SIRP-α2 Inhibitors
SIRP-α2 inhibitors are a class of chemical compounds specifically designed to target and inhibit the activity of Signal Regulatory Protein Alpha 2 (SIRP-α2). SIRP-α2 is a transmembrane protein that belongs to the immunoglobulin superfamily and plays a significant role in regulating immune cell functions. It is primarily expressed on myeloid cells such as macrophages and dendritic cells. SIRP-α2 functions as a receptor involved in cell-cell communication, particularly by interacting with ligands like CD47. This interaction delivers inhibitory signals that modulate processes such as phagocytosis, cell adhesion, and migration. By inhibiting SIRP-α2, these compounds disrupt these signaling pathways, thereby affecting the regulatory mechanisms of the immune response.
In research settings, SIRP-α2 inhibitors are valuable tools for exploring the molecular mechanisms underlying immune regulation and intercellular communication. By blocking the activity of SIRP-α2, scientists can investigate how the inhibition affects downstream signaling pathways involved in immune cell activation and phagocytosis. This allows for the study of changes in cellular functions such as cytokine production, antigen presentation, and the clearance of apoptotic cells. Additionally, SIRP-α2 inhibitors provide insights into the interactions between SIRP-α2 and other immune receptors, contributing to a deeper understanding of the complex networks that govern immune homeostasis. Through these studies, the use of SIRP-α2 inhibitors enhances our knowledge of immunoregulatory mechanisms and the cellular processes that maintain the balance of the immune system.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Doxorubicin | 23214-92-8 | sc-280681 sc-280681A | 1 mg 5 mg | $173.00 $418.00 | 43 | |
Doxorubicin might intercalate with DNA within the SIRP-α2 gene promoter region, blocking transcription initiation and thereby downregulating SIRP-α2 production. | ||||||
Trichostatin A | 58880-19-6 | sc-3511 sc-3511A sc-3511B sc-3511C sc-3511D | 1 mg 5 mg 10 mg 25 mg 50 mg | $149.00 $470.00 $620.00 $1199.00 $2090.00 | 33 | |
Trichostatin A could de-repress chromatin by inhibiting histone deacetylase, leading to a tightened chromatin structure around the SIRP-α2 locus and reduced transcription. | ||||||
Imatinib | 152459-95-5 | sc-267106 sc-267106A sc-267106B | 10 mg 100 mg 1 g | $25.00 $117.00 $209.00 | 27 | |
Imatinib may block the activity of tyrosine kinases that phosphorylate transcription factors critical for SIRP-α2 gene transcription, resulting in decreased mRNA levels. | ||||||
Bortezomib | 179324-69-7 | sc-217785 sc-217785A | 2.5 mg 25 mg | $132.00 $1064.00 | 115 | |
Bortezomib could lead to the accumulation of misfolded proteins, triggering a cellular stress response that may include the downregulation of SIRP-α2 expression as a feedback mechanism. | ||||||
Actinomycin D | 50-76-0 | sc-200906 sc-200906A sc-200906B sc-200906C sc-200906D | 5 mg 25 mg 100 mg 1 g 10 g | $73.00 $238.00 $717.00 $2522.00 $21420.00 | 53 | |
This compound binds to the DNA at the transcription initiation complex, inhibiting the elongation phase of RNA synthesis and thus decreasing SIRP-α2 mRNA transcription. | ||||||
Rapamycin | 53123-88-9 | sc-3504 sc-3504A sc-3504B | 1 mg 5 mg 25 mg | $62.00 $155.00 $320.00 | 233 | |
By inhibiting mTOR, Rapamycin could suppress the translation of many mRNA transcripts, including those for SIRP-α2, leading to reduced protein synthesis. | ||||||
Chloramphenicol | 56-75-7 | sc-3594 | 25 g | $53.00 | 10 | |
Though primarily targeting bacterial ribosomes, a hypothetical eukaryotic analog of Chloramphenicol might inhibit ribosomal activity, diminishing the translation of SIRP-α2 mRNA. | ||||||
5-Azacytidine | 320-67-2 | sc-221003 | 500 mg | $280.00 | 4 | |
5-Azacytidine could induce demethylation of CpG islands in the promoter region of the SIRP-α2 gene, potentially leading to gene silencing and decreased expression. | ||||||
Mycophenolic acid | 24280-93-1 | sc-200110 sc-200110A | 100 mg 500 mg | $68.00 $261.00 | 8 | |
By inhibiting the de novo synthesis of guanosine nucleotides, Mycophenolic acid might reduce the availability of these nucleotides, resulting in a decrease in SIRP-α2 mRNA transcription. | ||||||
Flavopiridol | 146426-40-6 | sc-202157 sc-202157A | 5 mg 25 mg | $78.00 $254.00 | 41 | |
Flavopiridol inhibits cyclin-dependent kinases that are necessary for RNA polymerase II activation, potentially resulting in a halt in SIRP-α2 transcription. | ||||||