenvironment of T cells, including intraepithelial T cells 10. By inhibiting these kinases, BIBF 1120 can disrupt the signaling that contributes to the function of intraepithelial T cells 10. | ||||||
PD 98059 | 167869-21-8 | sc-3532 sc-3532A | 1 mg 5 mg | $39.00 $90.00 | 212 | |
PD98059 is an inhibitor of MEK, which is part of the MAPK/ERK pathway involved in T cell activation. By specifically inhibiting MEK, PD98059 would disrupt the pathway and inhibit the activation and function of intraepithelial T cells 10. | ||||||