Sialyl Lewis a Activators

Sialyl Lewis a Activators are a unique class of chemical entities that serve to augment the functionality of Sialyl Lewis a, a carbohydrate marker displayed on certain white blood cells and some malignancies. These activators exert their influence in a two-fold manner: they stimulate the enzymes responsible for the construction of Sialyl Lewis a, and they supply the necessary raw materials needed for its formation.

The substrates such as Galactose, N-Acetylneuraminic Acid, N-Acetylgalactosamine, Fucose, and N-Acetylglucosamine serve as the core components of Sialyl Lewis a. Their availability is critical in fortifying the production of Sialyl Lewis a, as they provide the essential elements for its assembly. Another compound, 2-Deoxy-D-glucose, plays a supportive role by amplifying the supply of these precursor molecules, indirectly contributing to the amplification of Sialyl Lewis a production. Conversely, compounds like Fucoidan, Retinoic Acid, Ascorbic Acid, Epigallocatechin Gallate (EGCG), Dexamethasone, and Thiamine serve a different function. They act to stimulate the enzymes, notably FUT3 and FUT6, that are directly implicated in the synthesis pathway of Sialyl Lewis a. By boosting the activity of these enzymes, these compounds effectively facilitate the increased production and enhanced functionality of Sialyl Lewis a, contributing to the overall effectiveness and presence of this crucial carbohydrate marker.